Oral and Parenteral Administration of Prostigmin and Its Analogues in Myasthenia Gravis

Laurent, L. P. E.; Walker, M.B.

doi:10.1016/s0140-6736(01)21035-6

Cited by 11 publications

(1 citation statement)

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“…Eventually, she and Laurent reported that oral Prostigmin could be given in large doses without untoward effects. 24 Miss C's response to Prostigmin was so dramatic and rapid that some in the audience questioned if the patient had a functional disorder. London neurologist Dr Douglas McAlpine later clarifi ed in a letter to the Lancet that the patient presented by Mary Walker clearly had myasthenia, as he had previously cared for the patient and her disease had in fact progressed despite treatment with ephedrine.…”

Section: Pioneering Treatment For Myasthenia Gravismentioning

confidence: 99%

The Mary Walker Effect: Mary Broadfoot Walker

McCarter

Burkholder

Klaas

et al. 2019

Journal of the Royal College of Physicians of Edinburgh

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Mary Broadfoot Walker (1888-1974) was the first to demonstrate the ‘Mary Walker effect’ describing the weakness of other muscle groups following release of the arteriovenous occlusion of an unrelated exercising muscle group in patients with myasthenia gravis, which led to the search for a circulating causative agent for myasthenia gravis. She was the first to clearly demonstrate that strength temporarily improved in patients with myasthenia gravis with physostigmine or Prostigmin (neostigmine). This dramatic treatment response has been erroneously termed the ‘Mary Walker effect'. Further, she noted hypokalaemia during attacks of weakness in familial periodic paralysis, pioneering treatment with potassium chloride. Although Mary Walker practiced in a nonacademic setting and trained at a time when women were not allowed to train alongside men, she was the first to convincingly demonstrate three life-changing treatments in the field of neuromuscular medicine, a feat that few physicians of any era can claim.

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Section: Pioneering Treatment For Myasthenia Gravismentioning

confidence: 99%