Oral Cancer Frequency at Different Sub Sites Presenting At a Tertiary Care Hospital in Karachi Pakistan

Siddiqui, Imtiaz Ather

doi:10.19080/gjo.2017.06.555687

Cited by 6 publications

(6 citation statements)

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“…Pakistan particularly Southern Pakistan with its capital Karachi, largest city of Pakistan, and 6 th most populous (over 20million population) in the world has shown a stunning increase in OSCC over the years that is because of excessive use of different chewing products amongst various age groups. In this study, age showed significant association with chewing habits that concurs with some studies published from Pakistan and India, reporting the mean age of the patients to be between 41–50 years [ 26 – 28 ]. In India, according to the Global Adult Tobacco Survey (GATS, 2009–2010), one-third of the Indian population ≥15 years of age use tobacco in some form [ 29 ].…”

Section: Discussionsupporting

confidence: 92%

Oral cancer: Clinicopathological features and associated risk factors in a high risk population presenting to a major tertiary care center in Pakistan

et al. 2020

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Oral squamous cell carcinoma (OSCC) has the highest prevalence in head and neck cancers and is the first and second most common cancer in males and females of Pakistan respectively. Major risk factors include peculiar chewing habits like areca nut, betel quid, and tobacco. The majority of OSCC presents at an advanced stage with poor prognosis. On the face of such a high burden of this preventable cancer, there is a relative lack of recent robust data and its association with known risk factors from Pakistan. The aim of this study was to identify the socioeconomic factors and clinicopathological features that may contribute to the development of OSCC. A total of 186 patients diagnosed and treated at a tertiary care hospital, Karachi Pakistan were recruited. Clinicopathological and socioeconomic information was obtained on a structured questionnaire. Descriptive analysis was done for demographics and socioeconomic status (SES) while regression analysis was performed to evaluate the association between SES and chewing habits, tumor site, and tumor stage. The majority of patients were males and the mean age of OSCC patients was 47.62±12.18 years. Most of the patients belonged to low SES (68.3%) and 77.4% were habitual of chewing. Gender (male) and SES were significantly associated with chewing habits (p<0.05). Odds of developing buccal mucosa tumors in chewers (of any type of substance) and gutka users were 2 and 4 times higher than non-chewers respectively. Middle age, chewing habits, and occupation were significantly associated with late stage presentation of OSCC (p<0.05). In conclusion, male patients belonging to low SES in their forties who had chewing habits for years constituted the bulk of OSCC. Buccal mucosa was the most common site in chewers and the majority presented with late stage tumors.

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Section: Discussionsupporting

confidence: 92%

Oral cancer: Clinicopathological features and associated risk factors in a high risk population presenting to a major tertiary care center in Pakistan

et al. 2020

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“…A similar trend was reported in regional data. [23] However, we believe that habit of substance abuse by men in our region is most likely reason behind high frequency of OSCC developing in male gender. [8] However, distribution of B7-H6 was rather uniform among both sexes suggesting that biomarker may not have any gender related preference.…”

Section: Resultmentioning

confidence: 73%

The IMMUNOHISTOCHEMICAL EXPRESSION OF NOVEL B7-H6 IN ORAL SQUAMOUS CELL CARCINOMA AND CORRELATION WITH HISTOLOGICAL DIFFERENTIATION AND CLINICOPATHOLOGICAL PARAMETERS

Fauzia

Syed

Baig

et al. 2019

IJMBS

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B7-H6 is a new immune checkpoint molecule related to B7 family; however, little research has been performed to determine its expression among tumors. In this study, we investigated the immunohistochemical expression of B7-H6 protein in 141 biopsy proven oral squamous cell carcinoma tissues. The specimens were subjected for immunohistochemical analysis to evaluated B7-H6 expression and was graded according to the intensity of cytoplasm and membrane staining. The distribution of B7-H6 expression was also correlated with different clinicopathological parameters of oral squamous cell carcinoma.Overall, 69 out of 141 oral squamous cell carcinoma cases had shown the expression of B7-H6 protein, majority of which belongs to moderately differentiated histological grade. This accounts for strong statistical association of B7-H6 with oral squamous cell carcinoma (P-value=0.001). The distribution of B7-H6 was also observed across broad range of clinicopathological characteristics of disease, however only long term naswar consumers have shown significant statistical difference with B7-H6 expression. We thus conclude that, B7-H6 may represent a new marker for oral squamous cell carcinoma with potential to forecast biological aggressiveness of oral squamous cell carcinoma. Hence, B7-H6 may serve as an immune target for oral squamous cell carcinoma therapy, which needs to evaluated in future studies.

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“…15 Moreover, Toscano de Brito R et al and Imtiaz AS et al also reported the higher incidence of oral cancer among male participants that are consistent with findings of the present study. 16,17 The mean age of patients in this study was 45.1±5.2 with majority 39.2% cases belong to age group 43-52 years while a considerable number of patients belongs to age 33-42 years. Although Alamgir MM et al reported highest number of cases between 41-60 years of age; yet they also found substantial number of patients in younger age bracket (31-40 years).…”

Section: Table I: Anatomical Distribution Of Tumor (N=143)mentioning

confidence: 73%

“…Published literature from India and Pakistan also showed buccal mucosa/cavity as the common site of origin. 12,14,15,[17][18][19] In contrast, tongue as commonest site of tumor have been reported by Toscano de Brito R; while alveolus followed by tongue was the commonest site reported by Baig MS. et al 16,20 Histopathological (biopsy) findings of tumors of patients in the current study revealed that that majority (92.3%) of tumors were squamous cell carcinoma while a small proportion of adenocarcinoma (3.5%), verrucous carcinoma (2.8%) and cystic carcinoma (1.4%). A large number of studies worldwide also reported that the squamous cell carcinoma is the predominant histopathological type of oral tumour.…”

Section: Table I: Anatomical Distribution Of Tumor (N=143)mentioning

confidence: 95%

Histomorphometric features of oral tumors in Hyderabad, Pakistan.

Sajjad Ali Almani,

Safiya Javed,

Raima Kalhoro

et al. 2022

j Muhammad Med Coll

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Introduction: Oral cancers (oral cavity cancers) are the eleventh most commonly occurring cancers globally. The annual incidence of oral cancer is around 0.27 million cases while 0.13 million cases of pharyngeal cancers excluding nasopharynx occurring in developing countries. The incidence and mortality caused by these cancers show variability according to the geographic location in which it is diagnosed. Objectives: To evaluate the histomorphometric features, tumours arising at oral region, among patients in Isra University, Hyderabad. Methodology: This cross-sectional study was conducted at Isra University Hyderabad between January 2018 to December 2020. Patients; aged 18 or above of either gender; presented with chronic oral ulcer for ≥ 3 months duration, growth or swelling in the oral cavity were included in the study after taking consent. The morphological and histopathological findings of all the tissues after taking biopsy from the lesion were evaluated and finding recorded in a pre-design proforma. Results: During study period total 143 biopsies performed; 89(62.2%) were male patients while 54(37.8%) were female patients. Most (39.20%) of the patients belongs to age group of 43-52 years. Most commonly involved tumors location was the buccal mucosa/cavity (34.2%) followed by gums and alveolus (25.2%). Biopsy data after histopathological evaluation revealed that majority of patients were suffering from the squamous cell carcinoma (92.3%). Majority (35.0%) of patients were in stage II of TNM staging while half (50.3%) of the patients were in advance stages (stage III and IV). Conclusion: Buccal mucosa/cavity is the most common anatomical site for oral carcinoma with predominance of middle age group and male. Oral squamous cell carcinoma is the most prevalent oral cancer with majority of patients presented in advance stages (III and IV) and grade (II) of tumor. Keywords: Buccal mucosa, Oral tumors, Squamous cell carcinoma.

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Oral Cancer Frequency at Different Sub Sites Presenting At a Tertiary Care Hospital in Karachi Pakistan

Cited by 6 publications

References 0 publications

Oral cancer: Clinicopathological features and associated risk factors in a high risk population presenting to a major tertiary care center in Pakistan

Oral cancer: Clinicopathological features and associated risk factors in a high risk population presenting to a major tertiary care center in Pakistan

The IMMUNOHISTOCHEMICAL EXPRESSION OF NOVEL B7-H6 IN ORAL SQUAMOUS CELL CARCINOMA AND CORRELATION WITH HISTOLOGICAL DIFFERENTIATION AND CLINICOPATHOLOGICAL PARAMETERS

Histomorphometric features of oral tumors in Hyderabad, Pakistan.

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