Oral antidiabetic therapy in a large Italian sample: drug supply and compliance for different therapeutic regimens

Gaddi, Antonio Vittorino; Benedetto, Danilo; Capello, Fabio; Pietro, Caterina Di; Cinconze, E.; Rossi, Elisa; Sando, Valeria De; Cevenini, Monica; D'Alò, G

doi:10.1016/j.puhe.2013.05.009

Cited by 16 publications

(25 citation statements)

References 24 publications

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“…Similar frequencies for the prescription of metformin are also found in the USA, at ~ 55% . Metformin is prescribed much more frequently in France and Canada at ~ 79%, and also in other European Countries at 60–70% . Compared with other European countries and Canada, however, metformin is prescribed significantly less often in Germany.…”

Section: Resultssupporting

confidence: 59%

“…The frequency of prescription of drugs without proof of benefit is < 10% in most countries, except for Greece and the USA, where the prescription of thiazolidinediones is ~ 17% and 30%, respectively .…”

Section: Resultsmentioning

confidence: 99%

“…Accordingly, most guidelines for the management of Type 2 diabetes recommend metformin as the drug of first choice [32][33][34]. Correspondingly, the most frequently prescribed antihyperglycaemic drug in most countries is metformin [22,[35][36][37][38][39][40][41]. This is also reflected in the AOK data, which showed that metformin was prescribed most frequently.…”

Section: Discussionmentioning

confidence: 99%

“…The frequency of the prescription of sulfonylureas is in Germany and also in Sweden~20% [22]. This is significantly lower than in other European countries, as well as in the USA and Canada, with frequencies of 30-45% [22,[35][36][37][38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

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Healthcare utilization of people with Type 2 diabetes in Germany: an analysis based on health insurance data

et al. 2015

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Section: Resultssupporting

confidence: 59%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Healthcare utilization of people with Type 2 diabetes in Germany: an analysis based on health insurance data

et al. 2015

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“…Disease CVD (n = 11) [35,45,48,49,52,[58][59][60][61][62][63] HT (n = 31) [5,33,[38][39][40][41][42]46,53,55,56,[64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83]] DMII (n = 10) [31,32,36,43,44,51,54,[84][85][86]] HIV (n = 14) [30,…”

Section: Results (Number Of Studies With a Certain Feature) Referencesmentioning

confidence: 99%

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

et al. 2020

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Many patients, especially those with a high pill burden and multiple chronic illnesses, are less adherent to medication. In medication treatments utilizing polypills, this problem might be diminished since multiple drugs are fused into one formulation and, therefore, the therapy regimen is simplified. This systematic review summarized evidence to assess the effect of polypills on medication adherence. The following databases were searched for articles published between 1 January 2000, and 14 May 2019: PubMed, Web of Science, Cochrane Library, and Scopus. Medication adherence was the only outcome assessed, regardless of the method of measuring it. Sixty-seven original peer-reviewed articles were selected. Adherence to polypill regimens was significantly higher in 56 articles (84%) compared to multiple pill regimens. This finding was also supported by the results of 13 out of 17 selected previously published systematic reviews and meta-analyses dealing with this topic. Adherence can be improved through the formulation of polypills, which is probably why the interest in researching them is growing. There are many polypills on the market, but the adherence studies so far focused mainly on a small range of medical conditions.

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The accuracy of self‐reported drug ingestion histories in emergency department patients

Monte

Heard

Hoppe

et al. 2014

The Journal of Clinical Pharma

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Inaccuracies in self-reports may lead to duplication of therapy, failure to appreciate non-compliance leading to exacerbation of chronic medical conditions, or inaccurate research conclusions. Our objective is to determine the accuracy of self-reported drug ingestion histories in patients presenting to an urban academic emergency department (ED). We conducted a prospective cohort study in ED patients presenting for pain or nausea. We obtained a structured drug ingestion history including all prescription drugs, OTC drugs, and illicit drugs for the 48 hours prior to ED presentation. We obtained urine comprehensive drug screens (CDS) and determined self-report/CDS concordance. Fifty-five patients were enrolled. Self-reported drug ingestion histories were poor in these patients; only 17 (30.9%) of histories were concordant with the CDS. For the individual drug classes, prescription drug-CDS was concordant in 32 (58.2%), OTC-CDS was concordant in 33 (60%), and illicit drug-CDS was concordant in 45 (81.8%) of subjects. No demographic factors predicted an accurate self-reported drug history. Sixteen patients had drugs detected by CDS that were unreported by history. Nine of these 16 included an unreported opioid. In conclusion, self-reported drug ingestion histories are often inaccurate and resources are needed to confirm compliance and ensure unreported drugs are not overlooked.

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Oral antidiabetic therapy in a large Italian sample: drug supply and compliance for different therapeutic regimens

Cited by 16 publications

References 24 publications

Healthcare utilization of people with Type 2 diabetes in Germany: an analysis based on health insurance data

Healthcare utilization of people with Type 2 diabetes in Germany: an analysis based on health insurance data

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

The accuracy of self‐reported drug ingestion histories in emergency department patients

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