Oral and Intramuscular Treatment Options for Early Postpartum Endometritis in Low-Resource Settings

Abstract

This review provides suggestions for oral, intramuscular, and combined antimicrobial regimens that may warrant additional study. Experimental trials should consider clinical effectiveness, safety and side effects profiles, and feasibility of community-based treatment.

Chlorhexidine–Alcohol Compared with Povidone–Iodine Preoperative Skin Antisepsis for Cesarean Delivery: A Systematic Review and Meta-Analysis

“…9 Endometritis was excluded as it is considered an organ space infection separate from wound infection and is thought to be an ascending and polymicrobial infection not generally attributable to skin pathogens. [9][10][11] Subgroup analyses of studies including superficial versus deep wound infection and povidoneiodine solutions with versus without alcohol were conducted for the primary outcome of overall surgical site infection. Secondary outcomes included wound seroma, hematoma, skin separation, and skin reaction.…”

Diagnostic methods to determine microbiology of postpartum endometritis in South Asia: laboratory methods protocol used in the Postpartum Sepsis Study: a prospective cohort study

“…After informed written consent, clinical diagnostic specimens, including urine, blood, and endometrial, were collected from these confirmed puerperal sepsis cases. All women with puerperal sepsis were prescribed recommended first-line antibiotics (amoxicillin-clavulanate or oral clindamycin with intramuscular gentamicin) based on a recent metaanalysis [4], unless otherwise indicated by the laboratory results.…”

Das frühe Wochenbett – Physiologie und Pathologie

“…Wenn sich innerhalb von 48 h die klinische Symptomatik nicht bessert, sollte zusätzlich das Anaerobierspektrum durch Metronidazol plus Gentamicin (3 × 1,5 mg/ kgKG i. v./Tag oder Einzeldosis: 5 mg/kgKG i. v./Tag abgedeckt werden [17].…”

“…Durch die Endotoxinproduktion, insbesondere der Streptokokken der Gruppe A, kommt es zu einer ausgedehnten Gewebezerstörung; dies kann damit zu foudroyanten lebensbedrohlichen Verlaufsformen durch das Multiorganversagen führen. Ein rascher Therapiebeginn mit breiter Antibiose in Zusammenarbeit mit Intensivmedizinern ist daher therapieentscheidend [17]. Hierbei sollten die Therapieempfehlungen der Paul-Ehrlich-Gesellschaft berücksichtigt werden [17].…”

“…Ein rascher Therapiebeginn mit breiter Antibiose in Zusammenarbeit mit Intensivmedizinern ist daher therapieentscheidend [17]. Hierbei sollten die Therapieempfehlungen der Paul-Ehrlich-Gesellschaft berücksichtigt werden [17].…”