1989
DOI: 10.1128/aac.33.12.2063
|View full text |Cite
|
Sign up to set email alerts
|

Oral and parenteral therapy with saperconazole (R 66905) of invasive aspergillosis in normal and immunocompromised animals

Abstract: Saperconazole (R 66905) is a broad-spectrum antifungal triazole with potent in vitro activity against Aspergillus spp. A total of 279 strains were tested in brain heart infusion broth. Development of the Aspergillus spp. was completely inhibited at 0.1 and 1 microgram of saperconazole per ml for 80.3 and 99.6% of the strains, respectively. Normal and immunocompromised guinea pigs were infected intravenously with Aspergillus fumigatus and treated orally, intravenously, or intraperitoneally with saperconazole or… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

1
24
0

Year Published

1992
1992
2010
2010

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 44 publications
(25 citation statements)
references
References 15 publications
1
24
0
Order By: Relevance
“…On the other hand, pigeons inoculated with A. fumigatus spores intravenously showed similar results as the models for Group 1, HBSS in right thoracic air sac; Group 2, HBSS in right lung; Group 3, dexamethasone; Group 4, A. fumigatus in right thoracic air sac; Group 5, A. fumigatus in right lung; Group 6, A. fumigatus in right thoracic air sac after dexamethasone injections; Group 7, A. fumigatus in right lung after dexamethasone injections; Group 8, A. fumigatus in trachea after dexamethasone injections. acute aspergillosis in this study (Van Cutsem et al, 1989;Elmubarak & Fadlelmula, 1991). Discrepancy with literature can be caused by species-dependent susceptibility for A. fumigatus infections and/or variability of pathogenicity of the A. fumigatus isolates used in the different studies (Peden & Rhoades, 1992).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…On the other hand, pigeons inoculated with A. fumigatus spores intravenously showed similar results as the models for Group 1, HBSS in right thoracic air sac; Group 2, HBSS in right lung; Group 3, dexamethasone; Group 4, A. fumigatus in right thoracic air sac; Group 5, A. fumigatus in right lung; Group 6, A. fumigatus in right thoracic air sac after dexamethasone injections; Group 7, A. fumigatus in right lung after dexamethasone injections; Group 8, A. fumigatus in trachea after dexamethasone injections. acute aspergillosis in this study (Van Cutsem et al, 1989;Elmubarak & Fadlelmula, 1991). Discrepancy with literature can be caused by species-dependent susceptibility for A. fumigatus infections and/or variability of pathogenicity of the A. fumigatus isolates used in the different studies (Peden & Rhoades, 1992).…”
Section: Discussionmentioning
confidence: 99%
“…The more acute model may allow the detection of strain-dependent differences of virulence. Although experimental infections with A. fumigatus have been carried out in quails, starlings, pigeons, turkeys and chickens using different inoculation routes (intravenously, intratracheally, in the abdominal/thoracic air sac, intrapulmonary and using aerosol), there is an absolute necessity to compare these routes in one bird species in order to select the appropriate model (Chute & O'Meara, 1958;Wright et al, 1960;Richard et al, 1973Richard et al, , 1981Richard & Thurston, 1983;Dyar et al, 1984;Van Cutsem et al, 1989;Julian & Goryo, 1990;Elmubarak & Fadlelmula, 1991;Peden & Rhoades, 1992;Perelman, 1993;Kunkle & Rimler, 1996;Kunkle et al, 1999;Atasever & Gü mü ssoy, 2004;Gü mü ssoy et al, 2004;Femenia et al, 2007). It was therefore the aim of this study to select an acute and a chronic aspergillosis model in pigeons.…”
Section: Introductionmentioning
confidence: 99%
“…There are a number of drugs that interfere with the absorption of itraconazole, among which are agents such as antacids that are also commonly used in neutropenic patients (32,90). In one study on prophylactic itraconazole in 72 neutropenic patients, suspected or proven fungal infections, including IPA, occurred significantly more often in patients with inadequate serum itraconazole levels (<250 ng/ml) (10 (7,35,86,97 (40).…”
Section: Systemic Prophylaxis With Azole Antifungal Agentsmentioning
confidence: 99%
“…Saperconazole has been shown to have activity in a guinea pig model and in a murine model of aspergillosis (8,18), but its limited activity in another murine model (15) could be related to the low levels in serum achieved with orally administered drug in that model. Absorption of related triazole compounds, such as ketoconazole and itraconazole, has been reported to be erratic in some immunosuppressed hosts (5,6), so that adequate delivery of drug via oral administration is likely essential for successful therapy.…”
mentioning
confidence: 99%