2016
DOI: 10.3382/ps/pev341
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Oral antibodies to human intestinal alkaline phosphatase reduce dietary phytate phosphate bioavailability in the presence of dietary 1α-hydroxycholecalciferol

Abstract: While it is well established that active vitamin D treatment increases dietary phytate phosphate utilization, the mechanism by which intestinal alkaline phosphatase (IAP) participates in phytate phosphate use is less clear. The ability of human IAP (hIAP) oral antibodies to prevent dietary phytate phosphate utilization in the presence of 1α-hydroxycholecalciferol (1α-(OH) D3) in a chick model was investigated. hIAP specific chicken immunoglobulin Y (IgY) antibodies were generated by inoculating laying hens wit… Show more

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Cited by 13 publications
(6 citation statements)
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“…Bobeck et al used IgY against the human intestinal alkaline phosphatase (hIAP) to assess the influence of IAP on increased bioavailability of phytate phosphate in the presence of 1α-dihydroxycholecalciferol (vitamin D3) in chickens. Anti-hIAP IgY was ingested by chickens and reduced the absorption of phytate phosphate, which suggests that although it performed less adequately than sevelamer chorhydrate, already used for the same purpose, anti-hIAP IgY can be optimized for the prevention of phytate phosphate toxicity induced by the consumption of the active form of vitamin D [101].…”
Section: Prophylaxis Of Toxicitymentioning
confidence: 99%
“…Bobeck et al used IgY against the human intestinal alkaline phosphatase (hIAP) to assess the influence of IAP on increased bioavailability of phytate phosphate in the presence of 1α-dihydroxycholecalciferol (vitamin D3) in chickens. Anti-hIAP IgY was ingested by chickens and reduced the absorption of phytate phosphate, which suggests that although it performed less adequately than sevelamer chorhydrate, already used for the same purpose, anti-hIAP IgY can be optimized for the prevention of phytate phosphate toxicity induced by the consumption of the active form of vitamin D [101].…”
Section: Prophylaxis Of Toxicitymentioning
confidence: 99%
“…In animals, salmonellosis (Yokoyama et al, 1998;Gurtler et al, 2004), colibacillosis (Ikemori et al, 1992;Yokoyama et al, 1992;Li et al, 2009;Mahdavi et al, 2010;Germine et al, 2011), rotaviral diarrhea (Vega et al, 2011), infectious bursal disease (Yousif et al, 2006), porcine epidemic diarrhea (Kweon et al, 2000), coccidiosis (Lee et al, 2009a,b), clostridial infections (Pizarro-Guajardo et al,. 2017), vibriosis (Hirai et al, 2010), staphylococcosis (Leclaire et al, 2002), streptocococcosis (Zhou et al, 2003), white spot syndrome (Lu et al, 2009), flu (Tsukamoto et al, 2011), hantaviral pneumonia (Haese et al, 2015), tetanus (Selim et al, 2015), snake poisoning (Paul et al, 2007;Meenatchisundaram et al, 2008a,b;de Almeida et al, 2008;Lee et al, 2016), rabies (Motoi et al, 2005) and phytate phosphate toxicity (Bobeck et al, 2016) were studied.…”
Section: Immunoprophylactic Role Of Igy In Human and Animal Diseasesmentioning
confidence: 99%
“…Broiler chickens have shown some ability to adapt to diets low in P and Ca by increasing the efficiency of digestion and/or absorption of these nutrients ( Yan et al, 2005 ). Two physiological mechanisms could allow the bird to meet its P requirement when its diet is low in P. First, given the presence of brush border phosphatases in the intestinal tract of the bird ( Maenz and Classen, 1998 ; Bobeck et al, 2016 ) and the rich supply of phytate P in most poultry diets, perhaps a physiological need for P leads to greater expression of these phosphatases with subsequent greater digestion of P from phytate ( Onyango et al, 2006 ; Rodehutscord et al, 2022 ). Secondly, there is evidence that the sodium-dependent active P transporters (e.g.…”
Section: Introductionmentioning
confidence: 99%