Oral contraception can decrease the pituitary capacity to release gonadotrophins in response to synthetic LH-releasing-hormone

Robyn, Claude; Schöndorf, H; Jürgensen, O; Js, Dericks-Tan; Hd, Taubert

doi:10.1007/bf00672676

Cited by 16 publications

(2 citation statements)

References 25 publications

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“…It remains to be investigated whether more prolonged treatment with testosterone would not reduce the reactivity and/or the reserve capacity of gonado-trophin sécrétions as observed after long term administration of oestrogens in combined contraceptive pills [Robyn et al 1974;Perez-Lopcz cl al. 1975).…”

Section: Discussionmentioning

confidence: 99%

Effects of Testosterone on Gonadotrophin Responses to Synthetic Lh and FSH Releasing Hormone (Lrh) in Normal Men

Robyn

L’Hermite

Leclercq

et al. 1976

Acta Endocrinologica

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LRH tests were performed in 6 adult men with intravenous injections of 25 μg, before and one week after an intramuscular injection of 250 mg testosterone oenanthate (Testoviron Depot®). One week after intramuscular injection of Testoviron the tonic secretion of LH was completely suppressed, but the reactivity or the reserve capacity of LH secretion, as tested by LRH, remained unchanged. In contrast, the tonic secretion of FSH and the reactivity of FSH secretion to LRH were both partly suppressed. Three months after the Testoviron injection, the basal levels of LH were still significantly lower than the control values, but the basal levels of FSH were identical to the control values. These data indicate that, in man, the feedback action of testosterone on gonadotrophin secretion could be exerted, at least for LH, at the hypothalamic level rather than at the pituitary level. No significant effects of LRH were noted on the circulating levels of growth hormone and sugar. There was a distinct rise in serum prolactin, which was occasionally significant, within 30 min after LRH injection; this is considered to be without physiological significance.

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Section: Discussionmentioning

confidence: 99%

Effects of Testosterone on Gonadotrophin Responses to Synthetic Lh and FSH Releasing Hormone (Lrh) in Normal Men

Robyn

L’Hermite

Leclercq

et al. 1976

Acta Endocrinologica

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“…However, suppression of LH and FSH releases with 100 pg LHRH or more was recently reported by Robyn et al (1973aRobyn et al ( , 1974 and Lemarchand-Biraud et al (1974) in women taking oral contraceptives. In the two last studies, oral contraceptives were administered for more than 6 months whereas in the previous reports they were administered for 1 or 2 weeks (Kastin et al, 1969(Kastin et al, , 1972 or for 1-6 months (Thomas et al, 1972).…”

Section: Discussionmentioning

confidence: 79%

Gonadotrophin Hormone Releasing Tests in Women Receiving Hormonal Contraception

Pérez‐López

L’Hermite

Robyn

1975

Clinical Endocrinology

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Gonadotrophin secretion by the pituitary was tested by i.v. injections of synthetic LH and FSH releasing hormone (LHRH) in five normal women between day 21 and day 25 of the luteal phase of the cycle, in twelve women receiving contraception with i.m. injection of medroxyprogesterone acetate and in eight women taking combined oral contraceptives of different varieties. Treatment with oral contraceptives led to a decrease or even to complete suppression of the response and possibly the reserve capacity of both LH and FSH secretions. Treatment with medroxyprogesterone acetate for several years lowered basal serum LH and FSH as did oral contraceptives but had much less effect on the responses to LRH. In long-term steroid contraception, progestogens alone seem to exert much less deleterious effect on gonadotrophin function than when used in combination with an oestrogen.

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Potency of Contraceptive Progestins to Inhibit Luteinizing Hormone Secretion in Vitro

Kiesel

Rabe

Helm

et al. 1988

Female Contraception

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Oral contraception can decrease the pituitary capacity to release gonadotrophins in response to synthetic LH-releasing-hormone

Cited by 16 publications

References 25 publications

Effects of Testosterone on Gonadotrophin Responses to Synthetic Lh and FSH Releasing Hormone (Lrh) in Normal Men

Effects of Testosterone on Gonadotrophin Responses to Synthetic Lh and FSH Releasing Hormone (Lrh) in Normal Men

Gonadotrophin Hormone Releasing Tests in Women Receiving Hormonal Contraception

Potency of Contraceptive Progestins to Inhibit Luteinizing Hormone Secretion in Vitro

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