2022
DOI: 10.1093/eurheartj/ehac111
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Oral anticoagulants in patients with atrial fibrillation at low stroke risk: a multicentre observational study

Abstract: Aims There is currently no consensus on whether atrial fibrillation (AF) patients at low risk for stroke (one non-sex-related CHA2DS2-VASc point) should be treated with an oral anticoagulant. Methods and results We conducted a multi-country cohort study in Sweden, Denmark, Norway, and Scotland. In total, 59 076 patients diagnosed with AF at low stroke risk were included. We assessed the rates of stroke or major bleeding durin… Show more

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Cited by 29 publications
(24 citation statements)
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“…However, the present study indicates that atrial fibrillation was not associated with sICH risk. In recent years, this may be related to clinicians’ more scientific and rational oral anticoagulant use under the guidance of guidelines and RCTs [43, 44]. This study did not consider oral anticoagulants and antiplatelet therapy as the risk factors for sICH, which may partially support this hypothesis.…”
Section: Discussionmentioning
confidence: 91%
“…However, the present study indicates that atrial fibrillation was not associated with sICH risk. In recent years, this may be related to clinicians’ more scientific and rational oral anticoagulant use under the guidance of guidelines and RCTs [43, 44]. This study did not consider oral anticoagulants and antiplatelet therapy as the risk factors for sICH, which may partially support this hypothesis.…”
Section: Discussionmentioning
confidence: 91%
“…26 A recent large, multi-country, cohort study of 59 076 patients at low stroke risk (hypertension in 23%) and with newly diagnosed AF suggests that nonvitamin K antagonist oral anticoagulant treatment may be associated with a 28% lower rate for stroke without increasing intracranial bleeding compared with no anticoagulant treatment. 27 Whether or not oral anticoagulation in patients at low stroke risk is clinically meaningful and cost-effective is a matter for debate, 28 and should be tested through a randomized controlled trial.…”
Section: Early Transition To Management Of Atrial Fibrillation In Hyp...mentioning
confidence: 99%
“…It seems that oral anticoagulation conferred a lower risk of TEE in AF patients who had a single nonsex-based risk factor for stroke, 11 but such results have not been confirmed by a Korean registry that found higher TEE in a large low-risk cohort. 12 The default position is to offer stroke prevention through anticoagulant drugs unless patients are at minimal risk (Table 1).…”
Section: Introductionmentioning
confidence: 96%
“…It seems that oral anticoagulation conferred a lower risk of TEE in AF patients who had a single nonsex-based risk factor for stroke, 11 but such results have not been confirmed by a Korean registry that found higher TEE in a large low-risk cohort 12 …”
Section: Introductionmentioning
confidence: 99%
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