Oral biosciences: The annual review 2022

Ohshima, Hayato; Mishima, Kenji

doi:10.1016/j.job.2023.01.008

Cited by 2 publications

(1 citation statement)

References 226 publications

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“…SGCs represent a subset of head and neck carcinoma (HNC) super family characterized by distinct histo-genetic profiles (24). World Health Organization (WHO) tumor classification identifies a variety of SGCs including predominantly mucoepidermoid (MEC), adenoid cystic (ADCC) and salivary duct (SDC) carcinomas (25). The first category (MEC) corresponds to well-and moderately-differentiated carcinomas affecting mainly the parotid glands (26).…”

Section: Sgcs: Histo-genetic Subtypesmentioning

confidence: 99%

PTEN Deregulation Mechanisms in Salivary Gland Carcinomas

PAPANIKOLAOU,

CHRYSOVERGIS,

ADAMOPOULOU

et al. 2024

CDP

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Among the tumour suppressor genes that affect critically cell functions and homeostasis, phosphatase and tensin homolog deleted in chromosome 10 (PTEN- gene locus: 10q21) regulates the PI3K/Akt/mTOR signalling pathway. PTEN is deleted, mutated or epigenetically hyper-methylated in a variety of human solid malignancies. Salivary gland carcinomas (SGCs) belong to the head and neck carcinomas (HNCs) super category of solid malignancies. Histo-pathologically, they demonstrate a significant diversity due to a variety of distinct and mixed subtypes. Genetically, they are characterized by a broad spectrum of gene and chromosomal imbalances. Referring specifically to suppressor genes, PTEN deregulation plays a critical role in signaling transduction in the corresponding SGC pre- and malignant epithelia modifying the response rates to potential targeted therapeutic strategies. In the current review, we explored the role of PTEN deregulation mechanisms that are involved in the onset and progression of SGCs.

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Section: Sgcs: Histo-genetic Subtypesmentioning

confidence: 99%

PTEN Deregulation Mechanisms in Salivary Gland Carcinomas

PAPANIKOLAOU,

CHRYSOVERGIS,

ADAMOPOULOU

et al. 2024

CDP

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Mutational Signatures in Salivary Gland Carcinomas

Chrysovergis¹,

Papanikolaou²,

Spyropoulou³

et al. 2023

CDP

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Salivary gland carcinomas belong to the head and neck carcinoma super category of malignancies. They are characterized by histopathological diversity and comprise a variety of entities and subtypes. Mucoepidermoid, adenoid cystic and salivary duct carcinomas represent the most prominent malignancies. Concerning their corresponding genetic background, a broad spectrum of gene and chromosomal imbalances has been detected. Point mutations and deletions, amplifications and translocations, combined or not with chromosomal aneuploidy/polysomy/monosomy, create a landscape of specific genetic signatures that affect the biological behavior of these tumors and modify response rates to potential targeted therapeutic strategies. In the current molecular review, we focused on the categorization and description of the most important mutational signatures in salivary gland carcinomas.

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Oral biosciences: The annual review 2022

Cited by 2 publications

References 226 publications

PTEN Deregulation Mechanisms in Salivary Gland Carcinomas

PTEN Deregulation Mechanisms in Salivary Gland Carcinomas

Mutational Signatures in Salivary Gland Carcinomas

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