Oral bacteria in the occluded arteries of patients with Buerger disease

Iwai, Takehisa; Inoue, Yasuhiro; Umeda, Makoto; Huang, Yi; Kurihara, Nobuhisa; Koike, Masato; Ishikawa, Isao

doi:10.1016/j.jvs.2005.03.016

Cited by 150 publications

(118 citation statements)

References 39 publications

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“…Our group and others have detected these periodontopathic bacteria in lesions with atherosclerotic plaque and Buerger's disease [18,40,41]. We also compared periodontal pathogen detection rates in stenotic coronary artery plaque from patients with four or more periodontal lesions with those in patients with fewer than four lesions.…”

Section: Discussionmentioning

confidence: 99%

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Okuda

Kimizuka

Miyamoto

et al. 2007

Microbes and Infection

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Treponema denticola, a major pathogen of periodontitis, has also been detected in the lesions of atherosclerosis. The aim of this study was to investigate induction of chemokine production in human umbilical vein endothelial cells (HUVECs) by T. denticola and determine whether those chemokines were degraded by a protease, dentilisin. T. denticola ATCC35405 or dentilisin-deficient mutant K1 were added to HUVECs and levels of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in the culture supernatants were determined by enzyme-linked immunosorbent assay. T. denticola ATCC35405 induced production of IL-8 in a time-dependent manner, with both production of IL-8 and expression of IL-8 mRNA showing higher levels than with exposure to dentilisin-deficient mutant K1. Although exposure to ATCC35405 induced expression of MCP-1 mRNA in the HUVECs, MCP-1 levels were remained similar to that in unstimulated cells. IL-8 and MCP-1 showed partial hydrolysis with exposure to T. denticola ATCC35405, but not with T. denticola K1. These results suggest that T. denticola can evade host defense mechanisms by modulating production of IL-8 and MCP-1, and that this play a role in the development of chronic infections such as periodontitis. The association of T. denticola infection to atherosclerosis was also discussed based on the present study.-3 -

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Section: Discussionmentioning

confidence: 99%

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Okuda

Kimizuka

Miyamoto

et al. 2007

Microbes and Infection

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“…Over 47% of American adults suffer from periodontitis, the most common infectious disease in humans (3). In addition to dental diseases, recent studies have also reported that P. gingivalis is related with systemic diseases, such as cardiovascular diseases (4), decreased kidney function (5), and rheumatoid arthritis (6). The bacterium does not ferment carbohydrates, but grows under strict anaerobic conditions using proteinaceous substrates as carbon and energy sources.…”

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confidence: 99%

Identification and Characterization of Prokaryotic Dipeptidyl-peptidase 5 from Porphyromonas gingivalis

Ohara‐Nemoto

Rouf

Naito

et al. 2014

Journal of Biological Chemistry

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Background: Dipeptidyl-peptidases (DPPs) are key factors for amino acid metabolism and bacterial growth of asaccharolytic Porphyromonas gingivalis. Results: DPP5, which is specific for Ala and hydrophobic residues, is expressed in the periplasmic space of P. gingivalis. Conclusion: DPP5 was discovered in prokaryotes for the first time. Significance: The discovery of DPP5 expands understanding of amino acid and energy metabolism in prokaryotes.

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“…6,7) Our previous investigation detected several species of periodontal bacteria in aneurysmal walls and thrombi of patients with abdominal aortic aneurysms 8) or Buerger disease. 9) Inflammation within the atherosclerotic plaque may lead to plaque destabilization, 10) and dental plaque bacteria may also contribute to this destabilization. There are few studies that have investigated the periodontal infections in ACS and chronic CHD.…”

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confidence: 99%

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

et al. 2007

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SUMMARYRecent epidemiological studies suggest that periodontitis is an important risk factor for coronary heart disease (CHD). The aim of this study was to evaluate the association between periodontitis and CHD, particularly acute coronary syndrome (ACS), focusing on microbiological and immunological features.Twenty-eight CHD patients, 15 with ACS and 13 with chronic CHD, were included in this study. Coronary angiography, periodontal examination, and dental radiography were performed in all patients. Subgingival plaque, saliva, and blood samples were analyzed for the periodontopathogens Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia using polymerase chain reaction.Specific serum antibody titers to the 5 periodontal pathogens were determined by enzyme-linked immunosorbent assay. It was found that 33% of the ACS patients (5/15) harbored A. actinomycetemcomitans in oral samples, whereas no A. actinomycetemcomitans (0/13) was found in the chronic CHD patients (P < 0.05). Furthermore, ACS patients showed significantly higher serum IgG titers to A. actinomycetemcomitans (P < 0.05) compared with chronic CHD. More tooth loss and alveolar bone loss were noted in ACS patients than in chronic CHD patients, although the differences were not statistically significant.Periodontal pathogens, particularly A. actinomycetemcomitans, may play a role in the development of ACS. (Int Heart J 2007; 48: 663-675)

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Oral bacteria in the occluded arteries of patients with Buerger disease

Abstract: This is the first study to identify oral microorganisms in the lesions of Buerger disease. Our findings suggest a possible etiologic link between Buerger disease and chronic infections such as oral bacterial infections.

Cited by 150 publications

References 39 publications

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Identification and Characterization of Prokaryotic Dipeptidyl-peptidase 5 from Porphyromonas gingivalis

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

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