Oral Chinese Herbal Medicine for Improvement of Quality of Life in Patients with Stable Chronic Obstructive Pulmonary Disease: A Systematic Review

An, Xuedong; Zhang, Anthony Lin; May, Brian H.; Lin, Lin; Xu, Yinji; Xue, Charlie Changli

doi:10.1089/acm.2011.0389

Cited by 30 publications

(29 citation statements)

References 19 publications

(23 reference statements)

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“…Using Chinese medicines or integrated Chinese and Western medicines to treat stable COPD has significant efficacy [6], improving pulmonary function and increasing diaphragm muscular tension [7]. A large amount of high-quality and high-level evidence has shown that its efficacy in improving symptoms, reducing exacerbations, and improving exercise capacity and quality of life is better than treatment with Western medicines alone [8–10]. …”

Section: Introductionmentioning

confidence: 99%

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Wang

Yang

et al. 2016

BMC Complement Altern Med

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BackgroundChronic obstructive pulmonary disease (COPD) is a common and frequently occurring respiratory disease. At present, western medicine treatment of COPD mainly focuses on symptomatic treatment. Using Chinese medicines or integrated Chinese and Western medicines to treat stable COPD has significant efficacy. In this study, we aimed to observe the effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats and explore its possible mechanism.MethodsSD rats were randomized into blank group, COPD model group and Radix Stemonae group, 10 cases in each group. Rats were fed for 112 days. Before the rats were sacrificed, lung function of the animals was tested. The right lower lung was fixed for morphologic observation. The inflammatory mediators in serum were determined using enzyme-linked immuno sorbent assay.ResultsBody weight of animals in the model group was significantly decreased compared with blank group (P < 0.05). After gavage therapy with Radix Stemonae, body weight was significantly increased (P < 0.05). Compared with the blank group, pulmonary functions of rats in the model group were significantly abnormal (P < 0.05), while in Radix Stemonae group, these indicators turned much better than model group (P < 0.05). As for pathological changes in lungs, airway inflammation in the model group was aggravated. In the Radix Stemonae group, inflammation and emphysema were much milder. The concentrations of TNF-α, IL-8 and LTB4 in both model group and Radix Stemonae group were increased significantly (P < 0.05). But the levels in Radix Stemonae group were decreased significantly than model group (P < 0.05).ConclusionRadix Stemonae concentrated decoction may mitigate and improve airway rebuilding in the lungs of COPD rats by inhibiting the release of inflammatory mediators.

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Section: Introductionmentioning

confidence: 99%

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Wang

Yang

et al. 2016

BMC Complement Altern Med

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“…Among these herbs include those that have been described to possess anti-infective properties [9-11]. Traditionally, most of these herbal-based medications are dispensed in aqueous forms, and be administered orally [12]. Given the availability of huge number of traditionally used medicinal plants, it is likely that at least a few of these would exhibit antiviral activities at concentrations suitable for direct consumption [13].…”

Section: Introductionmentioning

confidence: 99%

Extract of Scutellaria baicalensis inhibits dengue virus replication

Zandi

Lim²,

Rahim

et al. 2013

BMC Complement Altern Med

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BackgroundScutellaria baicalensis (S. baicalensis) is one of the traditional Chinese medicinal herbs that have been shown to possess many health benefits. In the present study, we evaluated the in vitro antiviral activity of aqueous extract of the roots of S. baicalensis against all the four dengue virus (DENV) serotypes.MethodsAqueous extract of S. baicalensis was prepared by microwave energy steam evaporation method (MEGHE™), and the anti-dengue virus replication activity was evaluated using the foci forming unit reduction assay (FFURA) in Vero cells. Quantitative real-time polymerase chain reaction (qRT-PCR) assay was used to determine the actual dengue virus RNA copy number. The presence of baicalein, a flavonoid known to inhibit dengue virus replication was determined by mass spectrometry.ResultsThe IC50 values for the S. baicalensis extract on Vero cells following DENV adsorption ranged from 86.59 to 95.19 μg/mL for the different DENV serotypes. The IC50 values decreased to 56.02 to 77.41 μg/mL when cells were treated with the extract at the time of virus adsorption for the different DENV serotypes. The extract showed potent direct virucidal activity against extracellular infectious virus particles with IC50 that ranged from 74.33 to 95.83 μg/mL for all DENV serotypes. Weak prophylactic effects with IC50 values that ranged from 269.9 to 369.8 μg/mL were noticed when the cells were pre-treated 2 hours prior to virus inoculation. The concentration of baicalein in the S. baicalensis extract was ~1% (1.03 μg/gm dried extract).ConclusionsOur study demonstrates the in vitro anti-dengue virus replication property of S. baicalensis against all the four DENV serotypes investigated. The extract reduced DENV infectivity and replication in Vero cells. The extract was rich in baicalein, and could be considered for potential development of anti-DENV therapeutics.

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“…(31) Low concentration coix seed oil can excite in vitro frog hearts, while high concentrations regulate the central nervous system and improve anxiety and depression. (32) In conclusion, RA treatment should not just focus on joint lesions. The psychological health and quality of life of patients should also be considered.…”

Section: Discussionmentioning

confidence: 99%

Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial

Wan

Liu

Huang

et al. 2016

Chin. J. Integr. Med.

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Oral Chinese Herbal Medicine for Improvement of Quality of Life in Patients with Stable Chronic Obstructive Pulmonary Disease: A Systematic Review

Abstract: While the results of CHM on HRQoL for stable COPD sufferers were promising, they need to be interpreted with caution due to methodological problems, which should be addressed in future trials.

Cited by 30 publications

References 19 publications

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Extract of Scutellaria baicalensis inhibits dengue virus replication

Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial

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