Oral beclomethasone dipropionate in chronic refractory pouchitis

Gionchetti, Paolo; Calabrese, Carlo; Calafiore, A.; Praticò, Chiara; Poggioli, Gilberto; Laureti, Silvio; Capozzi, Nunzia; Campieri, Massimo; Rizzello, Fernando

doi:10.1016/j.crohns.2013.12.001

Cited by 40 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gionchetti et al ., conducted an open‐label nonrandomised study in 10 consecutive patients with chronic pouchitis who were treated with beclomethasone 10 mg/day for 8 weeks. Current active refractory pouchitis was defined as a PDAI score of ≥7 and no response to at least 4 weeks of standard antibiotic treatment (ciprofloxacin 1 g once a day or metronidazole 1 g once a day).…”

Section: Effects Of Interventionsmentioning

confidence: 99%

Systematic review with meta‐analysis: the management of chronic refractory pouchitis with an evidence‐based treatment algorithm

Segal

Ding

Worley

et al. 2016

Aliment Pharmacol Ther

100

View full text Add to dashboard Cite

show abstract

Section: Effects Of Interventionsmentioning

confidence: 99%

Systematic review with meta‐analysis: the management of chronic refractory pouchitis with an evidence‐based treatment algorithm

Segal

Ding

Worley

et al. 2016

Aliment Pharmacol Ther

100

View full text Add to dashboard Cite

show abstract

“…To treat chronic pouchitis, a combination of oral antibiotics, 60,61 budesonide, 62 topical tacrolimus, 63 or beclomethasone dipropionate 64 are available ( Table 3, Fig. 3).…”

Section: Chronic Pouchitismentioning

confidence: 99%

Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment

2021

View full text Add to dashboard Cite

patients can be diagnosed with Crohn' s disease (CD) of the pouch. 6 In this review, we discuss the diagnosis and prognosis of pouchitis, risk factors for pouchitis development, and treatment options for pouchitis, including the newer biological agents. CLINICAL COURSE AND DIAGNOSIS OF POUCHITIS Pouchitis is classified as acute or chronic pouchitis. 7 Acute pouchitis is defined as symptoms lasting less than 4 weeks and responding to 2-week courses of antibiotics. Chronic pouchitis is defined as having symptoms lasting longer than 4 weeks despite standard antibiotic courses and requiring chronic antibiotics or anti-inflammatory therapy. 3 Approximately 10% to 15% of patients with acute pouchitis develop chronic pouchitis which has subgroups such as antibiotic-dependent and antibiotic-refractory pouchitis. 7,8 The diagnosis of pouchitis is based on the combined assessment of symptoms, endoscopic, and histologic findings.

show abstract

“…Beclomethasone dipropionate, at a higher dose than is usual (10 mg daily) for 8 weeks, was also effective in another open-label study in antibiotic-refractory patients. 29…”

Section: What Is the Treatment For Chronic Pouchitis?mentioning

confidence: 99%

Pouchitis: Treatment dilemmas at different stages of the disease

et al. 2020

View full text Add to dashboard Cite

Pouchitis is a frequent complication in ulcerative colitis patients after proctocolectomy with ileal pouch–anal anastomosis. It is an unspecific inflammation of the pouch with unknown aetiology. First-line treatment for acute and chronic pouchitis is antibiotics. Some cases of severe chronic refractory pouchitis may benefit from biological treatment. Anti-tumour necrosis factor should be recommended as the first option, leaving the new biologicals for multirefractory patients. Permanent ileostomy may be an option in severe cases, after failure of medical treatment. Prophylaxis therapy with a probiotic mixture is recommended after the first episode of pouchitis, whereas it is not clear whether probiotics are useful for all patients after surgery. Here, we present a case report and review the treatment options in different forms of pouchitis.

show abstract

Oral beclomethasone dipropionate in chronic refractory pouchitis

Abstract: Eight-week treatment with oral beclomethasone dipropionate appears effective in inducing remission in patients with active pouchitis refractory to antibiotic treatment.

Cited by 40 publications

References 28 publications

Systematic review with meta‐analysis: the management of chronic refractory pouchitis with an evidence‐based treatment algorithm

Systematic review with meta‐analysis: the management of chronic refractory pouchitis with an evidence‐based treatment algorithm

Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment

Pouchitis: Treatment dilemmas at different stages of the disease

Contact Info

Product

Resources

About