Oral biopsy and fine needle aspiration biopsy from subcutaneous fat in diagnosis of secondary amyloidosis

Sorsa, Sirkka; Happonen, Risto‐Pekka; Klemi, Pekka

doi:10.1016/s0901-5027(88)80221-2

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…A histopathological diagnosis of reactive AA amyloidosis can be established using tissue biopsy samples from the lip, kidney, rectal, or gastroduodenal mucosa, and from abdominal fat tissue 9,13,40,41 . A histopathological diagnosis of reactive AA amyloidosis can be established using tissue biopsy samples from the lip, kidney, rectal, or gastroduodenal mucosa, and from abdominal fat tissue 9,13,40,41 .…”

Section: Discussionmentioning

confidence: 99%

Effective Anti-TNF-α Therapy Can Induce Rapid Resolution and Sustained Decrease of Gastroduodenal Mucosal Amyloid Deposits in Reactive Amyloidosis Associated with Rheumatoid Arthritis

Kuroda

Wada²,

Kobayashi³

et al. 2009

J Rheumatol

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Section: Discussionmentioning

confidence: 99%

Effective Anti-TNF-α Therapy Can Induce Rapid Resolution and Sustained Decrease of Gastroduodenal Mucosal Amyloid Deposits in Reactive Amyloidosis Associated with Rheumatoid Arthritis

Kuroda

Wada²,

Kobayashi³

et al. 2009

J Rheumatol

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“…Several less invasive procedures have been tried, including rectal biopsies, abdominal fat aspiration biopsies and gastroduodenal biopsies [8][9][10]. However, these procedures have produced widely varying estimates of the incidence of amyloidosis in RA patients, and the correlation between their results and those of renal biopsies is not clear.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Gastroduodenal, Renal and Abdominal Fat Biopsies for Diagnosing Amyloidosis in Rheumatoid Arthritis

et al. 2002

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The aim of the study was to determine the frequency of amyloidosis detected by gastroduodenal biopsy in rheumatoid arthritis (RA) patients, and to investigate correlations between the results of gastroduodenal biopsy and abdominal fat and renal biopsies. A total of consecutive 1006 RA patients underwent gastroduodenal biopsy. The 71 patients who tested positive for gastrointestinal (GI) amyloidosis were asked to undergo renal and abdominal fat biopsies, and 21 did so. Renal biopsies were also performed on 12 patients with no amyloidosis but indicators of drug-induced renal damage, and abdominal fat biopsies were performed on 50 RA patients with no indication of amyloidosis. The prevalence of GI amyloidosis was 7.1%. Urinary abnormalities and GI symptoms were common in GI amyloidisis, and inflammatory markers were elevated. Sixty-one (86%) had either depressed creatinine clearance or urinary symptoms. Nineteen of the 21 patients (91%) with GI amyloidosis who underwent renal biopsies also had renal amyloid deposits. Eleven of the 21 (52%) had amyloidosis on abdominal fat biopsy. None of the 12 patients without GI amyloidosis had renal amyloidosis on renal biopsy, and none of the 50 patients without GI amyloidosis had amyloidosis on abdominal fat biopsy. Gastroduodenal biopsy reveals a high prevalence of amyloidosis in RA patients. Amyloidosis is often associated with signs of renal impairment. Results of GI biopsy are highly correlated with those of renal biopsy, but the results of fat biopsy are not. We recommend GI biopsy for RA patients for the screening of systemic amyloidosis.

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“…A clinical diagnosis of amyloidosis is usually suspected with the onset of proteinuria, renal insufficiency and diarrhea. The histological diagnosis of reactive amyloidosis is generally established by lip, renal, rectal, abdominal fat aspiration, and gastrointestinal (GI) biopsy [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Programmed initiation of hemodialysis for systemic amyloidosis patients associated with rheumatoid arthritis

et al. 2010

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Reactive amyloidosis is a serious systemic disease in rheumatoid arthritis (RA). Amyloid protein can be deposited in kidneys, heart or gastrointestinal tract leading to organ failure. Renal involvement is a well-known complication in amyloidosis as this may culminate in end-stage renal disease (ESRD). Hemodialysis (HD) is always considered the treatment of choice for such patients; however, the prognosis is usually poor due to a large number of sudden deaths immediately following HD therapy. To circumvent the problem of HD initiation while instituting HD safety, we devised a plan to start HD and compare patient's survival with our previous data. Sixty-three patients were treated with HD. They were categorized according to the initiation of first dialysis. All patients were divided into planned, unplanned and programmed initiation groups. First dialysis that had been initiated as not urgent was considered 'planned' (20 patients). First dialysis that had been performed urgently for life-threatening renal insufficiency was considered 'unplanned' (31 patients). First dialysis that had been initiated as not urgent and according to our dialysis program was considered 'programmed' (12 patients). Survival of these 63 patients from the initiation of HD at 38 days was 75%, at 321 days was 50% and at 1,784 days was 25%. Patients with unplanned initiation of HD showed a significant poor survival compared with those of both planned and programmed initiation. Additionally, patients with planned and programmed initiation of HD showed no significant difference for the patients' survival. Our study demonstrates that patients with amyloidosis have a higher mortality rate. Nevertheless, programmed initiation of HD will improve the prognosis of patients with ESRD. Such possibility needs to be considered in more detail in the future.

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Oral biopsy and fine needle aspiration biopsy from subcutaneous fat in diagnosis of secondary amyloidosis

Cited by 7 publications

References 7 publications

Effective Anti-TNF-α Therapy Can Induce Rapid Resolution and Sustained Decrease of Gastroduodenal Mucosal Amyloid Deposits in Reactive Amyloidosis Associated with Rheumatoid Arthritis

Effective Anti-TNF-α Therapy Can Induce Rapid Resolution and Sustained Decrease of Gastroduodenal Mucosal Amyloid Deposits in Reactive Amyloidosis Associated with Rheumatoid Arthritis

Comparison of Gastroduodenal, Renal and Abdominal Fat Biopsies for Diagnosing Amyloidosis in Rheumatoid Arthritis

Programmed initiation of hemodialysis for systemic amyloidosis patients associated with rheumatoid arthritis

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