Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature

Majchrzak, Ewa; Szybiak, Bartosz; Wegner, Anna; Pieńkowski, Piotr; Pazdrowski, Jakub; Łuczewski, Łukasz; Sówka, Marcin; Golusiński, Paweł; Malicki, Julian; Golusiński, Wojciech

doi:10.2478/raon-2013-0057

Cited by 141 publications

(135 citation statements)

References 74 publications

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“…14 However, Majchrzak et al 15 suggested that there will be an increase in OSCC incidence in young adults in the coming years. The development of this malignancy was observed mainly in females, and can be explained by the recent involvement of women in risky health practices.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HPV and EBV infection and their relationship with the p53 and PCNA expression in oral carcinoma patients.

Veitía¹,

Liuzzi

Ávila

et al. 2017

J Oral Res

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Introduction: Infection caused by potentially oncogenic viruses, such as HPV and EBV, favors the role of certain oncoproteins that can induce dysplasias and malignant lesions. Objective: To evaluate the prevalence of HPV and EBV and their relation with the expression of p53 and PCNA in patients with oral carcinoma. Methodology: Twenty-seven oral squamous cell carcinomas (OSCC) were evaluated; DNA extraction was conducted using the QIAamp DNA mini kit; viral detection was obtained using the IN-NO-LiPA kit for HPV, and nested PCR was used for EBV. The evaluation of molecular markers was performed through immunohistochemical staining. Results: The mean age of the patients was 60.55±13.94 years, and 52% of these were female. Of the patients, 59% were tobacco users and 63% were alcohol consumers. HPV was detected in 70% of the patients with the predominance of genotype 16 (60%). As for EBV infection, it was observed in 59% of cases. p53 and PCNA immunopositivity corresponded to 44% and 59%, respectively. The tongue was the anatomical location with highest positivity for both viruses as well as for the expression of molecular markers. The 48% of the cases presented infection by both viruses. Conclusion: HPV and EBV infection together with the expression of p53 and PCNA were more frequently observed in advanced stages of the disease, suggesting a more relevant role in the progression than in tumor genesis.

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Section: Discussionmentioning

confidence: 99%

Prevalence of HPV and EBV infection and their relationship with the p53 and PCNA expression in oral carcinoma patients.

Veitía¹,

Liuzzi

Ávila

et al. 2017

J Oral Res

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“…Diagnosis of metachronous and/or synchronous MN was defined according to the international association of cancer registry rules [32]. EO of cancer was defined for each primary tumor as follows: for NSCLC ≤60 years [33], for kidney cancer ≤46 years [34], for urothelial cancer ≤40 years [35][36][37], for melanoma ≤39 years [38,39], for colorectal cancer <50 years [40] and <45 years for head and neck carcinomas [41]. renal cell carcinoma 41 patients (19.4%), melanoma 51 patients (24.2%), NSCLC 104 patients (49.3%), urothelial cancer 10 patients (4.7%), colorectal cancer three patients (1.4%) and head and neck carcinomas two patients (1%).…”

Section: Definition Of Family History Of Cancer Multiple Neoplasms Andmentioning

confidence: 99%

Family History of Cancer as Surrogate Predictor for Immunotherapy with Anti-Pd1/Pd-L1 Agents: Preliminary Report of the Fami-L1 Study

et al. 2018

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Aim: Tumors related to hereditary susceptibility seem to have an immunosensitive phenotype. Materials & methods : We conducted a multicenter retrospective study, to investigate if family history of cancer, multiple neoplasms and early onset of cancer could be related to clinical outcomes of anti-PD-1/PD-L1 therapy. Activity and efficacy data of 211 advanced cancer patients (kidney, non-small-cell lung cancer, melanoma, urothelium, colorectal and HeN), treated at seven Italian centers with anti-PD-1/PD-L1 agents, were analyzed. Results: In this preliminary report at multivariate analyses, positive family history of cancer showed a statistically significant relationship with a better objective response rate (p = 0.0024), disease control rate (p = 0.0161), median time to treatment failure (p = 0.0203) and median overall survival (p = 0.0221). Diagnosis of multiple neoplasms significantly correlates only to a better disease control rate, while interestingly non-early onset of cancer and sex (in favor of female patients) showed significant correlation with a better median overall survival (p = 0.0268 and p = 0.0272, respectively). Conclusion: This pilot study seems to individuate easily available patient's features as possible predictive surrogates of clinical benefit for anti-PD-1/PD-L1 treatments. These preliminary results need to be confirmed with a greater sample size, in prospective trials with immunotherapy.

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“…In today's time there are 4% to 13% of the cases of oral squamous cell carcinoma that affects subjects younger than 45 years of age. [4][5][6][7][8][9][10] The most frequently affected site is tongue and it is seen generally amongst alcohol and tobacco users. 4,5 Squamous cell carcinoma of lower lip is generally seen amongst subjects with exposure to sunlight.…”

Section: Introductionmentioning

confidence: 99%

Clinical findings and risk factors associated with oral cancer: a prospective study

Gupta¹,

Singh²,

Bedi³

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Oral cancer is associated with high morbidity and mortality and therefore it represents a grave health problem worldwide. However there is scarcity of the studies in the literature regarding the prognostic factors amongst the subjects. The aim of the present study is to determine the various risk factors and the most commonly affected sites by the oral squamous cell carcinoma amongst subjects of different age groups. Methods: The present prospective comparative study was conducted at the Department of Radiotherapy at Guru Gobind Singh Medical College and Hospital during a period of three months i.e. from April 2016 to June 2016. Patients were evaluated every week for a period of approximately 2 weeks. Examination of the oral cavity was done using probe and mouth mirror by trained personnel. TNM classification was used to classify tumour. Patient’s habits like alcohol and tobacco intake were also recorded. Complete demographic information was obtained from all the patients. All the data thus obtained was arranged in a tabulated form and analysed using SPSS software. Results: The study included a total of 60 subjects. There were 11 females in the study and 49 males in the study. There were 18.3% (n=11) subjects having cancer of tongue. There were 23.3% (n=14) subjects having cancer of buccal mucosa. Alveolar ridge carcinoma was seen in 8.3% (n=5) subjects. There were 22 patients (30%) having stage III carcinoma. Majority of the subjects i.e. 70% (n= 38) were at stage IV A according to TNM classification. Conclusions: From the above study we can conclude that there is lack of awareness amongst the people about oral cancer. They mostly present during advanced stage of the disease. Most of the subjects are males, showing there predisposition towards harmful habits.

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Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature

Cited by 141 publications

References 74 publications

Prevalence of HPV and EBV infection and their relationship with the p53 and PCNA expression in oral carcinoma patients.

Prevalence of HPV and EBV infection and their relationship with the p53 and PCNA expression in oral carcinoma patients.

Family History of Cancer as Surrogate Predictor for Immunotherapy with Anti-Pd1/Pd-L1 Agents: Preliminary Report of the Fami-L1 Study

Clinical findings and risk factors associated with oral cancer: a prospective study

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