1998
DOI: 10.1016/s0952-8180(98)00073-7
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Oral clonidine premedication does not prolong analgesia after herniorrhaphy under subarachnoid anesthesia

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Cited by 13 publications
(11 citation statements)
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“…Oral clonidine has maximal effect intraoperatively when it is given 60 min before spinal injection. The analgesic effect decreased dramatically when it was administered 90–180 min prior to spinal anaesthesia (6, 17). To get the best effect, we therefore administered clonidine at a dose of 150 µg 60 min before the spinal injection.…”
Section: Discussionmentioning
confidence: 99%
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“…Oral clonidine has maximal effect intraoperatively when it is given 60 min before spinal injection. The analgesic effect decreased dramatically when it was administered 90–180 min prior to spinal anaesthesia (6, 17). To get the best effect, we therefore administered clonidine at a dose of 150 µg 60 min before the spinal injection.…”
Section: Discussionmentioning
confidence: 99%
“…Reports in the literature are contradictory concerning the analgesic effect of oral clonidine in non‐orthopaedic surgery. Some authors failed to detect improved postoperative analgesia or reduced postoperative morphine consumption in patients after non‐orthopaedic surgery (6, 7, 29). In other investigations (30–32) it has been shown that oral clonidine not only has a good analgesic effect, but it also has a synergistic effect with opioids.…”
Section: Discussionmentioning
confidence: 99%
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“…Several authors demonstrated the low pre spinal blood pressure following clonidine premedication and incidence of hypotension following spinal anaesthesia. 11 Few studies showed incidences of bradycardia at a dose of (5g/kg) 12 and studies have shown bradycardia at 200/g. 13 We did not see any exaggerated changes in heart rate or blood pressure following premedication like severe hypotension or severe bradycardia.…”
Section: Discussionmentioning
confidence: 99%
“…Como esperado, os pacientes que participaram deste estudo não apresentaram queda da frequência respiratória após o uso de clonidina ou sufentanil, a qual só tem sido relatada após administração de doses elevadas desses dois fármacos. Ezri et al (1998), em sua pesquisa, detectaram a ocorrência de bradipneia após aplicação de clonidina na dose de 5mcg/kg, o que corresponde a dez vezes a dose administrada neste estudo. CARVALHO et al, 1999), estando asssociados a desconforto para o paciente e a complicações, como desidratação, elevação da pressão intracraniana e intraocular, pneumonite aspirativa, distúrbios eletrolíticos e até mesmo rotura esofágica (SCHMIDT; BAGATINI, 1997;KU;ONG, 2003).…”
Section: Frequência Respiratóriaunclassified