Oral administration of the Aureobasidium pullulans-derived β-glucan effectively prevents the development of high fat diet-induced fatty liver in mice

Aoki, Shigenobu; Iwai, Atsushi; Kawata, Keiichiro; Muramatsu, Daisuke; Uchiyama, Hirofumi; Okabe, Mitsuyasu; Ikesue, Masahiro; Maeda, Naoyuki; Uede, Toshimitsu

doi:10.1038/srep10457

Cited by 22 publications

(18 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…β-glucan exhibits immune stimulatory activity, and is consumed as a supplement in many countries. Also, A. pullulans culture supernatant is believed to exhibit beneficial effects in delaying the onset of a number of diseases, and has been reported to exhibit antitumor, antiallergy and anti-infectious disease activities in mouse models [58][59][60][61][62][63][64][65][66][67][68]. An interesting review by Li et al [69] on Aureobasidium spp.…”

Section: Pullulan and Other Polysaccharidesmentioning

confidence: 99%

The Multiple and Versatile Roles of Aureobasidium pullulans in the Vitivinicultural Sector

Bozoudi

Tsaltas

2018

Fermentation

View full text Add to dashboard Cite

The saprophytic yeast-like fungus Aureobasidium pullulans has been well documented for over 60 years in the microbiological literature. It is ubiquitous in distribution, being found in a variety of environments (plant surfaces, soil, water, rock surfaces and manmade surfaces), and with a worldwide distribution from cold to warm climates and wet/humid regions to arid ones. Isolates and strains of A. pullulans produce a wide range of natural products well documented in the international literature and which have been regarded as safe for biotechnological and environmental applications. Showing antagonistic activity against plant pathogens (especially post-harvest pathogens) is one of the major applications currently in agriculture of the fungus, with nutrient and space competition, production of volatile organic compounds, and production of hydrolytic enzymes and antimicrobial compounds (antibacterial and antifungal). The fungus also shows a positive role on mycotoxin biocontrol through various modes, with the most striking being that of binding and/or absorption. A. pullulans strains have been reported to produce very useful industrial enzymes, such as β-glucosidase, amylases, cellulases, lipases, proteases, xylanases and mannanases. Pullulan (poly-α-1,6-maltotriose biopolymer) is an A. pullulans trademark product with significant properties and biotechnological applications in the food, cosmetic and pharmaceutical industries. Poly (β-l-malic acid), or PMA, which is a natural biopolyester, and liamocins, a group of produced heavy oils and siderophores, are among other valuable compounds detected that are of possible biotechnological use. The fungus also shows a potential single-cell protein source capacity with high levels of nucleic acid components and essential amino acids, but this remains to be further explored. Last but not least, the fungus has shown very good biocontrol against aerial plant pathogens. All these properties are of major interest in the vitivinicultural sector and are thoroughly reviewed under this prism, concluding on the importance that A. pullulans may have if used at both vineyard and winery levels. This extensive array of properties provides excellent tools for the viticulturist/farmer as well as for the oenologist to combat problems in the field and create a high-quality wine.

show abstract

Section: Pullulan and Other Polysaccharidesmentioning

confidence: 99%

The Multiple and Versatile Roles of Aureobasidium pullulans in the Vitivinicultural Sector

Bozoudi

Tsaltas

2018

Fermentation

View full text Add to dashboard Cite

show abstract

“…Currently, an increasing number of studies have focused on polysaccharides extracted from different Chinese medicines due to their potential pharmacological activities. Many types of polysaccharides have shown appreciable effects in the amelioration of NAFLD or diabetes, such as Lycium barbarum polysaccharide 6 , Radix Hedysari polysaccharide 7 , Aureobasidium pullulans -derived β-glucan 8 , Rehmannia glutinosa polysaccharide 9 and Ganoderma lucidum polysaccharide 10 . Specifically, these polysaccharides have demonstrated hypolipidemic/hypoglycemic effects or antioxidative properties.…”

mentioning

confidence: 99%

Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice

Wang

Cao

Wang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

This study aimed to investigate the therapeutic effects of Angelica sinensis polysaccharide (ASP), an active component derived from a water extract of Angelica sinensis, in high-fat diet (HFD)-fed BALB/c mice. The potential mechanisms underlying the activity of this compound were also considered. Specifically, serum and hepatic biochemical parameters were evaluated, and key proteins involved in the lipid/glucose metabolism were analyzed. Long-term feeding with a HFD induced severe fatty liver and hyperglycemia. Histological examination clearly showed that ASP reduced lipid accumulation in the liver and attenuated hepatic steatosis in HFD-fed mice. In addition, ASP markedly alleviated serum and liver lipid disorders and fatty liver via the upregulation of PPARγ expression and the activation of adiponectin-SIRT1-AMPK signaling. Furthermore, ASP also significantly relieved severe oxidative stress, demonstrating that ASP might attenuate nonalcoholic fatty liver disease via a "two-hit" mechanism. In addition, ASP reduced blood glucose levels and ameliorated insulin resistance via the regulation of related metabolic enzymes and by activating the PI3K/Akt pathway in HFD-fed mice. Our findings revealed that ASP might be used as an alternative dietary supplement or health care product to ameliorate metabolic syndrome in populations that consistently consume HFDs.Environmental factors, such as a high-fat diet (HFD) and a sedentary lifestyle, are the causes of the current epidemic of metabolic syndrome, which is characterized by a group of metabolic risks including hyperglycemia, hyperlipidemia, hypertension and insulin resistance 1 . Excessive exposure to a HFD is believed to play a key role in the pathogenesis of metabolic damages and has led to an increased number of individuals with nonalcoholic fatty liver disease (NAFLD) and diabetes 2,3 . NAFLD, which represents a spectrum of liver pathologies that range from simple steatosis to severe hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma, has become the most common cause of chronic liver diseases 4 . HFD-induced hyperglycemia increases the risk of development of type 2 diabetes, which is also an epidemic disease in modern society. Changes in dietary habits merit particular consideration because a HFD leads to severe hyperglycemia, metabolic damages and fatty liver. However, the modification of dietary habits and lifestyles are not readily accepted in many developed countries. Therefore, dietary supplementation or consumption of health foods could be an alternative means for the prevention of metabolic syndrome.Traditional Chinese medicines are rich sources of bioactive substances that can be used to pretreat or cure various types of human diseases 5 . Polysaccharides are polymeric carbohydrate macromolecules composed of long chains of monosaccharide units that are connected by various glycosidic linkages. Currently, an increasing number of studies have focused on polysaccharides extracted from different Chinese medicines due to their potential 1

show abstract

“…It was reported that daily doses of 3 g of oat β‐glucan could help hypercholesterolemic people reduce plasma total and low‐density lipoprotein cholesterol levels (Othman et al., 2011). In line with this finding, Shiho Aoki et al noted that the Aureobasidium pullulans‐derived β‐glucan effectively prevented the development of fatty liver induced by a high‐fat diet in mice (Aoki et al, 2015). Based on this evidence, we hypothesized that β‐glucan may be an effective functional food for NASH treatment.…”

Section: Introductionmentioning

confidence: 78%

β‐Glucan ameliorates nonalcoholic steatohepatitis induced by methionine and choline‐deficient diet in mice

Huang

Liu

et al. 2020

J. Food Biochem.

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is currently one of the most extensive chronic liver diseases worldwide and is known as a major risk factor for cardiovascular diseases (Almanza et al., 2019). Nonalcoholic steatohepatitis (NASH) is an important stage of NAFLD, which further develops into cirrhosis or hepatocellular carcinoma. NASH is typically characterized by hepatic pathology of steatosis, inflammation, and ballooning. In recent years, the prevalence of NAFLD and NASH has been constantly increasing. It

show abstract

Oral administration of the Aureobasidium pullulans-derived β-glucan effectively prevents the development of high fat diet-induced fatty liver in mice

Cited by 22 publications

References 27 publications

The Multiple and Versatile Roles of Aureobasidium pullulans in the Vitivinicultural Sector

The Multiple and Versatile Roles of Aureobasidium pullulans in the Vitivinicultural Sector

Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice

β‐Glucan ameliorates nonalcoholic steatohepatitis induced by methionine and choline‐deficient diet in mice

Contact Info

Product

Resources

About