Oral Cavity Cancer

Ettinger, Kyle S.; Ganry, Laurent; Fernandes, Rui

doi:10.1016/j.coms.2018.08.002

Cited by 112 publications

(92 citation statements)

References 60 publications

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“…The oral cavity, including the lip, is the sixth most common cancer in the world 1 . Oral squamous cell carcinoma (OSCC) accounts for more than 90% of all oral cancer 2 .…”

Section: Introductionmentioning

confidence: 99%

Perineural invasion in oral squamous cell carcinoma: Incidence, prognostic impact and molecular insight

Alkhadar

Macluskey

White

et al. 2020

J Oral Pathology Medicine

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Background The objective of this study was to characterise the incidence and prognostic correlation of perineural invasion (PNI) in oral squamous cell carcinoma and determine whether nerve growth factor and its receptor tyrosine Kinase A expression could be used as biological markers for PNI. Methods A retrospective review of pathology reports of 430 patients with oral squamous cell carcinoma who were treated from 1992 to 2014 in Tayside, Scotland, was carried out. The expression of nerve growth factor and tyrosine kinase A was assessed with immunohistochemistry in 132 tissue sections of oral squamous cell carcinoma. Results Perineural invasion was identified in 17.4% of oral squamous cell carcinomas. High expression of nerve growth factor and tyrosine kinase A was seen in 84% and 92% of oral squamous cell carcinoma, respectively. Tumours with PNI expressed nerve growth factor and tyrosine kinase A with a greater frequency than tumours without PNI. PNI and high expression of nerve growth factor were significantly associated with pain. PNI was significantly associated with stage IV tumours and poor disease‐specific survival. Conclusions A higher level of expression of nerve growth factor and tyrosine kinase A may predict PNI and therefore may be considered as biological markers for PNI in oral squamous cell carcinoma. PNI and nerve growth factor overexpression may contribute to the pain generation in oral cancer patients. PNI and nerve growth factor expression can predict the aggressiveness and prognosis of oral squamous cell carcinoma patients.

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“…The oral cavity, including the lip, is the sixth most common cancer in the world 1 . Oral squamous cell carcinoma (OSCC) accounts for more than 90% of all oral cancer 2 .…”

Section: Introductionmentioning

confidence: 99%

Perineural invasion in oral squamous cell carcinoma: Incidence, prognostic impact and molecular insight

Alkhadar

Macluskey

White

et al. 2020

J Oral Pathology Medicine

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“…Tobacco and alcohol are two major risk factors for OSCC [3]. Currently, surgery is the primary therapeutic strategy for OSCC, followed by radiotherapy and chemotherapy [4]. Treatments have significantly improved in recent years, but the prognosis of OSCC cases is still unsatisfactory, especially among those in advanced stages, showing a five-year survival rate of less than 50% [5].…”

Section: Introductionmentioning

confidence: 99%

MiR-638 suppresses the progression of oral squamous cell carcinoma through wnt/β-catenin pathway by targeting phospholipase D1

Tang

Han-Ying

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…If the tumor is discovered in the early stages and treated properly, the survival time is favorable; however, in advanced stages, the survival does not exceed two years, because the oral malignancies are extremely aggressive. The global mortality rate due to the oral cancer is estimated at about 3%-10% [10].It is noteworthy that a significant number of new chemotherapeutics used in cancer therapy were obtained from natural sources [11].There are still many potential plants sources of antitumor compounds, which need to be investigated, including the lichens [12]; they have a special dual structure, as a result of the symbiosis between a fungus and an algae/cyanobacteria [13]. The specific conditions in which they live determines the synthesis of numerous secondary metabolites, including most of these compounds with phenolic structure [14], which provide the lichens with optimal protection against disruptive, physical, and biological factors [15].…”

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confidence: 99%

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confidence: 99%

Evaluation of the Cytotoxic Activity of the Usnea barbata (L.) F. H. Wigg Dry Extract

et al. 2020

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The secondary metabolites of lichens have proven to be promising sources of anticancer drugs; one of the most important of these is usnic acid, which is a phenolic compound with dibenzofuran structure that is responsible for the numerous biological actions of lichens of genus Usnea. As a result, in this study, we related to this phenolic secondary metabolite. The aim of the present study is the evaluation of the cytotoxic activity of Usnea barbata (L.) F. H. Wigg dry acetone extract (UBE). In advance, the usnic acid content was determined in various extracts of Usnea barbata (L.) F. H. Wigg: the liquid extracts were found in water, ethanol, acetone, and the dry acetone extract; the highest usnic acid quantity was found in the dry acetone extract. First, the cytotoxic action of UBE was assessed using Brine Shrimp Lethality (BSL) test; a significant lethal effect was obtained after 24 h of treatment at high used concentrations of UBE, and it was quantified by the high mortality rate of the Artemia salina (L.) larvae. Secondly, in vitro cytotoxicity of UBE was evaluated on human tongue squamous cells carcinoma, using CAL 27 (ATCC ® CRL-2095™) cell line. The most intense cytotoxic effect of UBE on CAL 27 cells was registered after 24 h; this response is directly proportional with the tested UBE concentrations. The obtained results have been reported regarding usnic acid content of UBE, and the data show that CAL 27 cells death was induced by apoptosis and high oxidative stress.Molecules 2020, 25, 1865 2 of 17 therapeutic tools for the total destruction of cancer cells with limited effects on normal cells [1]. It is known that carcinogenesis is a complex process, involving cellular and molecular alterations, mediated by endogenous and/or exogenous factors: oxidative DNA damage, chromosomal abnormalities, and oncogene activation are responsible for the development of cancer and may be induced by prolonged oxidative stress [2]. Thus, in cancer pathology, the reactive oxygen species (ROS) have dual role, confirmed by many studies: first, ROS are cytotoxic, having an important contribution in the etiology and progression of cancer [3]. At the same time, many antitumor agents can destroy the cancer cells through intense oxidative stress, generating ROS production in high quantities [4]. Increasing ROS levels through redox modulation could in the future be an effective strategy for the selective destruction of cancer cells (not normal cells) [5]; this method is called "oxidative therapy" [6], and it was developed by inducing cytotoxic oxidation as a stress factor in cancer cells in the treatment of cancer [7].One of the most invasive malignancies is the oral squamous cell carcinoma (OSCC), which is the most common cancer of oral cavity; it can affect any part of the oral cavity including lips, tongue, gums, buccal epithelium, and salivary glands [8]. Despite that, the oral cavity is easily accessible for the direct visual examination, and the mortality from oral cancer remains still high because in the early stages, the pat...

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Oral Cavity Cancer

Cited by 112 publications

References 60 publications

Perineural invasion in oral squamous cell carcinoma: Incidence, prognostic impact and molecular insight

Perineural invasion in oral squamous cell carcinoma: Incidence, prognostic impact and molecular insight

MiR-638 suppresses the progression of oral squamous cell carcinoma through wnt/β-catenin pathway by targeting phospholipase D1

Evaluation of the Cytotoxic Activity of the Usnea barbata (L.) F. H. Wigg Dry Extract

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