Oral Bioavailability

Cave, Mark; Wragg, Joanna; Denys, Sébastien; Jondreville, Catherine; Feidt, Cyril

doi:10.1007/978-90-481-9757-6_7

Cited by 15 publications

(6 citation statements)

References 137 publications

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“…Chronic exposure of humans to As may cause a myriad of symptoms, including several forms of cancer, cardiovascular diseases, suppressed hormone regulation and DNA replication, neurological disorders, and skin lesions. , Incidental oral ingestion of contaminated soil represents a key exposure pathway in human health risk assessments for As, which is especially relevant for children due to their mouthing behavior or the direct ingestion of contaminated soil. , Once ingested, the actual health risk depends on the bioavailability of As, defined as the fraction of As which is absorbed from the gastrointestinal tract via the intestinal epithelium into the systemic circulation. In contrast, bioaccessibility (BA) refers to the fraction of contaminant soluble in the gastrointestinal tract and available for entrance to the systemic circulation. ,, In-vitro chemical tests simulating the gastrointestinal environment of humans are increasingly employed as rapid screening tools in assessing the (potential) bioavailability of metal(loid)s at contaminated sites . Methods like the physiologically based extraction test (PBET) or the in-vitro gastrointestinal (IVG) extraction provide cost-effective alternatives to lengthy and ethically questionable animal dosing trials and have been validated by several animal model studies. , …”

Section: Introductionmentioning

confidence: 99%

Bioaccessibility of Arsenic in Mining-Impacted Circumneutral River Floodplain Soils

Mikutta

Mandaliev

Mahler

et al. 2014

Environ. Sci. Technol.

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Floodplain soils are frequently contaminated with metal(loid)s due to present or historic mining, but data on the bioaccessibility (BA) of contaminants in these periodically flooded soils are scarce. Therefore, we studied the speciation of As and Fe in eight As-contaminated circumneutral floodplain soils (≤ 21600 mg As/kg) and their size fractions using X-ray absorption spectroscopy (XAS) and examined the BA of As in the solids by in-vitro gastrointestinal (IVG) extractions. Arsenopyrite and As(V)-adsorbed ferrihydrite were identified by XAS as the predominant As species. The latter was the major source for bioaccessible As, which accounted for 5-35% of the total As. The amount of bioaccessible As increased with decreasing particle size and was controlled by the slow dissolution kinetics of ferrihydrite in the gastric environment (pH 1.8). The relative BA of As (% of total) decreased with decreasing particle size only in a highly As-contaminated soil--which supported by Fe XAS--suggests the formation of As-rich hydrous ferric oxides in the gastric extracts. Multiple linear regression analyses identified Al, total As, C(org), and P as main predictors for the absolute BA of As (adjusted R(2) ≤ 0.977). Health risk assessments for residential adults showed that (i) nearly half of the bulk soils may cause adverse health effects and (ii) particles <5 μm pose the highest absolute health threat upon incidental soil ingestion. Owing to their low abundance, however, health risks were primarily associated with particles in the 5-50 and 100-200 μm size ranges. These particles are easily mobilized from riverbanks during flooding events and dispersed within the floodplain or transported downstream.

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Section: Introductionmentioning

confidence: 99%

Bioaccessibility of Arsenic in Mining-Impacted Circumneutral River Floodplain Soils

Mikutta

Mandaliev

Mahler

et al. 2014

Environ. Sci. Technol.

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“…Unified BARGE Method (UBM) was developed by the BARGE (Bioaccessibility Research Group of 96 Europe) research group (Wragg et al, 2011) and has been validated against in vivo studies for As, Pb and 97…”

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confidence: 99%

Mineralogical characterisation to improve understanding of oral bioaccessibility of Cr and Ni in basaltic soils in Northern Ireland

Cox

Rollinson

McKinley

2017

Journal of Geochemical Exploration

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18Underlying bedrock is often the source of elevated levels of potentially toxic elements (PTEs) (including 19 Ni and Cr) in soils, which can be at concentrations exceeding regulatory guidelines for the protection of 20 human health. However geogenic contaminants are often not significantly bioavailable to humans as 21 they are bound tightly within the soil matrix. Therefore oral bioaccessibility testing can be used to 22 Highlights 42  Ni and Cr analysis of Basaltic soils overlying Antrim Basalts of Northern Ireland 43  Combined chemical and mineralogical data for improved understanding 44  High resolution analysis of samples, consistent across analytical methods 45  Bioaccessible Ni in precursor clay minerals, secondary Fe-oxides and carbonates 46  Low Cr bioaccessibility as Cr predominantly in chrome spinel and primary Fe-oxides 47 mineralogy of soils overlying the Antrim Basalts is characterised using both quantitative XRD and 127 QEMSCAN ® analyses combined with detailed geochemical data; 2) detailed elemental and mineralogical 128 mapping are compared to determine which minerals host total Ni and Cr; and 3) this information is 129 related to results of previous bioaccessibility testing (Barsby et al., 2012) and non-specific sequential 130 extractions (Cox et al., 2013) to elucidate how the oral bioaccessibility of both Ni and Cr is affected by 131 soil composition. 132 133

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“…For investigation into the hand‐to‐mouth incidental soil ingestion, a <250‐μm fraction has been traditionally used (e.g., Cave et al., 2011 ; Pelfrêne et al., 2011 ; US EPA, 2007 ). Based on a literature review by Ruby and Lowney ( 2012 ), the United Sates Environmental Protection Agency (US EPA) decided to lower the particle size fraction to <150 μm for the bioaccessibility testing (Test Method 1340; US EPA, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

Contaminant Binding and Bioaccessibility in the Dust From the Ni‐Cu Mining/Smelting District of Selebi‐Phikwe (Botswana)

et al. 2022

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We studied the dust fractions of the smelting slag, mine tailings, and soil from the former Ni‐Cu mining and processing district in Selebi‐Phikwe (eastern Botswana). Multi‐method chemical and mineralogical investigations were combined with oral bioaccessibility testing of the fine dust fractions (<48 and <10 μm) in a simulated gastric fluid to assess the potential risk of the intake of metal(loid)s contaminants. The total concentrations of the major contaminants varied significantly (Cu: 301–9,600 mg/kg, Ni: 850–7,000 mg/kg, Co: 48–791 mg/kg) but were generally higher in the finer dust fractions. The highest bioaccessible concentrations of Co, Cu, and Ni were found in the slag and mine tailing dusts, where these metals were mostly bound in sulfides (pentlandite, pyrrhotite, chalcopyrite). On the contrary, the soil dusts exhibited substantially lower bioaccessible fractions of these metals due to their binding in less soluble spinel‐group oxides. The results indicate that slag dusts are assumed to be risk materials, especially when children are considered as a target group. Still, this exposure scenario seems unrealistic due to (a) the fencing of the former mine area and its inaccessibility to the local community and (b) the low proportion of the fine particles in the granulated slag dump and improbability of their transport by wind. The human health risk related to the incidental ingestion of the soil dust, the most accessible to the local population, seems to be quite limited in the Selebi‐Phikwe area, even when a higher dust ingestion rate (280 mg/d) is considered.

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Oral Bioavailability

Cited by 15 publications

References 137 publications

Bioaccessibility of Arsenic in Mining-Impacted Circumneutral River Floodplain Soils

Bioaccessibility of Arsenic in Mining-Impacted Circumneutral River Floodplain Soils

Mineralogical characterisation to improve understanding of oral bioaccessibility of Cr and Ni in basaltic soils in Northern Ireland

Contaminant Binding and Bioaccessibility in the Dust From the Ni‐Cu Mining/Smelting District of Selebi‐Phikwe (Botswana)

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