Oral Cobalamin Therapy for the Patient with Biermer’s Disease

Andrès, Emmanuel

doi:10.4172/2155-9864.1000e117

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…The aforementioned results were also observed in a population of patients presenting with Biermer's disease (Table 3) [33]. In this setting, the CARE B12 group studied in an open study 10 patients with welldocumented vitamin B12 deficiency related to pernicious anemia who daily received 1,000 µg (1 mg) of oral crystalline cyanocobalamin for at least 3 months [32].…”

Section: Study Characteristics (Number Of Patients) Therapeutic Modalities Resultsmentioning

confidence: 79%

State of art of oral vitamin B12 (cobalamin) treatment in Biermer's disease (pernicious anemia)

Andrès¹,

Zulfiqar²,

Vogel³

et al. 2018

Trends Med

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In the setting of vitamin B12 (cobalamin) deficiency, new routes (oral and nasal) of vitamin B12 replacement have being developed and studied. In Biermer's disease, two prospective controlled randomized studies, a recent systematic review by the Cochrane group and four prospective studies were found and provide evidence that oral vitamin B12 treatment may adequately treat cobalamin deficiency. The efficacy was documented with a marked improvement in serum vitamin B12 levels or normalization of this latter. The clinical efficacy was also established with an improvement or a normalization of hematological parameters. The safety was documented in the majority of the studies. In this setting, oral replacement will be of interest for clinicians to avoid painful and administration difficulties, and cost of monthly injections. To date, effect of oral vitamin B12 treatment has not yet been adequately documented in patients presenting with severe neurological manifestations.

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Section: Study Characteristics (Number Of Patients) Therapeutic Modalities Resultsmentioning

confidence: 79%

State of art of oral vitamin B12 (cobalamin) treatment in Biermer's disease (pernicious anemia)

Andrès¹,

Zulfiqar²,

Vogel³

et al. 2018

Trends Med

Self Cite

View full text Add to dashboard Cite

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State of the art review: oral and nasal vitamin B12 therapy in the elderly

Andrès

Zulfiqar

Vogel

2019

QJM: An International Journal of Medicine

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Summary The objective of this narrative review was to provide an update on oral and nasal vitamin B12 (cobalamin) therapy in elderly patients. Relevant articles were identified by ‘PubMed’ and ‘Scholar Google’ search from January 2010 to July 2018 and through hand search of relevant reference articles. Additional studies were obtained from references of identified studies, the ‘Cochrane Library’ and the ‘ISI Web of Knowledge’. Data retrieved from international meetings were also used, as was information retrieved from commercial sites on the web and data from ‘CARE B12’ research group. For oral vitamin B12 therapy, four prospective randomized controlled trials, eight prospective studies, one systematic and four reviews fulfilled our inclusion criteria. The studies included mainly or exclusively elderly patients (≥65-year-olds). In all of the studies, the mean age of the patients was at least 70 years except for two. The present review documents that oral vitamin B12 replacement at 1000 μg daily proved adequate to cure vitamin B12 deficiency, with a good safety profile. The efficacy was particularly marked when considering the noticeable improvement in serum vitamin B12 levels and haematological parameters, such as haemoglobin level, mean erythrocyte cell volume and reticulocyte count. The effect of oral cobalamin treatment in patients presenting with severe neurological manifestations has not yet been adequately documented. For nasal vitamin B12, only a few preliminary studies were available. We conclude that oral vitamin B12 is an effective alternative to intramuscular vitamin B12 injections in elderly patients. Oral vitamin B12 treatment avoids the discomfort, inconvenience and cost of monthly injections.

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Oral Cobalamin Therapy for the Patient with Biermer’s Disease

Cited by 2 publications

References 6 publications

State of art of oral vitamin B12 (cobalamin) treatment in Biermer's disease (pernicious anemia)

State of art of oral vitamin B12 (cobalamin) treatment in Biermer's disease (pernicious anemia)

State of the art review: oral and nasal vitamin B12 therapy in the elderly

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