Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation

Zhang, Q.; Ai, Chunqing; Wang, Guanchao; Liu, X.; Tian, Fengwei; Zhao, Jianxin; Zhang, H.; Chen, Y.Q.; Chen, Wei

doi:10.1111/jam.12885

Cited by 13 publications

(7 citation statements)

References 45 publications

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“…This could be explained by the antibiotic-induced decrease in diversity of lung microbiota which has been linked to BPD development [ 81 ]. Probiotics are known to restore intestinal microbiota after antibiotic therapy [ 82 ] and to produce a strong suppressive effect on airway inflammation [ 83 ]. Lastly, poor nutrition is associated with lung underdevelopment and the occurrence of BPD [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

Probiotic Supplementation in Preterm Infants Does Not Affect the Risk of Bronchopulmonary Dysplasia: A Meta-Analysis of Randomized Controlled Trials

et al. 2017

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Probiotic supplementation reduces the risk of necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in preterm infants, but it remains to be determined whether this reduction translates into a reduction of other complications. We conducted a systematic review and meta-analysis to evaluate the possible role of probiotics in altering the risk of bronchopulmonary dysplasia (BPD). Fifteen randomized controlled trials (4782 infants; probiotics: 2406) were included. None of the included studies assessed BPD as the primary outcome. Meta-analysis confirmed a significant reduction of NEC (risk ratio (RR) 0.52, 95% confidence interval (CI) 0.33 to 0.81, p = 0.004; random effects model), and an almost significant reduction of LOS (RR 0.82, 95% CI 0.65 to 1.03, p = 0.084). In contrast, meta-analysis could not demonstrate a significant effect of probiotics on BPD, defined either as oxygen dependency at 28 days of life (RR 1.01, 95% CI 0.91 to 1.11, p = 0.900, 6 studies) or at 36 weeks of postmenstrual age (RR 1.07, 95% CI 0.96 to 1.20, p = 0.203, 12 studies). Meta-regression did not show any significant association between the RR for NEC or LOS and the RR for BPD. In conclusion, our results suggest that NEC and LOS prevention by probiotics does not affect the risk of developing BPD in preterm infants.

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Section: Discussionmentioning

confidence: 99%

Probiotic Supplementation in Preterm Infants Does Not Affect the Risk of Bronchopulmonary Dysplasia: A Meta-Analysis of Randomized Controlled Trials

et al. 2017

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“…The mRNA expression level of Foxp3 in lung tissues was analyzed by RT-PCR as previous description [ 19 ]. Briefly, total RNA was isolated from liquid nitrogen-frozen tissues with Trizol ® reagent, and reverse transcription into cDNA was performed by the QuantScript RT Kit (TIANGEN, China).…”

Section: Methodsmentioning

confidence: 99%

Immunomodulatory Effects of Different Lactic Acid Bacteria on Allergic Response and Its Relationship with In Vitro Properties

Zhang

et al. 2016

PLoS ONE

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Some studies reported that probiotic could relieve allergy-induced damage to the host, but how to get a useful probiotic is still a challenge. In this study, the protective effects of three lactic acid bacteria (La, Lp and Lc) were evaluated in a mouse model, and its relationship with the in vitro properties was analyzed. The in vitro results indicated that La with the capacity to inhibit IL-4 production could have a better anti-allergy effect in vivo than two others. However, the animal trials showed that all LAB strains could alleviate allergen-induced airway inflammation. Among them, LAB strain Lp had a better effect in inhibiting allergic response through a modulation of Th1/Th2 balance and an increase of regulatory T cells. This difference could be explained by that different LAB strains have a strain-specific effect on gut microbiota closely associated with host immune responses. Finally, this study did not only obtain an effective anti-allergy probiotic strain via animal study, but also indicate that probiotic-induced effect on intestinal microbiota should be considered as an important screening index, apart from its inherent characteristics.

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“…Two probiotics Phaeobacter inhibens S4Sm and Bacillus pumilus RI06-95Sm in black molly, have been shown to colonize in intestine and reverse mortality caused by streptomycin by inhibiting Vibrio anguillarum [121], which are known opportunistic pathogens in fish [128] and are thought to be “r-strategists” capable of rapid growth and virulence in disturbed microbial communities [129,130]. (2) Improving immune function of host by enhancing anti-inflammation [131,132,133,134]. Shi et al (2017) used two Lactobacillus cocktails (LacA and LacB, each contains four strains) to restore the cefixime-induced GM disturbance in mice, and alleviate intestinal inflammation possibly due to beneficial SCFAs production [134].…”

Section: Probiotics As a Potential Tool In Contaminants Remediationmentioning

confidence: 99%

A Review on Gut Remediation of Selected Environmental Contaminants: Possible Roles of Probiotics and Gut Microbiota

et al. 2018

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Various environmental contaminants including heavy metals, pesticides and antibiotics can contaminate food and water, leading to adverse effects on human health, such as inflammation, oxidative stress and intestinal disorder. Therefore, remediation of the toxicity of foodborne contaminants in human has become a primary concern. Some probiotic bacteria, mainly Lactobacilli, have received a great attention due to their ability to reduce the toxicity of several contaminants. For instance, Lactobacilli can reduce the accumulation and toxicity of selective heavy metals and pesticides in animal tissues by inhibiting intestinal absorption of contaminants and enhancing intestinal barrier function. Probiotics have also shown to decrease the risk of antibiotic-associated diarrhea possibly via competing and producing antagonistic compounds against pathogenic bacteria. Furthermore, probiotics can improve immune function by enhancing the gut microbiota mediated anti-inflammation. Thus, these probiotic bacteria are promising candidates for protecting body against foodborne contaminants-induced toxicity. Study on the mechanism of these beneficial bacterial strains during remediation processes and particularly their interaction with host gut microbiota is an active field of research. This review summarizes the current understanding of the remediation mechanisms of some probiotics and the combined effects of probiotics and gut microbiota on remediation of foodborne contaminants in vivo.

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Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation

Abstract: The rise in incidence in allergies may correlate with the widespread and liberal use of antibiotics. This study affirmed that one species of LAB ST218 significantly reduces allergic airway inflammation in antibiotic-treated mice model.

Cited by 13 publications

References 45 publications

Probiotic Supplementation in Preterm Infants Does Not Affect the Risk of Bronchopulmonary Dysplasia: A Meta-Analysis of Randomized Controlled Trials

Probiotic Supplementation in Preterm Infants Does Not Affect the Risk of Bronchopulmonary Dysplasia: A Meta-Analysis of Randomized Controlled Trials

Immunomodulatory Effects of Different Lactic Acid Bacteria on Allergic Response and Its Relationship with In Vitro Properties

A Review on Gut Remediation of Selected Environmental Contaminants: Possible Roles of Probiotics and Gut Microbiota

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