Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration

Keenan, Tiarnán D.L.; Agrón, Elvira; Keane, Pearse A.; Domalpally, Amitha; Chew, Emily Y.

doi:10.1016/j.ophtha.2024.07.014

Ophthalmology

2024

DOI: 10.1016/j.ophtha.2024.07.014

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Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration

Tiarnán D.L. Keenan,

Elvira Agrón,

Pearse A. Keane

et al.

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Natural Products in the Treatment of Retinopathy of Prematurity: Exploring Therapeutic Potentials

Heo,

Ryu

2024

IJMS

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Retinopathy of prematurity (ROP) is a vascular disorder affecting the retinas of preterm infants. This condition arises when preterm infants in incubators are exposed to high oxygen levels, leading to oxidative stress, inflammatory responses, and a downregulation of vascular endothelial growth factors, which causes the loss of retinal microvascular capillaries. Upon returning to room air, the upregulation of vascular growth factors results in abnormal vascular growth of retinal endothelial cells. Without appropriate intervention, ROP can progress to blindness. The prevalence of ROP has risen, making it a significant cause of childhood blindness. Current treatments, such as laser therapy and various pharmacologic approaches, are limited by their potential for severe adverse effects. Therefore, a deeper understanding of ROP’s pathophysiology and the development of innovative treatments are imperative. Natural products from plants, fungi, bacteria, and marine organisms have shown promise in treating various diseases and have gained attention in ROP research due to their minimal side effects and wide-ranging beneficial properties. This review discusses the roles and mechanisms of natural products that hold potential as therapeutic agents in ROP management.

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Natural Products in the Treatment of Retinopathy of Prematurity: Exploring Therapeutic Potentials

Heo,

Ryu

2024

IJMS

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Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration

Cited by 1 publication

References 64 publications

Natural Products in the Treatment of Retinopathy of Prematurity: Exploring Therapeutic Potentials

Natural Products in the Treatment of Retinopathy of Prematurity: Exploring Therapeutic Potentials

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