Oral Complications from Oropharyngeal Cancer Therapy

Sankar, Vidya; Xu, Yuanming

doi:10.3390/cancers15184548

Cited by 3 publications

(2 citation statements)

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“…However, an exception to this trend is observed in patients with head and neck tumors, where the risk of developing oral issues is also notable. Among patients undergoing chemotherapy, disturbances in the function of the gastrointestinal mucosa are a significant concern [ 7 ]. Mucositis, a transient adverse effect of chemotherapy, can affect the upper gastrointestinal tract, manifesting in symptoms ranging from dry mouth to the development of oral ulcers and discomfort during swallowing [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Oral health of chemotherapy patients before and after provision of oral hygiene instructions at a tertiary care hospital: pre-post design

Amin,

Khan,

Allana

et al. 2024

BMC Oral Health

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Objective Disturbances in the oral mucosa is a major concern among patients undergoing chemotherapy. One of the most significant barriers in the implementation of oral care is the lack of knowledge. The aim of the study was to assess gingival and periodontal health status of chemotherapy patients before and after the provision of oral hygiene instructions. Methods A single group, pre-post test was conducted to assess oral health status of patients at the daycare chemotherapy, Aga Khan University Hospital, Karachi, Pakistan. Oral hygiene instructions were given with study models and leaflets. Patients were followed for 6-weeks. Oral health was assessed by using Simplified-Oral Hygiene Index (OHI-S) and Community Periodontal Index (CPI). Differences in indices were analyzed in STATA version-15.0 using Generalized Estimating Equation (GEE) and Wilcoxon Signed-rank test. Results Out of 74, 53 (72%) patients completed study follow-up. Improvement in the OHI-S was found in 14 (26%) patients (p-value < 0.001). GEE showed that age [adjusted OR = 1.10; 95% CI: 1.03–1.11], current chemotherapy cycle [adjusted OR = 1.19; 95% CI: 0.98–1.46], highest education level [Adjusted OR = 1.37; 95% CI: 1.08–12.7] and cancer therapy [Adjusted OR = 0.12; 95% CI: 0.24–0.55] were significantly associated with the change in OHI-S. Wilcoxon signed-rank test showed positive changes in the CPI (p-value < 0.001). Conclusions Basic oral hygiene instructional intervention can be effective in improving the oral hygiene of chemotherapy patients. Nurses should also play a key role in providing psychological and nutritional support to patients.

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Section: Introductionmentioning

confidence: 99%

Oral health of chemotherapy patients before and after provision of oral hygiene instructions at a tertiary care hospital: pre-post design

Amin,

Khan,

Allana

et al. 2024

BMC Oral Health

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“…Treatment of malignant diseases can lead to inevitable lesions to the oral organs, including the mucous membrane, since the oral cavity is very sensitive to the toxic effects of chemotherapy and ionizing radiation [4].…”

Section: Introductionmentioning

confidence: 99%

Oral Tissue Lesions Manifestation in Cancer Patients Following Chemotherapy and Head and Neck Radiation Therapy

Mathevosyan,

Hakobyan

2024

J Oncology

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Background: As is known, cancer therapy includes a complex of therapeutic measures: chemotherapy, radiotherapy and radical. The purpose of this study was to review the literature on the main oral tissue complications arising from chemotherapy and radiation therapy in the head and neck region. Methods: In Google Scholar, Medline, Scopus, Web of Sciences, PubMed a systematic review was conducted. Search keywords terms included: Cancer patients, oral tissue lesions, head and neck, chemotherapy, radiation therapy. Conducted a preliminary search and reviewed 134 titles and abstracts in this literary review included 58. Cancer patients in the oral cavity exhibit a variety of oral tissue lesions during and shortly after radiation therapy to the head and neck. Results: Our search showed that cancer patients following chemotherapy and head and neck radiation therapy often experience oral manifestations. Among these lesions, increased susceptibility to dental caries, periodontal disease, oral mucositis, tissue fibrosis, salivary gland dysfunction, o pportunistic infections of the mucous membranes, and neurosensory disorders are often encountered. These manifestations represent a serious problem for patients and require special strategies from treating physicians to mitigate the harmful effects of radiation therapy on vital functions and improve the quality of life of these patients. Complications in the oral cavity, chemotherapy and head and neck radiation therapy creates many social problems and difficulties for cancer patients. Arguments for an interdisciplinary approach to the management of these patients are recommended in many studies. Conclusion: This review will help dental practitioners manage the risks of dental interventions and prevent potential complications in patients with cancer requiring dental care. Prevention, supportive care, and symptom management by health care providers are important for patients with oral problems related to cancer treatment and can help the patient cope with cancer and its complications.

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