Oral bovine lactoferrin modulation on fecal microbiota of mice underwent immobilization stress

Molotla-Torres, Daniel Efrain; Hernández-Soto, Luis Mario; Guzmán-Mejía, Fabiola; Godínez‐Victoria, Marycarmen; Drago-Serrano, María Elisa; Aguirre-Garrido, José Félix

doi:10.1016/j.jff.2022.105153

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Notably, 88% of patients observed a reduction in their tumor growth rate. The research also revealed a positive correlation with the immune system through binding mechanisms [79,80]. LfcinB demonstrates potential immunomodulatory functions, influencing the host's immune response.…”

Section: Antileukemic Selectivity and Low Potential Toxicitymentioning

confidence: 80%

Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity

Lica,

Gucwa,

Heldt

et al. 2024

Molecules

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The fusion of penetrating peptides (PPs), e.g., cell penetration peptides (CPPs) or antimicrobial peptides (AMPs), together with antimicrobial agents is an expanding research field. Specific AMPs, such as lactoferricin B (LfcinB), have demonstrated strong antibacterial, antifungal, and antiparasitic activity, as well as valuable anticancer activity, proving beneficial in the development of anticancer conjugates. The resulting conjugates offer potential dual functionality, acting as both an anticancer and an antimicrobial agent. This is especially necessary in cancer treatment, where microbial infections pose a critical risk. Leukemic cells frequently exhibit altered outer lipid membranes compared to healthy cells, making them more sensitive to compounds that interfere with their membrane. In this study, we revisited and reanalyzed our earlier research on LfcinB and its conjugates. Furthermore, we carried out new experiments with a specific focus on cell proliferation, changes in membrane asymmetric phosphatidylserine location, intracellular reactive oxygen species (ROS) generation, mitochondrial functions, and in vitro bacterial topoisomerase inhibition.

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Section: Antileukemic Selectivity and Low Potential Toxicitymentioning

confidence: 80%

Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity

Lica,

Gucwa,

Heldt

et al. 2024

Molecules

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“…New tools and technological advances have demonstrated that many human illnesses are associated with dysbiosis of the gut microbiota and are greatly prompted by long-term inflammation. , To address whether a particular diet can target the gut microbiota to improve health, previous studies have established the role of LF in modulating the gut microbiota composition to influence host health. , LF–gut microbiota interactions are essential not only for the maintenance of host immunity but also for host resistance to many diseases and disorders (Figure ). Studies involving humans and animal models have linked dietary LF with weight maintenance, and decreased IBD and CVD risks, unraveling the underpinnings of the LF–gut microbiota–host axis .…”

Section: Lf Gut Microbiota and Human Health And Diseasementioning

confidence: 99%

Interaction between Dietary Lactoferrin and Gut Microbiota in Host Health

Li,

Zhang,

Zhang

et al. 2024

J. Agric. Food Chem.

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The gut microbiota are known to play an important role in host health and disease. Alterations in the gut microbiota composition can disrupt the stability of the gut ecosystem, which may result in noncommunicable chronic diseases (NCCDs). Remodeling the gut microbiota through personalized nutrition is a novel therapeutic avenue for both disease control and prevention. However, whether there are commonly used gut microbiota-targeted diets and how gut microbiota−diet interactions combat NCCDs and improve health remain questions to be addressed. Lactoferrin (LF), which is broadly used in dietary supplements, acts not only as an antimicrobial in the defense against enteropathogenic bacteria but also as a prebiotic to propagate certain probiotics. Thus, LF-induced gut microbiota alterations can be harnessed to induce changes in host physiology, and the underpinnings of their relationships and mechanisms are beginning to unravel in studies involving humans and animal models.

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Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator

Salazar

Durán

Díaz

et al. 2023

IJERPH

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The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have been thoroughly examined, and with them, their function and role in the individual’s systems. The gut microbiota’s taxonomical composition dramatically impacts older adults’ health status. In this regard, it could either extend their life expectancy via the modulation of metabolic processes and the immune system or, in the case of dysbiosis, predispose them to age-related diseases, including bowel inflammatory and musculoskeletal diseases and metabolic and neurological disorders. In general, the microbiome of the elderly tends to present taxonomic and functional changes, which can function as a target to modulate the microbiota and improve the health of this population. The GM of centenarians is unique, with the faculty-promoting metabolic pathways capable of preventing and counteracting the different processes associated with age-related diseases. The molecular mechanisms by which the microbiota can exhibit anti-ageing properties are mainly based on anti-inflammatory and antioxidant actions. This review focuses on analysing the current knowledge of gut microbiota characteristics and modifiers, its relationship with ageing, and the GM-modulating approaches to increase life expectancy.

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Oral bovine lactoferrin modulation on fecal microbiota of mice underwent immobilization stress

Cited by 3 publications

References 23 publications

Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity

Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity

Interaction between Dietary Lactoferrin and Gut Microbiota in Host Health

Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator

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