Oral and Jaw Lymphoma in an Iranian Population

Mohtasham, Nooshin; Babakoohi, Shahab; Sarraf-Yadzy, Maryam; Sadr, Bardia; Ghaffarzadegan, Kamran; Shiva, Atena; Abbaszadeh, Hamid; Kamyab‐Hesari, Kambiz; Mortazavi, Seyed Majed; Nassiri-Kashani, Mansour

doi:10.1097/scs.0b013e31820f7d07

Cited by 9 publications

(16 citation statements)

References 9 publications

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“…Gnepp reported that DLBL was the most common type of lymphoma of Waldeyer’s tonsillar ring followed by peripheral T cell lymphoma, MALT (mucosa-associated lymphoid tissue) lymphoma and FL in a decreasing order of prevalence ( 14 ) In our study, MALT and peripheral T cell lymphoma were each seen in one case and follicular type was found in 20 cases. In a study by Mohtasham et al ( 15 ), on 36 cases of oral lymphomas, DLBL (41.1%), low-grade B cell lymphoma (35.2%), peripheral T cell lymphoma (11.7%), Burkitt’s lymphoma (5.8%) and HL (5.8%) had the highest frequency in decreasing order. Although Mohtasham et al ( 15 ) did not use the accredited WHO classification for lymphomas, DLBL was the most common subtype, which is in line with the results of the current study.…”

Section: Discussionmentioning

confidence: 97%

“…In a study by Mohtasham et al ( 15 ), on 36 cases of oral lymphomas, DLBL (41.1%), low-grade B cell lymphoma (35.2%), peripheral T cell lymphoma (11.7%), Burkitt’s lymphoma (5.8%) and HL (5.8%) had the highest frequency in decreasing order. Although Mohtasham et al ( 15 ) did not use the accredited WHO classification for lymphomas, DLBL was the most common subtype, which is in line with the results of the current study. In addition, Kemp et al ( 1 ) reported that DLBL comprised 58% and B cell lymphoma comprised 98% of cases.…”

Section: Discussionmentioning

confidence: 97%

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Oral Lymphoma Prevalence in Iranian Population: A Multicenter Retrospective Study

Akbari

Bastani²,

Mokhtari

et al. 2015

Iran J Cancer Prev

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Background:Oral lymphoma is the second most common malignancy of the head and neck region after malignant epithelial tumors.Objectives:Considering the lack of a multicenter study on the frequency of oral lymphoma in Iran, this study aimed to assess the relative frequency of oral lymphomas in Iran during a 6-year period.Materials and Methods:This multicenter, retrospective, cross-sectional study was conducted in two phases. In the first phase, cases of oral lymphoma registered in the cancer research center (CRC) of Shahid Beheshti university of medical sciences were extracted. The patient records and pathology reports of these patients were retrieved from the archives and age, sex and microscopic type site of the lesions were evaluated.Results:Oral lymphoma accounts for 1% of head and neck malignancies and 8% of all lymphomas. From 2003 to 2008, a total of 437 new cases of oral lymphomas had been registered in the CRC. Diffuse large B-cell lymphoma was found to be the most common form of oral lymphoma in the 6-year period with 240 (54.9%) registered cases. The majority of detected cases were in the 6th and 7th decades of life with a male to female ratio of 1:84. Tonsils were the most common site of occurrence of lymphoma in the oral cavity (77.8%).Conclusions:The age of onset, site of involvement, sex of patients, and histopathological subtype of oral lymphomas in the Iranian population were found to be similar to those of most other countries.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Oral Lymphoma Prevalence in Iranian Population: A Multicenter Retrospective Study

Akbari

Bastani²,

Mokhtari

et al. 2015

Iran J Cancer Prev

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“…Usually non-Hodgkin lymphomas of the head and neck area occur more often in men, with approximately 55-77% of cases 12 , 13 , 15 , 16 . In the present study only 45% of all patients were men, so that women were slightly more often affected.…”

Section: Discussionmentioning

confidence: 99%

Malignant Lymphomas in the Head and Neck Region - a Retrospective, Single-Center Study over 41 Years

Walter¹,

Ziebart²,

Sagheb³

et al. 2015

Int. J. Med. Sci.

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Objectives: Non-Hodgkin lymphomas are malignant neoplastic proliferations of the immune system that can manifest as nodal or extranodal lymphomas. The aim of this study was to retrospectively investigate the site of occurrence of lymphomas in the head and neck area and to analyze the typical symptoms of patients who presented at an oral and maxillofacial surgical department.Material and Methods: All patient files from1971 until 2012 from an Oral and Maxillofacial Surgery of a University were analyzed for the diagnosis non-Hodgkin lymphoma. Epidemiologic data and data regarding the localization of the malignant lymphoma were evaluated.Results: 62 patients, 34 women and 28 men with a non-Hodgkin lymphoma in the head and neck area were treated in the 41 years analyzed. In 87% of the cases the lymphoma belonged to B-cell and in 12% to the T-cell lineage. The average age at the time of diagnosis was 67 years for women (n=34) and 56 years for men. With 22 patients each, the non-Hodgkin lymphoma was localized in either the soft tissues or osseous structures. In the remaining 18 cases, multiple structures were affected. In 33 patients no accompanying nodal manifestation was noticed. In 33 cases the lymphoma was located in the oral cavity. The most common symptoms were swelling (97%), pain (40%) and the existence of an ulcer (11%).Conclusion: In the present study more than 50% of the lymphomas were located in the oral cavity. Due to the unspecific symptoms, a histopathological verification of the diagnosis is crucial.

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“…Mashhad has a substantial Turkmen community, which is East Asian in contrast to the mainly Indo-European community in Teheran. The relative period prevalence in Teheran was 0.74 [41], the highest of all case series in Table 1, whereas that of Mashhad was 0.20 [40], almost the lowest of all case series. The difference in the maxilla/mandible ratio between these two case series tended to significant (FET = 0.080).…”

Section: Discussionmentioning

confidence: 99%

“…Ethnicity may also play a role in some of the other outliers observed in Tables 1 and 2. After the Teheran Iranians [41], the Nigerians [35] had the second highest relative period prevalence of 0.60.…”

Section: Discussionmentioning

confidence: 99%

Extranodal lymphoma arising within the maxillary alveolus: a systematic review

MacDonald

Lim

2017

Oral Radiol

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ObjectivesExtranodal lymphomas affecting the head and neck infrequently arise within the jaw bones. Although clinical examination and conventional radiography may initially suffice for such lesions arising within the mandible, those arising within the maxillary alveolus generally require cross-sectional imaging because of the complex anatomy of this region. This study was performed to determine the prevalence, demographic characteristics, and clinical presentations of these lesions and the imaging modalities used for their diagnosis.Study designA systematic review (SR) on case series and another SR on case reports were performed to investigate the demographic, clinical, and radiological features of extranodal lymphomas arising within the maxillary alveolus.ResultsMost case series were derived from just four nations, whereas the case reports were derived from a wider range of ethnicities. The more detailed case reports significantly reported at least one imaging modality. Most patients were aware of their lesions for nearly 2 months before presentation. The most frequent symptom was swelling. Most case reports included a provisional diagnosis, the most frequent of which was dental infection followed by squamous cell carcinoma.DiscussionExtranodal lymphomas arising within the maxillary alveolus were sufficiently frequent in four communities to be reported in two or more case series, and the occasional single case report indicated that such lesions are more widespread globally. Although the SR on case series revealed differences in the relative period prevalence and maxillary/mandibular ratio, the SR on case reports revealed details of the clinical presentation and imaging modalities used.

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Oral and Jaw Lymphoma in an Iranian Population

Abstract: The epidemiology of different types of oral lymphoma in a sample of Iranian population was not similar with other populations of the world. Immunohistochemistry and molecular methods are required to prove the diagnosis in addition to typing of lymphoma.

Cited by 9 publications

References 9 publications

Oral Lymphoma Prevalence in Iranian Population: A Multicenter Retrospective Study

Oral Lymphoma Prevalence in Iranian Population: A Multicenter Retrospective Study

Malignant Lymphomas in the Head and Neck Region - a Retrospective, Single-Center Study over 41 Years

Extranodal lymphoma arising within the maxillary alveolus: a systematic review

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