Oral cancer prevalence in Western population of Maharashtra, India, for a period of 5 years

Ajay, Padhiar Rutvij; Ashwinirani, SR; Nayak, Akshatha; Suragimath, Girish; Kamala, KA; Sande, Abhijeet; Naik, R

doi:10.4103/jorr.jorr_23_17

Cited by 25 publications

(13 citation statements)

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“…In the present study, buccal mucosa was the most frequent site involved by OPMDs, which is in accordance to studies by Warnakulasuriya 35 and Ajay et al 36 and in contrast to Dost et al 37 and Speight and Eng. 6 They reported that the lateral border of the tongue and the floor of the mouth were the most common sites for OPMDs.…”

Section: Discussionsupporting

confidence: 93%

Immunohistochemical Expression of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Aamir,

Rauf,

Iqbal

et al. 2024

Applied Immunohistochemistry &Amp; Molecular Morphology

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Background: Increased epidermal growth factor receptor (EGFR) expression has been implicated in several tumors and is associated with increased tumor advancement as well as a potential drug target. The objective of the study was to compare the immunohistochemical expression of EGFR in oral squamous cell carcinoma (OSCC) with oral potentially malignant disorders (OPMDs) and their demographic and pathologic parameters. Methods: This study was a comparative cross-sectional analytical study. It was conducted at the Department of Pathology, Peshawar Medical College, Riphah International University, Islamabad, Pakistan, from March 2021 to February 2022. The sample size was calculated through G Power. Thirty-eight cases of oral squamous cell carcinoma and 38 cases of oral potentially malignant disorders (OPMDs) were included in the study. Statistical analysis was performed using the Statistical Package for Social Sciences version 20.0. χ2 tests and Fisher exact tests were applied to compare categorical variables. Results: Mean age of OSCC was 61.6±13.9, with age range from 26 to 90 years. The male-to-female ratio for OSCC was 2.16:1. Buccal mucosa was the most common site involved (34.2%). The most common histologic type was well-differentiated OSCC (71.05%) followed by poorly differentiated (16%) and moderately differentiated (13.15%). The mean age of OPMDs cases was 59.16 ± 10.81 with a male-to-female ratio of 1:1.2. Buccal mucosa was the common site (55.3%), followed by the tongue (18.4%). The OPMDs with dysplasia were 55.2%, and without dysplasia were 44.8%. A total of 55.7% of cases of OSCC showed positive EGFR expression as compared with 36.9% OPMDs cases. A higher number of low-grade OSCC cases showed increased EGFR positivity (59.3%) as compared with high grade (45.45%). EGFR positivity in OPMD cases without dysplasia was 41.2% as compared with cases with dysplasia (33.3%). The EGFR expression in OPMD cases was higher in the ≤50 age group (P=0.001) and in females (P=0.032), which was statistically significant. Conclusions: EGFR expression by Immunohistochemistry may not be a helpful prognostic marker to determine the risk of OPMDs progressing to higher grades of dysplasia or invasive cancer. However, further studies relating this tumor marker to stage, lymph node metastasis, hematogenous metastasis, survival outcomes, and treatment response may give useful information regarding the utility of this marker.

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Section: Discussionsupporting

confidence: 93%

Immunohistochemical Expression of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Aamir,

Rauf,

Iqbal

et al. 2024

Applied Immunohistochemistry &Amp; Molecular Morphology

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“…A large number of studies worldwide also reported that the squamous cell carcinoma is the predominant histopathological type of oral tumour. 4,6,9,15,21,22 This endorse the findings of the present study. Histological grading and staging of tumor is the key variable that is associated strongly with the aggressiveness of any malignant tumor and their spread.…”

Section: Table I: Anatomical Distribution Of Tumor (N=143)supporting

confidence: 82%

“…and placement of these in the oral cavity. 4,6 Current study found that the commonest anatomical site of oral cancer was buccal mucosa/cavity (34.2%) followed by gums and alveolus (25.2%), tongue (14.7%) and floor of mouth (12.6%). While least common sites were lips and palate (7.0% and 6.3%) respectively.…”

Section: Table I: Anatomical Distribution Of Tumor (N=143)mentioning

confidence: 97%

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Histomorphometric features of oral tumors in Hyderabad, Pakistan.

Sajjad Ali Almani,

Safiya Javed,

Raima Kalhoro

et al. 2022

j Muhammad Med Coll

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Introduction: Oral cancers (oral cavity cancers) are the eleventh most commonly occurring cancers globally. The annual incidence of oral cancer is around 0.27 million cases while 0.13 million cases of pharyngeal cancers excluding nasopharynx occurring in developing countries. The incidence and mortality caused by these cancers show variability according to the geographic location in which it is diagnosed. Objectives: To evaluate the histomorphometric features, tumours arising at oral region, among patients in Isra University, Hyderabad. Methodology: This cross-sectional study was conducted at Isra University Hyderabad between January 2018 to December 2020. Patients; aged 18 or above of either gender; presented with chronic oral ulcer for ≥ 3 months duration, growth or swelling in the oral cavity were included in the study after taking consent. The morphological and histopathological findings of all the tissues after taking biopsy from the lesion were evaluated and finding recorded in a pre-design proforma. Results: During study period total 143 biopsies performed; 89(62.2%) were male patients while 54(37.8%) were female patients. Most (39.20%) of the patients belongs to age group of 43-52 years. Most commonly involved tumors location was the buccal mucosa/cavity (34.2%) followed by gums and alveolus (25.2%). Biopsy data after histopathological evaluation revealed that majority of patients were suffering from the squamous cell carcinoma (92.3%). Majority (35.0%) of patients were in stage II of TNM staging while half (50.3%) of the patients were in advance stages (stage III and IV). Conclusion: Buccal mucosa/cavity is the most common anatomical site for oral carcinoma with predominance of middle age group and male. Oral squamous cell carcinoma is the most prevalent oral cancer with majority of patients presented in advance stages (III and IV) and grade (II) of tumor. Keywords: Buccal mucosa, Oral tumors, Squamous cell carcinoma.

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“…Oral cavity cancer is a complex disease that arises from the normal mucosal epithelia or potentially malignant lesions (PMDs) of the upper aero-digestive tract [7]. The most common causative agents being rampant use of tobacco in various forms, betel nut chewing, chronic alcohol abuse, chronic smoking, reverse smoking, exposure to UV radiation and high-risk epitheliotropic HPV infection [7].…”

Section: Introductionmentioning

confidence: 99%

Expression of Epithelial-Mesenchymal Transition Markers in Oral Cavity Squamous Cell Cancer: An Observational Study

Solanki,

Malhotra,

Singh

et al. 2024

Preprint

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Background Epithelial-Mesenchymal transition (EMT) has evolved as a possible pathway in pathophysiology of tumor formation and progression; however, contribution of this phenomenon in human cancers especially oral malignancy lack sufficient evidence. This study aimed to evaluate the expression of EMT markers E-cadherin and N-cadherin and their correlation with clinicopathological factors in Oral Cavity Squamous Cell Cancer (OSCC). Methods This observational study was conducted on hundred histologically proven cases of OSCC based on inclusion and exclusion criteria. The expression level of Epithelial-Mesenchymal Transition markers (E-cadherin, N-cadherin) on these cases was performed and evaluated using Immunohistochemistry (IHC) staining. Expression of E-cadherin, N-cadherin was analysed and correlated with clinical and histopathological factors using appropriate statistical methods. Results Epithelial markers E-cadherin and N-cadherin were expressed in 18 (18%) and 58 (58%). Reduced expression of E-cadherin was observed in 82 (82%) patients. Significant association of N-Cadherin with clinical T-stage (p = 0.001) and clinical N-stage (p = 0.041) was observed. Pathological factors such as tumour size (p = 0.016), DOI (p = 0.001), pathological T-stage (p = 0.005) and stage (p = 0.017) showed statistically significant association with N-cadherin expression. Conclusion This study emphasizes the importance of EMT in the pathogenesis of OSCC. The use of biomarkers like E-Cadherin, N-cadherin might serve as valuable tool for developing targeted therapy in near future limiting invasion and metastasis in OSCC.

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Oral cancer prevalence in Western population of Maharashtra, India, for a period of 5 years

Cited by 25 publications

References 1 publication

Immunohistochemical Expression of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Immunohistochemical Expression of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Histomorphometric features of oral tumors in Hyderabad, Pakistan.

Expression of Epithelial-Mesenchymal Transition Markers in Oral Cavity Squamous Cell Cancer: An Observational Study

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