Oral Bacille Calmette-Guérin (BCG) vaccination induces long-term potentiation of memory immune response to Ovalbumin airway challenge in mice.

Hammes, Andreza; Cardillo, Fabı́ola; Frota, Rodolfo; Pinho, Rosa Teixeira de; Mengel, José

doi:10.1016/j.imlet.2022.08.004

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…An example of an enhanced innate immune response improving adaptive immunity is the BCG vaccine, which induces trained innate immunity and also promotes increased adaptive immune responses (humoral and cellular immunity) to heterologous vaccines. [220][221][222][223] Thus, we hypothesize that the immaturity of the innate immune system could be involved in the impaired adaptive immune response as well as the inconsistency observed in the capacity of foals to mount a Th1 immune response. 3,7,89 Environmental stimuli appear to play a role in maturing the foal innate immune response, 95,107 and, consequently, facilitating the development of adaptive immunity.…”

Section: Cooperation Of Innate Immunity and Adaptive Immunity Against...mentioning

confidence: 99%

Protective immune responses against Rhodococcus equi : an innate immunity-focused review

Bordin,

Silveira,

Cohen

et al. 2024

Preprint

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Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review was to summarize the current understanding of interactions between R. equi and the host innate immune system, to describe features of the immune response that are associated with resistance or susceptibility to R. equi infection, and help guide strategies for developing novel approaches for preventing R. equi infections. Virulence of R. equi in foals has been attributed to the virulence associated protein A which allows intracellular survival in macrophages by preventing acidification of R. equi-containing vacuole. Additionally, foal susceptibility to R. equi infection is associated with immaturity and naivety of innate and adaptive immune systems, while adult horses with fully functional immune system are resistant to pneumonia. Specific interaction between R. equi and innate immune cells can result in bacterial survival or death; learning how to manipulate these responses to control infection is critical to prevent pneumonia in foals. Administration of live vaccines and stimulation of innate immune responses appears to improve foals’ immune response and has the potential to overcome the challenges of foal active vaccination and elicit protection against pneumonia.

show abstract

Section: Cooperation Of Innate Immunity and Adaptive Immunity Against...mentioning

confidence: 99%

Protective immune responses against Rhodococcus equi : an innate immunity-focused review

Bordin,

Silveira,

Cohen

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Acidified sucralfate encapsulated chitosan derivative nanoparticles as oral vaccine adjuvant delivery enhancing mucosal and systemic immunity

Zhao,

Qiao,

Jin

et al. 2024

International Journal of Biological Macromolecules

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Protective immune response against Rhodococcus equi: An innate immunity‐focused review

da Silveira,

Cohen,

Lawhon

et al. 2024

Equine Veterinary Journal

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Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune system, to describe features of the immune response that are associated with resistance or susceptibility to R. equi infection, and help guide strategies for developing novel approaches for preventing R. equi infections. Virulence of R. equi in foals has been attributed to the virulence associated protein A which allows intracellular survival in macrophages by preventing acidification of R. equi‐containing vacuole. Additionally, foal susceptibility to R. equi infection is associated with immaturity and naivety of innate and adaptive immune systems, while adult horses with fully functional immune system are resistant to pneumonia. Specific interaction between R. equi and innate immune cells can result in bacterial survival or death; learning how to manipulate these responses to control infection is critical to prevent pneumonia in foals. Administration of live vaccines and stimulation of innate immune responses appears to improve foals' immune response and has the potential to overcome the challenges of foal active vaccination and elicit protection against pneumonia.

show abstract

Oral Bacille Calmette-Guérin (BCG) vaccination induces long-term potentiation of memory immune response to Ovalbumin airway challenge in mice.

Cited by 4 publications

References 40 publications

Protective immune responses against Rhodococcus equi : an innate immunity-focused review

Protective immune responses against Rhodococcus equi : an innate immunity-focused review

Acidified sucralfate encapsulated chitosan derivative nanoparticles as oral vaccine adjuvant delivery enhancing mucosal and systemic immunity

Protective immune response against Rhodococcus equi: An innate immunity‐focused review

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