Oral changes in patients with psoriasis

Sobecka-Frankiewicz, Magdalena; Rudnicka, Joanna; Iwanicka-Grzegorek, Ewa; Mielczarek, Agnieszka

doi:10.1111/ijd.16350

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Additionally, the vermilion of the lips may be affected, leading to recurring exfoliation and dryness. Occasionally, however rarely, the alterations manifest in the gingival region, presenting as exfoliation gingivitis with corresponding clinical features [ 16 , 18 , 20 , 21 ]. Lesions located in the lingual portion of the oral cavity are frequently observed in the form of geographic tongue or fissured tongue [ 20 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Occasionally, however rarely, the alterations manifest in the gingival region, presenting as exfoliation gingivitis with corresponding clinical features [ 16 , 18 , 20 , 21 ]. Lesions located in the lingual portion of the oral cavity are frequently observed in the form of geographic tongue or fissured tongue [ 20 , 22 ]. This report presents a rare case of ePsA with concurrent lingual psoriatic lesions, resembling geographic tongue (GT), without any pre-existing cutaneous lesions.…”

Section: Introductionmentioning

confidence: 99%

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An Unusual Case of Psoriatic Arthritis With Secondary Lingual Lesions, Resembling Geographic Tongue

Zisis,

Theodoridou,

Anagnostou

et al. 2024

Cureus

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Psoriatic arthritis (PsA) is a chronic inflammatory condition that impacts a significant proportion of individuals diagnosed with psoriasis. This report presents a rare case of a patient diagnosed with PsA who never had active psoriatic skin lesions but only a family history of psoriasis, with secondary lingual lesions, resembling geographic tongue (GT). A male patient, 24 years old, was referred with two painless erythematous areas resembling (without whitish borders, as in GT) rounded atrophic lesions on the dorsal surface of the tongue, resistant to any kind of antimicrobial/antifungal treatment for more than six months. The patient was diagnosed with PsA two years ago fulfilling the CASPAR (ClASsification for Psoriatic ARthritis) criteria. The patient never had active psoriatic skin lesions, but his father had psoriasis. The biopsy of lingual lesions showed moderate hyperkeratosis, spongiosis, and diffuse inflammatory infiltration of lymphocytes and neutrophils in the lamina propria as well as in the stratified squamous epithelium forming Munro’s microabscesses at the superficial layers. The manifestation of the atypical psoriasiform, GT-like lingual lesions was considered as part of psoriasis manifestations and the patient was advised to follow regular checkups so that any major exacerbation of the systematic symptoms could be preemptively avoided. Not only GT but also atypical lingual GT-like reddish oral lesions may be considered as transient forms of psoriasis supporting an early diagnosis and monitoring of psoriasis/PsA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Unusual Case of Psoriatic Arthritis With Secondary Lingual Lesions, Resembling Geographic Tongue

Zisis,

Theodoridou,

Anagnostou

et al. 2024

Cureus

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Association of psoriasis with geographic and fissured tongue in the Han population in southwestern China

Hu,

Li,

Yan

et al. 2024

Anais Brasileiros de Dermatologia

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Exploration of the underlying comorbidity mechanism in psoriasis and periodontitis: a bioinformatics analysis

et al. 2023

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Background Increasing evidence indicates that psoriasis (PSO) and periodontitis (PD) are likely to occur together, however, the underlying mechanism remains unclear. Materials and methods The expression profiles of PSO (lesion vs non-lesion, GSE30999, GSE14905) and PD (affected vs unaffected gingival tissue, GSE16134, GSE10334) were downloaded from the GEO database. First, we investigated the common differentially expressed genes (DEGs) of PSO and PD. Then, GO and KEGG enrichment analysis, protein interaction network (PPI) construction, and hub gene identification analysis were carried out. Finally, GO and KEGG enrichment analysis, miRNA interaction analysis, and transcription factors (TFs) interaction analysis for hub genes were performed. Results Eighteen DEGs were identified for further analysis, including 15 up-regulated genes and 3 down-regulated genes. 9 hub genes were then identified via Cytohubba, including IL1B, CXCL1, CXCL8, MMP12, CCL18, SELL, CXCL13, FCGR3B, and SELE. Their functions are mainly enriched in two aspects: neutrophil chemotaxis and migration, chemokine activation and interaction. The enriched signaling pathways includes three categories: host defense, inflammation-related signaling pathways, and disease-related pathways. 9 common miRNAs based on experimental evidence and 10 common TFs were further identified in both PSO and PD. Conclusion Our study revealed possible comorbidity mechanisms in PSO and PD from the perspective of bioinformatics tentatively. The data can present new insight for joint prevention and treatment of in PSO and PD, as well as provide data support for further prospective studies.

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Oral changes in patients with psoriasis

Cited by 3 publications

References 38 publications

An Unusual Case of Psoriatic Arthritis With Secondary Lingual Lesions, Resembling Geographic Tongue

An Unusual Case of Psoriatic Arthritis With Secondary Lingual Lesions, Resembling Geographic Tongue

Association of psoriasis with geographic and fissured tongue in the Han population in southwestern China

Exploration of the underlying comorbidity mechanism in psoriasis and periodontitis: a bioinformatics analysis

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