Oral Administration of Vitamin B 12 in Pernicious Tapeworm Anemia

Antianemic Activity of Dried Fish Tapeworm

“…In consequence of the above-mentioned findings the question arises: How does the tapeworm exert its noxious influence on the interaction between extrinsic and intrinsic factor? As indicated in previous papers (3,4,5 ) , various explanations might be suggested. Assuming that a reaction between these substances, for instance of an enzymatic character, takes place in the intestine, it might be thought that the tapeworm interferes somehow with this reaction by means of a toxic influence.…”

Castle's Test (with Vitamin B12 and Normal Gastric Juice) in the Ileum in Patients with Genuine and Patients with Tapeworm Pernicious Anaemia

“…The effect of B,, without any addition of GJ has therefore been tested in tapeworm PA. Orally administered B,, alone gave either no haematological response or a remarkably good remission (5). These results are discussed in the D monograph, p. 146.…”

“…For the sake of control, oral administration of B,, ought to have preceded the instillation into the ileum in at least one experiment. On the other hand, the failure of Castle's classical test in tapeworm PA may be considered an established fact on a basis of a very large number of previous experiments (3,5 ) (Fig. 7).…”