Oral and oropharyngeal cancers in North India

Abstract

TuNIOURS of oral and oropharyngeal regions are the commonest miialignant tumours in North India. A number of studies (Khanolkar, 1944(Khanolkar, , 1951 Paymaster. 1956;Wahi et al., 1958) have brought out the close relationship of these tumours to environmental factors. The nature and the mode of use of the offending agents which are thought to be responsible for cancer in these regions vary from place to place. Likewise the anatomical location of tumours and their clinicopathological features are apt to be different. The purpose of this paper is to present the salient clinical and pathological features of these tumours as seen in the northern part of India. specially in the state of Uttar Pradesh. MATERIAL AND METHODSDuring the years covered by this study Bross (1958).Ridits are based on the observed distribution of response variable for a specified set of individuals. Ridits present a new application of an old idea (the probabilitv transformation) and are closely related to distribution-free method based on ranks. Ridits indicate the degree of a particular class by number. The average ridit has probability interpretation-it is an estimate of the chance that 27

Search for an adenovirus etiology of human oral and pharyngeal tumors

“…Many precise accounts of the association of use of tobacco in one form or another and the incidence of oral and pharyngeal tumors are available (Wahi et al, 1965). These reports also include patients who had never used tobacco but still developed tumors a t similar sites to those who were habituated to tobacco.…”

“…This raises the question whether some of the human tumors may have an adenovirus etiology. Oral and pharyngeal tumors which make up 35 to 40% of all reported malignancies in males in India (Tuyns and Hirayama, 1966;Wahi et al, 1965) are suitable and attractive for investigation of an adenovirus etiology. Although this report is essentially negative (Rangan et al, 1967) in the search for evidence of adenovirus etiology, the data may assist others in the search.…”

Overview of Oral Cancer

“…Primary squamous cell carcinomas arising in the soft palate are uncommon, accounting for 2 percent of overall oral cancer in reverse-smoking areas (Ramulu et al, 1973), but only 0.4 percent in non-reverse smoking areas (Wahi et al, 1965). However, reports of later studies by Mashberg and Meyers (1976) indicated a greater frequency of lesions primarily arising from the soft palate than is ordinarily documented with the "late" symptomatic lesions.…”

Pathology of Carcinoma of the Hard Palate

“…Clinical staging was done according to the criteria of Wahi et at. [17] in stage I-IV. The macroscopic aspect was examined in respect of microinvasive carcinoma, plaque-like flat ulcera tive lesions, exophytic growth, verrucous type, and perforation.…”