Oral Candidosis as a Clinical Marker of Immune Failure in Patients with HIV/AIDS on HAART

Gaitán-Cepeda, Luis Alberto; Martínez-González, Mario; Ceballos-Salobreña, Alejandro

doi:10.1089/apc.2005.19.70

Cited by 47 publications

(38 citation statements)

References 23 publications

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“…It is well known that HIV-positive patients with CD4+ lymphocyte counts less than 200 cells/ml are severely immunocompromised and the HIV-positive patient with viral load greater than 10,000 copies/ml show active viremia [12]. In both Cases, these values are indicators of progression to AIDS.…”

Section: Discussionmentioning

confidence: 99%

“…Complete resolution was reported for a case of Kaposi's sarcoma in a 52 years old homosexual male with a primary HIV infection after being on HAART for 4 months [11]. Nearly all the reported studies had been conducted in industrialized countries and literatures concerning the behavior of HIV related oral lesions in patients undergoing HAART is scarce [12]. This study therefore aimed to determine the therapeutic effects of HAART on the clinical presentations of HIV related oral lesions in an adult Nigerian population.…”

Section: Introductionmentioning

confidence: 99%

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The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Nigeria

Taiwo¹,

Hassan

2010

AIDS Res Ther

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BackgroundThis study aimed to determine the therapeutic effects of highly active anti-retroviral therapy (HAART) on the clinical presentations of HIV related oral lesions (HIV-ROLs) in an adult Nigerian population.MethodsA 5 month prospective study on HAART naïve HIV positive adults recruited into the HAART program of an AIDS referral centre. HIV-ROLs were diagnosed clinically by the EEC Clearinghouse on oral problems related to HIV infection. Baseline clinical features of HIV-ROLs was documented by clinical photographs using SONY® 5.2 M Cybershot digital camera. Post HAART monthly review was conducted using clinical photographs.ResultsA total of 142 patients were seen. Age range was 19 - 75 years. Mean age was 35.6 ± 10.5 (SD). Eighty (56.3%) were females. Prevalence of HIV-ROLs was 43.7%. Oral candidiasis (22.4%) was the most prevalent HIV-ROL. 114 (83.2%) patients had clinical AIDS at presentation (CDC 1993). 89.4% were placed on Tenofovir/Emtricitabine +`Nevirapine, 9.9% on Tenofovir/Emtricitabine + Efavirenz. There was strong decline in the clinical features of oral candidiasis from a month of commencing HAART. Oral hairy leukoplakia was slow in responding to HAART. Parotid gland enlargement, melanotic hyperpigmentation and Kaposi's sarcoma were more persistent and had slower response to HAART. There was no clinical change noticed in linear gingival erythema.ConclusionHAART has different clinical effects on HIV related oral lesions depending on the size, duration of treatment and etiology of the lesions. HIV-ROLs of fungal origin have the fastest response to HAART. These lesions alongside immunologic parameters can be used as indicators of success or failure of antiretroviral therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Nigeria

Taiwo¹,

Hassan

2010

AIDS Res Ther

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“…Otherwise, in a recent study, Gaitán‐Cepeda et al. concluded that OC should be considered a clinical predictor of immune failure in adult patients with HIV/AIDS undergoing HAART (25).…”

Section: Introductionmentioning

confidence: 99%

Oral lesions as predictors of highly active antiretroviral therapy failure in Brazilian HIV‐infected children

Miziara

Weber

2007

J Oral Pathology Medicine

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“…For immune failure in HIV patients, oral candidiasis can be considered as clinical marker. 24 CD8+ cell count was significantly increased and the CD4+/CD8+ ratio was significantly decreased in the gingival connective tissue of the HIV+ patients which shows correlation with periodontal diseases in HIV patients. Several studies also support to our correlation between periodontal diseases and immune suppression in HIV individuals.…”

Section: Discussionmentioning

confidence: 78%

Clinical Correlation of Oral Manifestations In HIV Seropositive Patients With CD4+ Cell, CD8+Cell Counts And CD4+/CD8+ Ratio.

Karagir¹

2013

IOSR-JDMS

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Oral Candidosis as a Clinical Marker of Immune Failure in Patients with HIV/AIDS on HAART

Cited by 47 publications

References 23 publications

The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Nigeria

The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Nigeria

Oral lesions as predictors of highly active antiretroviral therapy failure in Brazilian HIV‐infected children

Clinical Correlation of Oral Manifestations In HIV Seropositive Patients With CD4+ Cell, CD8+Cell Counts And CD4+/CD8+ Ratio.

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