Oral Complications and Management Strategies for Cancer Patients: Principles of Supportive Oncology in Dentistry

Parra-Rojas, Susell; Velázquez-Cayón, Rocío Trinidad; Borges-Gil, Acorán; Mejías-Torrus, Juan Luis; Cassol-Spanemberg, Juliana

doi:10.1007/s11912-024-01518-5

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…Antineoplastic treatment can compromise the patient's quality of life and nutritional status, in addition to being a limiting factor in the progression of chemotherapy and radiotherapy [1,2,3,4,5]. Oral mucositis (OM) and oropharyngeal mucositis (OPM) are common acute complications in patients undergoing antineoplastic therapy characterized by painful symptoms [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Mouthwashes used in patients with oral and oropharyngeal mucositis: A systematic review

Costa,

Dias,

Rodrigues

et al. 2024

Preprint

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Purpose The aim of this study was to conduct a systematic review of randomized clinical trials in order to assess the efficacy of the following mouthwashes recommended for the prevention and treatment of OM and OPM in patients undergoing cancer treatment: chlorhexidine, allopurinol, benzydamine, and propolis. Methods The following research question was formulated based on the PICOS strategy: “Are chlorhexidine, allopurinol, benzydamine and propolis mouthwashes effective in preventing and treating OM and OPM in patients undergoing cancer treatment?” Searches were performed in PubMed, Embase, Scopus, and Web of Science, without publication year or language restrictions. Randomized clinical trials comparing the use of chlorhexidine, allopurinol, benzydamine and propolis with a control group not submitted to any intervention were included. The retrieved articles were analyzed and selected by two reviewers and disagreements were resolved by consultation with a third reviewer. After data extraction, two evaluators independently analyzed the methodological quality of the studies using the Cochrane tool. Results After evaluation of the works, 13 of 1183 articles were selected. mouthwashes containing propolis and benzydamine mouthwashes were promising and effective while chlorhexidine or allopurinol did not provide satisfactory results. Conclusion Mouthwashes could be an alternative for treatment or preventing oral mucositis in cancer patients Services could consider the possibility of incorporating these medications since, in most cases, they are low cost and donot require specialized staff in their use.

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Section: Introductionmentioning

confidence: 99%

Mouthwashes used in patients with oral and oropharyngeal mucositis: A systematic review

Costa,

Dias,

Rodrigues

et al. 2024

Preprint

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Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid

Guo,

Wan,

Shen

et al. 2024

J Transl Med

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Background The cancer microbiota was considered the main risk factor for cancer progression. We had proved that Fusobacterium periodonticum (F.p) was higher abundance in Esophageal cancer(EC)tissues. Bioinformation analysis found that BCT was a key virulence protein of F.p. However, little is known about the role and mechanism of BCT in EC. This study aimed to recognize the key virulence protein of F.p and explore the mechanism of BCT in promoting EC. Methods We constructed a eukaryotic expression vector and purified the recombinant protein BCT. CCK8 used to analyzed the activity of EC after treated by different concentration of BCT. UPLC-MS/MS and ELISA used to detect the metabonomics and metabolites. The ability of migration and invasion was completed by transwell assay. RT-QPCR, WB used to analyze the expression of relevant genes. Results Our data showed that BCT was higher expression in EC tumor tissues (p < 0.05) and BCT in 20 µg/mL promoted the survival, invasion and migration of EC cells (EC109) (p < 0.05). Meanwhile, UPLC-MS/MS results suggested that BCT resulted in an augmentation of hypotaurine metabolism, arachidonic acid metabolism, glycolysis/gluconeogenesis, tryptophan metabolism, citrate cycle activity in EC109. The metabolic changes resulted in decreasing in glucose and pyruvate levels but increase in lactate dehydrogenase (LDH) activity and lactic acid (LA) as well as the expression of glucose transporter 1, Hexokinase 2, LDH which regulated the glycolysis were all changed (p < 0.05). The BCT treatment upregulated the expression of TLR4, Akt, HIF-1α (p < 0.05) which regulated the production of LA. Furthermore, LA stimulation promoted the expression of GPR81, Wnt, and β-catenin (p < 0.05), thereby inducing EMT and metastasis in EC109 cells. Conclusion Altogether, these findings identified that impact of BCT in regulation of glycolysis in EC109 and its involves the TLR4/Akt/HIF-1α pathway. Meanwhile, glycolysis increasing the release of LA and promote the EMT of EC109 by GPR81/Wnt/β-catenin signaling pathway. In summary, our findings underscore the potential of targeting BCT as an innovative strategy to mitigate the development of EC.

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Oral Complications and Management Strategies for Cancer Patients: Principles of Supportive Oncology in Dentistry

Cited by 2 publications

References 47 publications

Mouthwashes used in patients with oral and oropharyngeal mucositis: A systematic review

Mouthwashes used in patients with oral and oropharyngeal mucositis: A systematic review

Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid

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