Oral antioxidants supplementation for women with unexplained infertility undergoing ICSI/IVF: Randomized controlled trial

Youssef, Mohamed; Abdelmoty, Hatem I.; Elashmwi, Hazem A.; Abduljawad, Esaad M.; Elghamary, Nevin; Magdy, Ahmed; Mohesen, Mohamed N.; Abdella, Rana; Bar, Mostafa Abdel; Gouda, Hisham M.; Ali, Ahmed M.; Raslan, Ayman N.; Youssef, Dalia; Sherif, Nadin A.; Ismail, Aboulfoutouh I.

doi:10.3109/14647273.2014.927595

Cited by 29 publications

(27 citation statements)

References 20 publications

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“…A study carried out in women undergoing IVF showed that, vitamin E present in the follicular fluid or serum, is related to higher oocyte maturation and higher quality embryos rates [ 123 ]. In particular, 0.35/1 mg/dL and 1.5/2 mg/dL are the levels of vitamin E in follicular fluid that allowed achieving the highest percentage of MII oocytes [ 123 ]. Similarly, 10/15 mg/dL serum level of vitamin E was related to the highest percentage of higher quality of embryos obtained [ 123 ].…”

Section: Agents Consideredmentioning

confidence: 99%

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Budani

Tiboni

2020

Antioxidants

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For most infertile couples, in vitro fertilization (IVF) represents the only chance to conceive. Given the limited success of IVF procedures, novel approaches are continuously tested with the aim of improving IVF outcomes. Growing attention is devoted today to the potential benefit of natural antioxidants in the optimization of infertility treatments. This review summarizes current data in this context, focusing on both experimental studies on oocytes/embryos and clinical trials on antioxidants supplementation. Based on information gained from experimental studies, antioxidant supplementation may have beneficial effects on IVF outcomes in terms of quality and cryotolerance of in vitro produced embryos, together with positive effects on in vitro maturation oocytes and on early embryonic development. Unfortunately, from the clinical side, there is a paucity of evidence favoring the protective qualities of antioxidants. Among the antioxidants considered, coenzyme Q10 may be regarded as one of the most promising for its positive role in rescuing the oxidative stress-induced damages, but further data are needed. It is concluded that further trials are necessary to characterize the potential clinical value of antioxidants in IVF treatments.

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Section: Agents Consideredmentioning

confidence: 99%

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Budani

Tiboni

2020

Antioxidants

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“…This finding is in agreement with the results of our study. Youssef et al used antioxidant preparations containing vitamins A, C, and E, zinc, molybdenum, selenium, biotin, and bioflavonoids in unexplained infertility groups; these groups showed no difference in clinical pregnancy rates [21]. Despite the similar patient group, the significant increase in clinical pregnancy rates revealed in the current study may be due to the fact that CoQ10 is not only an antioxidant but also an agent that increases mitochondrial energy production.…”

Section: Discussionmentioning

confidence: 39%

“…This study was carried out on 299 patients with unexplained infertility between 21 DHA 230 mg; TAB, Turkey) for two months before ovarian stimulation. These were registered as the subject group, while 164 patients who did not take the supplement were evaluated as the control group.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing <i>in Vitro</i> Fertilization for Unexplained Infertility

Özdemir¹,

Ayas²,

Güven³

et al. 2019

OJOG

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Objective: This is a retrospective study to evaluate the effect of using the antioxidants containing coenzyme Q10 (CoQ10) and omega-3 in patients undergoing in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) for unexplained infertility. Materials Methods: A total of 299 patients undergoing IVF-ICSI for unexplained infertility at the IVF center of Ondokuz Mayıs University were studied. The subject group consisted of 135 patients who used OMEPA Q10 (Co Q10 100 mg, omega-3 600 mg, eicosapentaenoic acid 300 mg, docosahexaenoic acid 230 mg) for two months before ovarian stimulation. A group of 164 patients who did not use the supplement were evaluated as the control group. Results: The pregnancy rate of patients using antioxidants was statistically higher than that of those who did not use the supplement (p < 0.05). The pregnancy rates of patients in the two groups were 32.9% and 49.6% respectively. The pregnancy rate of patients using antioxidants was statistically higher than that of those who did not use the supplement (p < 0.05) seemed not enough. Conclusion: We concluded that using antioxidants that contain Co Q10 and omega-3 in patients undergoing IVF-ICSI for unexplained infertility increased the clinical pregnancy rate. We recommend using antioxidants that contain Co Q10 and omega-3 in infertile patients.

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“…On the other hand, there are some trials that failed to report this beneficial effect of oral antioxidant supplementation in the treatment of female infertility. In a study by Youssef et al [36], oral antioxidants in the form of a combination of multivitamins and minerals did not improve oocyte quality and pregnancy rates in women with unexplained infertility undergoing IVF/ICSI treatment. The lack of significant differences between the study and control groups could be explained by a lack of follicular fluid antioxidants during in vitro fertilization that may disturb the oxidant-antioxidant balance, rendering the culture media less protected against oxidation.…”

Section: Discussionmentioning

confidence: 92%

Two Spontaneous Pregnancies after Treatment with Ovocyplus<sup>TM</sup> among an Infertile Patient with Two Failed IVF: A Case Report

Kacem¹,

Mustapha²,

Sallem³

et al. 2015

ARSci

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The role of oxidative stress in female reproduction is becoming increasingly important, as recent evidence suggests that it has been implicated in the pathology of infertility of both known and idiopathic origin. Although its efficacy has yet to be well established, supplementation with antioxidants is a new tool being developed in the therapeutic armamentarium for female-factor infertility. We present a case of a spontaneous viable pregnancy in a 37-year-old patient with a history of two consequent In Vitro Fertilization (IVF) failures, occurring after a 5-month antioxidant treatment. This report suggests that oral antioxidants supplementation in female patients may provide an alternative or adjunct to conventional fertility therapies and improve their chances of becoming pregnant.

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Oral antioxidants supplementation for women with unexplained infertility undergoing ICSI/IVF: Randomized controlled trial

Abstract: Oral antioxidants in the form of a combination of multivitamins and minerals (amino acid chelated) did not improve oocyte quality and pregnancy rates in women with unexplained infertility undergoing IVF/ICSI treatment.

Cited by 29 publications

References 20 publications

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing <i>in Vitro</i> Fertilization for Unexplained Infertility

Two Spontaneous Pregnancies after Treatment with Ovocyplus<sup>TM</sup> among an Infertile Patient with Two Failed IVF: A Case Report

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Oral antioxidants supplementation for women with unexplained infertility undergoing ICSI/IVF: Randomized controlled trial

Abstract: Oral antioxidants in the form of a combination of multivitamins and minerals (amino acid chelated) did not improve oocyte quality and pregnancy rates in women with unexplained infertility undergoing IVF/ICSI treatment.

Cited by 29 publications

References 20 publications

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing &lt;i&gt;in Vitro&lt;/i&gt; Fertilization for Unexplained Infertility

Two Spontaneous Pregnancies after Treatment with Ovocyplus&lt;sup&gt;TM&lt;/sup&gt; among an Infertile Patient with Two Failed IVF: A Case Report

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Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing <i>in Vitro</i> Fertilization for Unexplained Infertility

Two Spontaneous Pregnancies after Treatment with Ovocyplus<sup>TM</sup> among an Infertile Patient with Two Failed IVF: A Case Report