Oral Aggregations of Microbes

Krasse, Bo

doi:10.1177/00220345630420016201

Cited by 20 publications

(7 citation statements)

References 23 publications

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“…Dental plaque was first defined by James Leon Williams in 1897, who described a ‘gelatinous accumulation of bacteria, attached to the tooth surface and related to the development of dental caries’ (46). Before that, in 1846, Finicius (183) had already reported on the consistent presence of clumps of microorganisms associated with dental caries. The notion of an extracellular matrix of polysaccharides produced by plaque bacteria, which ‘may favor the crowding and grouping of microorganisms in the plaque…’ (183) has also permeated the dental literature since the 1960s.…”

Section: Lesson Learned: Periodontal Diseases Are Biofilm Infectionsmentioning

confidence: 99%

“…Before that, in 1846, Finicius (183) had already reported on the consistent presence of clumps of microorganisms associated with dental caries. The notion of an extracellular matrix of polysaccharides produced by plaque bacteria, which ‘may favor the crowding and grouping of microorganisms in the plaque…’ (183) has also permeated the dental literature since the 1960s. An updated description of dental plaque from 1973 already contained all elements of Costerton’s biofilm definition (207):…”

Section: Lesson Learned: Periodontal Diseases Are Biofilm Infectionsmentioning

confidence: 99%

See 1 more Smart Citation

Lessons learned and unlearned in periodontal microbiology

Teles¹,

Teles²,

Frias-Lopez³

et al. 2013

Periodontology 2000

294

292

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Periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or below the gingival margin and progress largely as a result of the inflammation initiated by specific subgingival species. In the past few decades, efforts to understand the microbiota of periodontal diseases have led to an exponential increase in information about biofilms associated with periodontal health and disease. In fact, the oral microbiota is one of the best characterized microbiomes that colonize the human body. Despite this increased knowledge, one has to ask if our fundamental concepts of the etiology and pathogenesis of periodontal diseases have really changed. In this chapter we will review how our comprehension of the structure and function of the subgingival microbiota evolved over the years in search of lessons learned and unlearned in periodontal microbiology. More specifically, this review focuses on: 1) how the data obtained through molecular techniques has impacted our knowledge of the etiology of periodontal infections; 2) the potential role of viruses in the etiopathogenesis of periodontal diseases; 3) how concepts of microbial ecology have expanded our understanding of host microbial interactions that might lead to periodontal diseases; 4) the role of inflammation in the pathogenesis of periodontal diseases; and 5) the impact of these evolving concepts on treatment and preventive approaches to periodontal infections. We will conclude by reviewing how novel systems biology approaches promise to unravel new details of the pathogenesis of periodontal diseases and, hopefully, lead to a better understanding of periodontal disease mechanisms.

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Section: Lesson Learned: Periodontal Diseases Are Biofilm Infectionsmentioning

confidence: 99%

Section: Lesson Learned: Periodontal Diseases Are Biofilm Infectionsmentioning

confidence: 99%

Lessons learned and unlearned in periodontal microbiology

Teles¹,

Teles²,

Frias-Lopez³

et al. 2013

Periodontology 2000

294

292

View full text Add to dashboard Cite

show abstract

“…This concept has been extensively re-state. Baer and Newton (1960) described a type viewed (Rosebury 1955, MacDonald 1960, of naturally occurring periodontal disease in MacDonald, Gibbons and Socransky 1960, germfree mice which was characterized by WHO 1961, Conference 1962, Friedman 1962, bone loss and apical proliferation of the epi- Cohen 1963, Krasse 1963inflammation was not a 1963inflammation was not a , Schcrp 1964. Also, systemic factors have component of the disease process, and no been studied in order to determine whether or conspicuous differences between germfree and not they play a role in periodontal disease.…”

Section: Tbe Pathogenesis Of Periodontal Disease Ismentioning

confidence: 99%

The influence of bacteria and irritation in the initiation of periodontal disease in germfree and conventional rats

Rovin

Costich

Gordon

1966

J of Periodontal Research

219

138

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Within the conditions of the experimental design, this study has provided laboratory evidence that microorganisms were necessary for the occurrence of inflammatory periodontal disease. Furthermore, this investigation has shown that the presence of both local irritation and microorganisms was necessary to produce periodontal inflammation. However, neither factor alone was capable of producing the inflammation. The results of this study have shown that a type of dental calculus may be formed in the absence of microorganisms. However, the same results have demonstrated that the presence of microorganisms greatly facilitates the formation of calculus. The presence of polymorphonuclear leukocytes in the gingival crevices and tissues could not be explained on the basis of bacteria and/or irritation. It was postulated that these cells are a normal component of the gingival tissues of these animals and that their presence does not constitute a pathologic process. The findings of the present study were considered with those of other studies. From this comparison it was suggested that differences in animal species and strains should be considered when evaluations and extrapolations of experimental results are made.

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“…The elderly are more likely to have a discoloured tongue surface because of changes in diet, an inability to cope with oral hygiene methods, and a decrease in salivary flow 1 . The papillary structure of the dorsum of the tongue forms a unique ecological site that provides a large surface area favouring the accumulation of oral debris and microorganisms 2 . Although the dorsum of the tongue seems to harbour one of the most complex microbiological niches in human ecology, our knowledge of the role of tongue flora in the elderly is extremely limited.…”

Section: Introductionmentioning

confidence: 99%