Oral bisphosphonate associated osteonecrosis of the jaws: three case reports

Malden, Nick; Pai, Ashwini

doi:10.1038/bdj.2007.636

Cited by 44 publications

(34 citation statements)

References 14 publications

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“…Bertoldo [24] and Pazianas et al [26] also found that BRONJ is a rare disease, occurring in only highdose IV administration of bisphosphonate and preventable, and they are emphasized by oral hygiene care. Though the incidence of BRONJ with oral administration of bisphosphonates is quite low, it can occur with long-term use [34][35][36][37][38]. Discontinuation of oral administration of bisphosphonates before invasive oral surgical procedures is therefore frequently recommended by oral and maxillofacial surgeons [6,8,11,12].…”

Section: Discussionmentioning

confidence: 99%

Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases

Park

Kim

et al. 2009

Osteoporos Int

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Section: Discussionmentioning

confidence: 99%

Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases

Park

Kim

et al. 2009

Osteoporos Int

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“…Some studies have found no statistically significant correlation between gender and BRONJ. 159,182 The large proportion of female patients reported in some studies 1,43,48,80,127,137,[190][191][192][193][194][195] could represent a coincidence, since women take oral BPs more frequently than males, especially because rheumatoid arthritis and osteoporosis are more common in women. 196 In accordance with other series reported in the literature, 172 the present review found a high prevalence of BRONJ among women (67.2%).…”

Section: Ae 52mentioning

confidence: 99%

Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review

Fliefel

Tröltzsch

Kühnisch

et al. 2015

International Journal of Oral and Maxillofacial Surgery

293

213

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“…BRONJ was first reported by Marx and Wang et al in 2003 5,6) , and this condition has subsequently gained much attention. In recent years, reports have increased on osteonecrosis of the jaw after dental surgery in bisphosphonate users 22,23) . BRONJ occurs at a particularly high frequency in patients using injectable bisphosphonates such as zoledronate.…”

Section: Discussionmentioning

confidence: 99%

Effects of Bisphosphonate Administration on Peri-Implant Bone in Vitamin D-Deficient Rats

Wang

Beppu

Yamamoto

et al. 2013

J. Hard Tissue Biology.

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The aim of this study was to examine histomorphologically how bisphosphonate (BP) injected before and after implant placement surgery affects the peri-implant bone in vitamin D-deficient animal model. This study used 60 six-week-old male Sprague-Dawley (SD) rats which were given a vitamin D-deficient diet. These experimental animals were divided into Group 1 (BP administration starting before implant placement), Group 2 (control group) and Group 3 (BP administration starting after implant placement). Threaded titanium implant was placed 0.50 mm mesial to the first molar. The samples were tissues from Groups 1 and 2 obtained at 1, 2, 4 and 8 weeks after implant placement and tissues from Group 3 obtained after the start of BP administration. Evaluation by light microscope and micro-CT imaging were performed. In Group 1, bone density around implants significantly increased as time progressed from after implant placement. In Group 3, bone density significantly decreased as the duration of bisphosphonate use increased. Group 1 had a significantly higher proportion of lacunae without osteocytes compared with Group 2 after implant placement. In Group 3, the proportion of these lacunae increased significantly from one to two weeks after the start of bisphosphonate administration. There were significantly higher proportions at 4 weeks and 8 weeks after the start of administration compared with 1 week after the start. This histological result suggests the need to exercise caution in using implant treatment on patients taking bisphosphonates and in administering bisphosphonates in patients after implant placement.

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Oral bisphosphonate associated osteonecrosis of the jaws: three case reports

Cited by 44 publications

References 14 publications

Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases

Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases

Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review

Effects of Bisphosphonate Administration on Peri-Implant Bone in Vitamin D-Deficient Rats

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