Oral Colchicine for the Treatment of Experimental Traction Retinal Detachment

Comparison of Colchicine, Dapsone, Triamcinolone, and Diphenhydramine Therapy for the Treatment of Brown Recluse Spider Envenomation

“…This dose was chosen because there is little published data regarding the lethal dose of colchicine in rabbits, and this dose was well tolerated in an unrelated study. 5 The study rabbits receiving triamcinolone received a single 4-mL injection of 10-mg/mL triamcinolone infiltrated subcutaneously in the area of envenomation, 2 hours after envenomation. The study rabbits receiving diphenhydramine received a 10-mg/kg subcutaneous injection twice daily for 7 days.…”

Stage specificity of novel growth factor expression during development of proliferative vitreoretinopathy

“…These data suggest that a prophylactic, post-surgical intravitreal injection of a cocktail of antibodies targeted against CTGF, HGF, and PDGF may help reduce the recurrence of PVR. A treatment strategy that targets these growth factors, or their receptors, may be more beneficial in inhibiting PVR development, than nonspecific antiproliferative agents, such as heparin, 36 daunorubicin, 37 5-fluorouracil (5-FU), 38 colchicine, 39 taxol, 40 radiation 41 or a ribozyme technology targeted to proliferating cell nuclear antigen (PCNA). 42 …”

Simple retinal detachments: identifying the at-risk case

“…49 Laboratory and clinical studies suggest that pharmacological adjuvant therapy can modify the proliferative disease process and improve the success of surgery. There are a number of studies showing a potential benefit of a variety of pharmacological interventions including: retinoic acid, 7-17,50,51 dexamethasone, [11][12][13]52,53 colchicine, 14,15,54 taxol 16,17,55 and daunorubicin. 18,19,56 However, none of these regimens are in routine clinical use.…”