Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims

Gondivkar, Shailesh; Gadbail, Amol R.; Sarode, Sachin C.; Hedaoo, Amol; Dasgupta, Subhrajit; Sharma, Balkrishna; Sharma, Arindam; Yuwanati, Monal; Patil, Shankargouda; Gaikwad, Rahul

doi:10.1016/j.jobcr.2021.01.004

Cited by 10 publications

(13 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, our study shows that OHRQoL is poor also among long-term HNC survivors who have not received radiotherapy. This is in line with a previous study, which assessed OHRQoL 1 and 6 months after different types of HNC therapy [ 13 ].…”

Section: Discussionsupporting

confidence: 92%

“…Most published studies use quality of life assessment tools that are specifically developed for HNC cancer patients such as the EORTC QLQ-C30 together with the QLQ-H&N35 [ 9 , 10 ]. Several studies have also assessed the more specific oral health related quality of life (OHRQoL) of HNC patients, and find that it is severely affected during treatment and the first year after treatment [ 11 – 13 ]. However, few studies have assessed the OHRQoL in long-term HNC survivors and compared it to a general population, to see whether it reverts towards the general population with time.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study

2022

View full text Add to dashboard Cite

Background Both the incidence and survival rate of head and neck cancer (HNC) is increasing, making quality of life of HNC survivors an important issue. Methods In this cross-sectional study we compared the oral health related quality of life (OHRQoL) of long-term HNC survivors to that of a general population cohort from the seventh survey of the Tromsø study with the Oral Impact on Daily Performances questionnaire. Comparisons were done with frequency analyses and cross tabulation. We also assessed OHRQoL’s association to sociodemographic and oral health related variables in both cohorts as well as with cancer related variables in the HNC cohort with regression analyses. Results The HNC survivors had four times the risk of reporting problems with daily performances compared with the general population cohort. The ability to eat and enjoy food was most frequently affected in both cohorts. Moderate-poor self-rated dental health and general health as well as high frequency of dental visits were significantly associated with poorer OHRQoL. To have a history of oral or pharyngeal cancer was associated with more problems than having a history of laryngeal cancer. Conclusions Our study shows that HNC treatment is associated with a strong and lasting impairment of OHRQoL, highlighting the need to find less toxic, yet effective ways to treat the disease, and to provide easy access to expert dental care at all stages of the disease to minimize morbidity. Given the widespread side effects of cancer treatment, a multidisciplinary approach might be required to improve the OHRQoL of HNC survivors.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study

2022

View full text Add to dashboard Cite

show abstract

“…There is a tremendous amount of literature to support that oral symptoms become higher after RT even though the tools used were not specifically designed to measure OHRQOL among cancer patients [ 28 – 30 ]. Many studies have evaluated OHRQOL in patients with oral cancer using the Oral Health Impact Profile-14 and found a negative impact on OHRQOL after RT [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Oral health related quality of life of oral cancer patients treated with radiotherapy alone or with chemotherapy in a tertiary referral centre in Sri Lanka

et al. 2023

View full text Add to dashboard Cite

Background Oral cancer is the number one cancer among males in Sri Lanka. Radiotherapy is a common treatment modality for oral cancer, but this can affect oral health related quality of life (OHRQOL). This study assessed the OHRQOL and its changes from baseline to the last week of radiotherapy and three months post radiotherapy among oral cancer patients who received this treatment alone or with chemotherapy. Methods A prospective longitudinal study was conducted among 90 oral cancer patients awaiting for radiotherapy alone or with chemotherapy. The modified Sinhala version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Oral Health Module (EORTC QLQ-OH15) was used to gather data related to OHRQOL before radiotherapy. Socio-demographic and clinical data were also recorded. The same cohort of patients were followed up and assessed their OHRQOL during the last week of radiotherapy and three months post radiotherapy. The Modified EORTC QLQ-OH15 assesses the OHRQOL under three domains namely ‘Eating problem’, ‘Gum and speech problem’ and ‘Soreness’, and one item named as ‘Teeth’. Results The majority of the sample (88%) was males. The anterior two-thirds of the tongue (40%) and buccal mucosa (22%) were the most common sites. The median scores of ‘Eating problem’ domain at baseline, last week of radiotherapy and three months post radiotherapy were 20 (IQR = 6.7–33.3), 100 (IQR = 86.9–100.0) and 66.7 (IQR = 46.7–93.3) respectively. ‘Gum and speech problem’ was higher during last week of radiotherapy (median, 50.0, IQR, 25.0-58.3) than three months post radiotherapy (median, 8.3, IQR, 0.0-33.3). The changes of OHRQOL between the time frames were statistically significant (p < 0.05). Baseline OHRQOL in relation to ‘Gum and speech problem’ domain and ‘Teeth’ item was identified as an influential factor for OHRQOL during last week of radiotherapy. Conclusion The OHRQOL of oral cancer patients who received radiotherapy alone or with chemotherapy had deteriorated from the baseline level to the last week of radiotherapy but then improved at three months post radiotherapy. The OHRQOL however did not return to the baseline level three months post radiotherapy. OHRQOL during the last week of radiotherapy was influenced by the OHRQOL at baseline, civil status and sites of metastasis.

show abstract

“…There is a tremendous amount of literature to support that oral symptoms become higher after RT even though the tools used were not speci cally designed to measure OHRQOL among cancer patients (20,21,22). Many studies have evaluated OHRQOL in patients with oral cancer using the Oral Health Impact Pro le-14 and found a negative impact on OHRQOL after RT (23).…”

Section: Discussionmentioning

confidence: 99%

Oral health related quality of life of oral cancer patients treated with radiotherapy alone or with chemotherapy in a tertiary referral centre in Sri Lanka

Kosgallana¹,

Jayasekara

Abeysinghe

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Oral cancer is the number one cancer in males in Sri Lanka. Radiotherapy is a common treatment modality for oral cancer, but this can affect oral health related quality of life (OHRQOL). This study assessed the OHRQOL and its changes from baseline to the last week of radiotherapy and three months post radiotherapy among oral cancer patients who received this treatment alone or with chemotherapy. Methods A prospective longitudinal study was conducted among 90 oral cancer patients waiting for radiotherapy alone or with chemotherapy. The modified Sinhala version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Oral Health Module (EORTC QLQ-OH15) was used to gather data related to OHRQOL before radiotherapy, during the last week of radiotherapy and three months after completion of radiotherapy. Socio-demographic and clinical data were also recorded. Results The majority of the sample (88%) were males. The anterior two-thirds of the tongue (40%) and buccal mucosa (22%) were the most common sites of oral cancer. The median scores of ‘Eating problem’ domain at baseline, last week of radiotherapy and three months after radiotherapy were 20 (IQR = 6.7–33.3), 100 (IQR = 86.9–100.0) and 66.7 (IQR = 46.7–93.3) respectively. ‘Gum and speech problem’ was higher during last week of radiotherapy (median, 50.0, IQR, 25.0-58.3) than three months post radiotherapy (median, 8.3, IQR, 0.0-33.3). The changes in the ‘Eating problem’, ‘Gum and speech problem’ and ‘Soreness’ domains and the item ‘Teeth’ between the time frames were statistically significant. Conclusion The OHRQOL of oral cancer patients who received radiotherapy alone or with chemotherapy had deteriorated from the baseline level to the last week of radiotherapy but then improved at three months post radiotherapy. The OHRQOL however did not return to the baseline level three months post RT.

show abstract

Oral and general health-related quality of life in oral squamous cell carcinoma patients- comparative analysis of different treatment regims

Cited by 10 publications

References 29 publications

Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study

Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study

Oral health related quality of life of oral cancer patients treated with radiotherapy alone or with chemotherapy in a tertiary referral centre in Sri Lanka

Oral health related quality of life of oral cancer patients treated with radiotherapy alone or with chemotherapy in a tertiary referral centre in Sri Lanka

Contact Info

Product

Resources

About