Oral Cancer Prevention Advances with a Translational Trial of Green Tea

Shin, Dong M.

doi:10.1158/1940-6207.capr-09-0207

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…In a prostate cancer (PCa) chemoprevention trial, green tea PPE did not reduce the likelihood of PCa in men with baseline high grade prostatic intraepithelial neoplasia and/or atypical small acinar proliferation, although the number of incidents of PCa was less in the treatment arm (27). These trials clearly demonstrate that green tea alone may not be sufficiently active for effective chemoprevention/therapy and the combination of green tea with other natural or synthetic agents has been suggested (24,25,28).…”

Section: Combination Of Resveratrol and Green Tea Epigallocatechin Gallate Induces Synergistic Apoptosis And Inhibits Tumor Growth In Vivmentioning

confidence: 88%

Combination of resveratrol and green tea epigallocatechin gallate induces synergistic apoptosis and inhibits tumor growth in vivo in head and neck cancer models

et al. 2021

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Despite widespread interest in chemoprevention and therapy due to the high margin of safety of dietary natural compounds, clinical intervention with single agents has failed to yield the expected outcomes, mostly due to poor bioavailability and low potency. Combinations of natural agents with synergistic effects are gaining increasing attention. In the present study, in vitro and in vivo antitumor effects of a combination of two natural dietary agents, green tea epigallocatechin gallate (EGCG) and resveratrol were investigated. It was revealed that their combination at low doses (at which single agents induce minimal apoptosis) synergistically increased apoptosis (combination index <1) in head and neck cancer cell lines. Synergistic apoptosis was also supported by caspase-3 and PARP cleavage. The combination also significantly inhibited growth of xenografted head and neck tumors in nude mice as supported by significant inhibition of tumor volume, tumor weight and Ki67 expression, and increase in TUNEL-positive cells. Mechanistic studies revealed that the combination inhibited AKT-mTOR signaling both in vitro and in vivo . In addition, overexpression of constitutively active AKT protected cells from apoptosis induced by the combination of EGCG and resveratrol. Collectively, the present results for the first time suggest that the combination of EGCG and resveratrol has synergistic growth inhibitory effects and provide an important rationale for future clinical development for chemoprevention and treatment of head and neck cancer.

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Section: Combination Of Resveratrol and Green Tea Epigallocatechin Gallate Induces Synergistic Apoptosis And Inhibits Tumor Growth In Vivmentioning

confidence: 88%

Combination of resveratrol and green tea epigallocatechin gallate induces synergistic apoptosis and inhibits tumor growth in vivo in head and neck cancer models

et al. 2021

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“…Therefore, the crux is to find biomarkers for early detection of oral precancerous lesions and an effective, nontoxic and affordable novel pharmacological agent in clinical trials for preventing carcinogenesis and the development of squamous cell carcinoma (SCC) as well as second primary SCC. Preventing or treating oral premalignant lesion with natural products, such as salvianolic acid B (Sal-B), ,, green tea, genistein and scutellarin or synthetic chemical agents is now one of the most promising approaches to prevent oral cancer. , Extensive studies have suggested that Salvia miltiorrhiza (Danshen) can reduce the cancer development by inducing the immunomodulatory effect, the antioxidative activity via apoptosis and inhibiting the tumor cell proliferation . Sal-B, one of its bioactive component, can inhibit the oral cancer cell proliferation in vitro and the malignant transformation from OLK to OSCC in vivo and shows promise as a COX-2 targeted anticancer agent for head and neck SCC prevention and treatment .…”

Section: Introductionmentioning

confidence: 99%

Metabolic Transformation of DMBA-Induced Carcinogenesis and Inhibitory Effect of Salvianolic Acid B and Breviscapine Treatment

Wei

Xie

et al. 2011

J. Proteome Res.

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Oral cancer typically develops from hyperplasia through dysplasia to carcinoma with a multistep process of carcinogenesis involving genetic alterations resulting in aberrant cellular appearance, deregulated cell growth, and carcinoma. The metabolic transformation during the process of oral carcinogenesis and its implications for cancer therapy have not been extensively investigated. Here, we report a metabonomic study on a classical model of 7,12-dimethylbenz(a)anthracene (DMBA)-induced oral carcinogenesis in hamsters to delineate characteristic metabolic transformation during the carcinogenesis using gas chromatography time-of-flight mass spectrometry (GC-TOF MS). Salvianolic acid B (Sal-B), isolated from Salvia miltiorrhiza Bge, and Breviscapine, a flavonoid isolated from Herba Erigerontis, were used to treat the hamsters exposed to DMBA to investigate the molecular mechanism of the inhibitory effect of the two agents on oral carcinogenesis. The dynamic changes of serum metabolic profiles indicated that both Sal-B and Breviscapine were able to attenuate DMBA-induced metabolic perturbation, which is consistent with the histopathological findings that Sal-B and Breviscapine significantly decreased the squamous cell carcinoma (SCC) incidence in the two treatment groups. Significant alterations of key metabolic pathways, including elevated glutaminolysis and glycolysis, and decreased cholesterol and myo-inositol metabolism, were observed in the DMBA-induced model group, which were attenuated or normalized by Sal-B or Breviscapine treatment. Elevated inflammation and tumor angiogenesis at gene and metabolite expression levels were also observed in DMBA-induced oral dysplasia and SCC but were attenuated or normalized by Sal-B and Breviscapine along with significantly decreased incidences of SCC formation.

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“…Topical application of green tea extract has shown to reduce thickness of oral leukoplakia. [14,15] Curcumin It is found in turmeric and gives protection against environmental dietary mutagens. Frequently used spices and herbs as antioxidants are rosemary, sesame seeds, pepper, chilli pepper and ginger.…”

Section: Mode Of Actionmentioning

confidence: 99%

Future prospective and current status of antioxidants in premalignant and malignant lesions of oral cavity

Rai¹,

Malik²,

Misra³

et al. 2014

Int J Nutr Pharmacol Neurol Dis

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In the late 19 th and early 20 th century, extensive study was devoted to the use of antioxidants in important industrial processes, such as the prevention of metal corrosion, vulcanization of rubber, and polymerization of fuels in the fouling of internal combustion engines. In recent years, there is an upsurge in the areas related to newer developments in prevention of disease, especially the role of free radicals and antioxidants. So it will be pertinent to examine the possible role of 'free radicals' in disease and 'antioxidants' in its prevention. Antioxidants are intimately involved in the prevention of cellular damage-the common pathway for cancer and a variety of diseases. The reversal or suppression of premalignant lesions is an important strategy against carcinogenesis for the prevention of cancer. Whether antioxidants can protect the human population from diseases like leukoplakia, lichen planus, carcinoma in situ or oral cancer and also from cancers of the upper aero digestive tract i.e. larynx, pharynx and esophagus and increase the life expectancy is still controversial. This article deals with the action of various chemopreventive agents along with brief review of literature about the outcome of effect of antioxidant on potentially premalignant and malignant lesions of oral mucosa.

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Oral Cancer Prevention Advances with a Translational Trial of Green Tea

Cited by 10 publications

References 32 publications

Combination of resveratrol and green tea epigallocatechin gallate induces synergistic apoptosis and inhibits tumor growth in vivo in head and neck cancer models

Combination of resveratrol and green tea epigallocatechin gallate induces synergistic apoptosis and inhibits tumor growth in vivo in head and neck cancer models

Metabolic Transformation of DMBA-Induced Carcinogenesis and Inhibitory Effect of Salvianolic Acid B and Breviscapine Treatment

Future prospective and current status of antioxidants in premalignant and malignant lesions of oral cavity

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