Oral antibiotics perturbation on gut microbiota after prostate biopsy

Li, Joseph Kai Man; Wang, Lynn Lin; Lau, Becky Su Yan; Tse, Ryan Tsz‐Hei; Cheng, Carol Ka Lo; Leung, Steven Chi Ho; Wong, Christine Yim Ping; Tsui, Stephen Kwok Wing; Teoh, Jeremy Yuen Chun; Chiu, Peter Ka Fung; Ng, Chi Fai

doi:10.3389/fcimb.2022.959903

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…68 Interestingly, research on single-dose antibiotic prophylaxis performed before transperineal biopsies showed that it could lead to changes in gut microbiota composition. 69 According to EAU guidelines, prostatic biopsy should be performed using a transperineal approach due to the lower risk of infective complications. Routine surgical disinfection of perineal skin should be performed.…”

Section: Prostate Biopsymentioning

confidence: 99%

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Antibiotic prophylaxis in urologic interventions: Who, when, where?

Marino,

Rossi,

Murri

et al. 2024

Urologia

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Background: Periprocedural prophylaxis in medicine encompasses the set of measures (physical, chemical, and pharmacological) used to reduce the risk of infection. Antibiotic prophylaxis (AP) refers to the administration of a short-term regimen of antibiotics shortly before a medical procedure to reduce the risk of infectious complications that can result from diagnostic and therapeutic interventions. The outspreading growth of multidrug-resistant bacterial species and changes in the bacterial local ecosystem have impeded the development of a unique scheme of AP in urology. Objectives: To review the literature and current guidelines regarding AP for urological diagnostic and therapeutic procedures, and to define agents, timing, and occasions when administering pharmacological prophylaxis. Secondly, according to current literature, to open new scenarios where AP can be useful or useless. Results: Major gaps in evidence still exist in this field. AP appears useful in many invasive procedures and some sub-populations at risk of infectious complications. AP is not routinely recommended for urodynamic exams, diagnostic cystoscopy, and extracorporeal shock-wave lithotripsy. The available data regarding the use of AP during the transperineal prostate biopsy are still unclear; conversely, in the case of the transrectal approach AP is mandatory. AP is still considered the gold standard for the prevention of postoperative infective complications in the case of ureteroscopy, percutaneous nephrolithotomy, endoscopic resection of bladder tumor, endoscopic resection of the prostate, and prosthetic or major surgery. Conclusion: The review highlights the complexity of determining the appropriate candidates for AP, emphasizing the importance of considering patient-specific factors such as comorbidities, immunocompetence, and the nature of the urologic intervention. The evidence suggests that a one-size-fits-all approach may not be suitable, and a tailored strategy based on the specific procedure and patient characteristics is essential.

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Section: Prostate Biopsymentioning

confidence: 99%

“…Interestingly, research on single-dose antibiotic prophylaxis performed before transperineal biopsies showed that it could lead to changes in gut microbiota composition. 69…”

Section: Diagnostic Proceduresmentioning

confidence: 99%

Antibiotic prophylaxis in urologic interventions: Who, when, where?

Marino,

Rossi,

Murri

et al. 2024

Urologia

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Moving the Needle: Antibiotic Prophylaxis Is No Longer Required in the Era of Transperineal Prostate Biopsy

Chiu¹,

Kasivisvanathan²,

Gandaglia³

2023

European Urology

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Gut microbiome: a novel preventive and therapeutic target for prostatic disease

Cao,

Zhang,

Wang

et al. 2024

Front. Cell. Infect. Microbiol.

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The human gut microbiome (GM) impacts various physiological processes and can lead to pathological conditions and even carcinogenesis if homeostasis is disrupted. Recent studies have indicated a connection between the GM and prostatic disease. However, the underlying mechanisms are still unclear. This review aims to provide a summary of the existing information regarding the connection between the GM and various prostatic conditions such as chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), benign prostatic hyperplasia (BPH), and prostate cancer (PCa). Furthermore, the review aims to identify possible pathogenic mechanisms and suggest potential ways of targeting GM to prevent and treat prostatic disease. Due to the complexity of the mechanism between GM and prostatic diseases, additional research is required to comprehend the association between the two. This will lead to more effective treatment options for prostatic disease.

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Oral antibiotics perturbation on gut microbiota after prostate biopsy

Cited by 4 publications

References 51 publications

Antibiotic prophylaxis in urologic interventions: Who, when, where?

Antibiotic prophylaxis in urologic interventions: Who, when, where?

Moving the Needle: Antibiotic Prophylaxis Is No Longer Required in the Era of Transperineal Prostate Biopsy

Gut microbiome: a novel preventive and therapeutic target for prostatic disease

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