Oral administration of natural polyphenol-loaded natural polysaccharide-cloaked lipidic nanocarriers to improve efficacy against small-cell lung cancer

Xie, Xuemei; Li, Yuan; Zhao, Dezhang; Fang, Chunshu; He, Dongyi; Yang, Qiang; Yang, Lin; Chen, Ran; Tan, Qingyuan; Zhang, Jingqing

doi:10.1016/j.nano.2020.102261

Cited by 20 publications

(40 citation statements)

References 43 publications

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“…Also, Cc@CLNs causing a decrease of the levels of the SCLC stem cell markers CD133 and ABCG2. SCLC H446 tumor-bearing mice after treatment via Cc@CLNs showed a lower tumor size and weight [66].…”

Section: Lipid-based Nanocarriersmentioning

confidence: 95%

Lung Cancer Oncotherapy through Novel Modalities: Gas Plasma and Nanoparticle Technologies

Rasouli¹,

Fallah²,

Ostrikov³

2021

Lung Cancer - Modern Multidisciplinary Management

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Cold atmospheric pressure plasma (CAP) is emerging as new healthcare technology and it has a high potential through physical and chemical effects for cancer treatment. Recently, CAP, plasma activated liquid (PAL), and nanomaterial have been significant advances in oncotherapy. Reactive oxygen-nitrogen species (RONS), electrical field, and other agents generated by CAP interact with cells and induce selective responses between the malignant and normal cells. Nanomedicine enhances therapeutic effectiveness and decreases the side effects of traditional treatments due to their target delivery and dispersion in tumor tissue. There are various nanocarriers (NCs) which based on their properties can be used for the delivery of different agents. The combination of gas plasma and nanomaterials technologies is a new multimodal treatment in cancer treatment, therefore, is expected that the conjunction of these technologies addresses many of the oncology challenges. This chapter provides a framework for current research of NC and gas plasma therapies for lung cancer. Herein, we focus on the application of gas plasmas and nanotechnology to drug and gene delivery and highlight several outcomes of its. The types and features of the mentioned therapeutics strategy as novel classes for treating lung cancer individually and synergistic were examined.

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Section: Lipid-based Nanocarriersmentioning

confidence: 95%

Lung Cancer Oncotherapy through Novel Modalities: Gas Plasma and Nanoparticle Technologies

Rasouli¹,

Fallah²,

Ostrikov³

2021

Lung Cancer - Modern Multidisciplinary Management

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“…It is used to measure Naringin and Naringin-NPs for in vitro cytotoxicity. The cells of A549 and HEL-299were plated 2×10 4 cell per well in a 96-well culture plate for the attachment followed by cultured for 24 h at 37°C. 10 µL of the MTT solution was applied to each well after incubation at 37°C for 24 hours, and the 525 nm absorbance was analyzed 2 hrs later by Eliza microplate reader (TECAN Sunrise, Switzerland).…”

Section: In Vitro Proliferation Assay By Mttmentioning

confidence: 99%

“…Lung cancer remains the leading cause of cancer-related mortality in the United States, with a quarter of all tumour deaths due to this condition in 2015. A large number of patients are commonly diagnosed with advanced non-small cell lung cancer (NSCLC) owing to its asymptomatic form, requiring intensive and precise care following diagnosis [1][2][3][4]. Combination drug treatments are being investigated, as the synergistic activity of several medications may theoretically lead to improved clinical effectiveness and decreased risk for developing drug resistance in cancer cells [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Synergic Fabrication of Naringin Molecule into Polymeric Nanoparticles for the Treatment and Nursing Care of Lung Cancer Therapy

2021

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Lung cancer is the third most common cause of death and the main factor of cancer-related deaths in both males and females in the United States to the rest of the world. Diagnosis at an important level is associated with high mortality in the population of cases. Herein, we present a very easy and costeffective method that incorporates drugs reconstruction, tumor-speci c targeting supramolecular nanoassembly, and therapeutically to overcome the different challenges raised by the distribution of the pharmaceutical potential anticancer drug Naringin. On covalent conjugations of hydrophobic linoleic acid by hydroxyl group, the Naringin prodrugs were skilled in impulsively nanoassembly into extremely steady nanoparticles size (~100 nm). Electron microscopic techniques have veri ed the newly synthesized morphology of Naringin-NPs. The anticancer properties of Naringin and Naringin-NPs against A549 and HEL-299 (lung carcinoma) cancer cell lines have been evaluated after successful synthesis. Other research, such as dual staining acridine orange/ethidium bromide, Hoechst 33344 and ow cytometry study on the apoptosis mechanisms have shown that proliferation in lung cancer cells is associated with apoptosis. Compared to Naringin, Naringin-NPs demonstrate excellent biocompatibility, this study clari ed the Naringin-NPs as a healthy and positive lung cancer treatment and care chemotherapeutics technique and deserve further clinical evaluations. Highlights 1. Fabrication of Naringin on covalent conjugations of linoleic acid by impulsively nanoassembly (Naringin-NPs). 2. The in vitro cytotoxicity activity shows Naringin-NPs induced apoptosis in human lung cancer cells. 3. The morphological examinations and cell death of Naringin-NPs have studied AO/EB and nuclear staining methods. 4. The cell death of Naringin-NPs was con rmed by ow cytometry analysis. 5. Naringin-NPs shows excellent hemocompatibility pro les.

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“…[1][2][3] The low solubility of the drugs ultimately results in a series of problems in the clinical work, such as poor absorption, low bioavailability, dose escalation and unsatisfactory clinical outcome, especially in oral drug administration which is still the most common and preferable delivery route for most various therapeutic agents with the best patient compliance and fewest safety concerns. [4][5][6][7][8] For example, ibuprofen is a welldocumented long-term nonsteroidal anti-inflammatory drug, mainly functions to reduce fever, inflammation and pain. Due to its safety and effectiveness, it is widely used in both adults and children, and is popular as an OTC analgesic-antipyretic drug.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Several effective strategies (such as co-solvents, micronizations, nanosizing, salifications and complexations) and formulations (such as aqueous/organic gels, nanoemulsions, polymeric nanoparticles, liposomes, vesicles and micelles) have been developed to overcome these obstacles. 1,5,6,[11][12][13][14][15][16] Different from the traditional "soft" organic drug delivery systems mentioned above, silica-containing materials with inorganic "rigid" matrices possess thermal/chemical stability, mechanical strength, physiologically inertness and are a prime asset to protect the guest molecules inside. 17,18 Furthermore, mesoporous silica nanoparticles (MSNs, the pore size range of 2 nm-50 nm) with large surface area and pore volume have integrated the advantages of nanostructured materials and silica-based fabrications, and proved to be excellent candidates to serve as hosting systems in the field of drug delivery.…”

Section: Introductionmentioning

confidence: 99%

<p>Biomimetic Synthesis and Evaluation of Interconnected Bimodal Mesostructured MSF@Poly(Ethyleneimine)s for Improved Drug Loading and Oral Adsorption of the Poorly Water-Soluble Drug, Ibuprofen</p>

Wei¹,

Wang²,

Guo³

et al. 2020

IJN

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The aim of this study was to improve the oral bioavailability and antiinflammatory activity of the poorly soluble drug ibuprofen (IBU) by employing a new kind of poly(ethyleneimine)s (PEIs)-based mesocellular siliceous foam (MSF) called B-BMSF@PEI as drug carrier. Methods: B-BMSF@PEI was biomimetically synthesized by using PEIs as templates, catalysts and scaffolds under ambient conditions, and the structural characteristics, including size, morphology, mesoscopic structure and pore properties, were estimated by TEM, SEM, FTIR and N 2 desorption/adsorption measurement. Then, IBU was incorporated into B-BMSF@PEI at the drug:carrier weight ratio of 1:1. The structural features of IBU before and after drug loading were systemically characterized. IBU and B-BMSF@PEI were then subject to in vitro drug release study and wettability analysis. Finally, in vivo pharmacokinetics and anti-inflammatory pharmacodynamics studies were carried out to evaluate the efficacy of B-BMSF@PEI on improving the oral adsorption of IBU. Results: The results demonstrated that B-BMSF@PEI was a meso-meso porous silica material with foam appearance. It consisted of uniform spherical cells (40 nm) with interconnected pore networks. IBU can be successfully loaded into B-BMSF@PEI with high efficiency (as high as 39.53%), and crystal IBU was effectively converted to an amorphous state during this process. Benefiting from the great architectures of B-BMSF@PEI, IBU/ B-BMSF@PEI performed good wetting property and significantly improved the dissolution rate in both simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Notably, IBU exhibited very satisfactory relative bioavailability (681.4%) and anti-inflammatory effects (the inhibition rates were between the ranges of 113.5% to 1504.3%). Conclusion: B-BMSF@PEI with bimodal mesoporous system and interconnected nanopores was obtained owing to the dynamic self-assembly functions of PEIs. It had superiority in drug loading and could improve the oral adsorption of ibuprofen to a satisfactory level.

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Oral administration of natural polyphenol-loaded natural polysaccharide-cloaked lipidic nanocarriers to improve efficacy against small-cell lung cancer

Cited by 20 publications

References 43 publications

Lung Cancer Oncotherapy through Novel Modalities: Gas Plasma and Nanoparticle Technologies

Lung Cancer Oncotherapy through Novel Modalities: Gas Plasma and Nanoparticle Technologies

Synergic Fabrication of Naringin Molecule into Polymeric Nanoparticles for the Treatment and Nursing Care of Lung Cancer Therapy

<p>Biomimetic Synthesis and Evaluation of Interconnected Bimodal Mesostructured MSF@Poly(Ethyleneimine)s for Improved Drug Loading and Oral Adsorption of the Poorly Water-Soluble Drug, Ibuprofen</p>

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