Oral and Dental Considerations in Pediatric Leukemic Patient

Padmini, C P; Bai, Kaihong

doi:10.1155/2014/895721

Cited by 32 publications

(55 citation statements)

References 52 publications

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“…Palifermin is one of the newest agents to be proposed to prevent the development of mucositis . It has been suspected that the decreased proliferative ability of oral epithelial cells has a role in the pathogenesis of mucositis; hence, several growth factors that can increase epithelial cell proliferation have been investigated for OM management . Palifermin is a recombinant keratinocyte growth factor (KGF) that is used to treat patients suffering from hematological malignancies undergoing myeloablative therapy, which is commonly associated with a high incidence of severe mucositis.…”

Section: Discussionmentioning

confidence: 99%

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Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta‐analysis

Mazhari

Shirazi

Shabzendehdar

2018

Pediatric Blood & Cancer

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Background One of the most common complications of cancer chemotherapy is oral mucositis (OM). OM affects more than 75% of patients undergoing chemotherapy and represents a significant burden to patients and caregivers. We performed a systematic review and metaanalysis of published studies to investigate the effects of agents and techniques in reducing OM. Procedure This systematic review investigated, critically appraised, and rated the evidence on agents used to manage OM in children undergoing cancer therapy. A comprehensive search of the relevant literature was performed from January 2006 to December 2017. MEDLINE, Scopus, the Cochrane Database of Systematic Reviews, EMBASE, and the Web of Science were searched. Nine eligible studies were identified. Using randomeffects models, standardized mean difference was estimated between treated and control groups across all studies. The Cochran test and the I2 index were performed for heterogeneity between studies. The significance level was set at P = 0.05. Results Palifermin reduced the incidence (OR = 4.131, P = 0.000), duration (St diff mean = 0.803, P = 0.000), and severity (St diff mean = 0.637, P = 0.000) of OM in pediatric cancer patients significantly. However, the laser did not show significant efficacy in decreasing the incidence rate of OM (OR = 2.870, P = 0.364). Conclusion This review provided a comprehensive examination of available options for children who have OM. The results support the possibility of a positive effect of palifermin on reducing OM in children receiving cancer therapy.

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Section: Discussionmentioning

confidence: 99%

“…LLLT hastens wound healing in mucositis by increasing mitochondrial ATP production, local release of growth factors, increasing proliferation of fibroblasts, detoxifying oxygen free radicals or reducing the formation of these free radicals, and increasing microcirculation in mucosa …”

Section: Discussionmentioning

confidence: 99%

Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta‐analysis

Mazhari

Shirazi

Shabzendehdar

2018

Pediatric Blood & Cancer

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“… Frequent topical fluoride applications in the form of mouthwash or toothpaste and pit and fissure sealants on the molars prevent dental caries. The dentist can apply concentrated topical fluorides if necessary . The dental team should give dietary advice and inform the patient which type of foods should be avoided when possible: restriction of sticky food and dietary sucrose, elimination of food that irritate the oral mucosa. Sodium bicarbonate or saline mouthwash could be considered to reduce the frequency of oral mucositis and oral pathogens in children with ALL . The use of chlorhexidine rinses is controversial .…”

Section: Dental Management Of All Childrenmentioning

confidence: 99%

Oral complications and dental care in children with acute lymphoblastic leukaemia

Valera

Noirrit‐Esclassan

Pasquet

et al. 2014

J Oral Pathology Medicine

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Acute leukaemia is the most common type of childhood cancer, the acute lymphoblastic type accounting for the majority of cases. Children affected by leukaemia receive various forms of treatments including chemotherapeutic agents and stem cell transplants. Leukaemia and its treatment can directly or indirectly affect oral health and further dental treatments. The oral complications include mucositis, opportunistic infections, gingival inflammation and bleeding, xerostomia and carious lesions. An additional consideration in children is the impact of the treatments on the developing dentition and on orofacial growth. The aim of this review is to describe the oral complications in children with acute lymphoblastic leukaemia and the methods of prevention and management before, during and after the cancer treatment.

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“…Another cause of mouth dryness is associated with chemotherapy and radiotherapy of the head and neck in patients with neoplasias. For instance, children in chemotherapy for leukemia treatment [34]. The severity of these treatments induce xerostomia and the problems associated to low salivary flux [35].…”

Section: Risk Factors Associated To Periodontal Diseasementioning

confidence: 99%

Periodontal Disease: General Aspects from Biofilm to the Immune Response Driven by Periodontal Pathogens

Degasperi¹,

Etchegaray²,

Marcelino³

et al. 2018

AiM

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Periodontal disease is of inflammatory origin and affects the dental support tissues. The initial phase is characterized by the accumulation of biofilm, which is a predisposing factor for several oral pathologies. The combination of extrinsic factors such as lack of hygiene, smoking and diet, and intrinsic factors such as genetics, and major changes in the immune response associated with immune escape mechanisms of biofilm constituents are crucial to the development and progression of the disease, which when untreated entails local irreversible consequences that can lead to systemic changes. In this brief review, we describe general aspects of periodontal disease, its risk factors and ways of preventing the disease. In particular, we discuss some of the mechanisms of immune response to periodontal pathogens, as well as the escape mechanisms of these microorganisms.

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Oral and Dental Considerations in Pediatric Leukemic Patient

Cited by 32 publications

References 52 publications

Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta‐analysis

Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta‐analysis

Oral complications and dental care in children with acute lymphoblastic leukaemia

Periodontal Disease: General Aspects from Biofilm to the Immune Response Driven by Periodontal Pathogens

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