Oral Administration of<i>Lactobacillus plantarum</i>299v Reduces Cortisol Levels in Human Saliva during Examination Induced Stress: A Randomized, Double-Blind Controlled Trial

Andersson, Hannah; Tullberg, Cecilia; Ahrné, Siv; Hamberg, Kristina; Ahrén, Irini Lazou; Molin, Göran; Sonesson, Mikael; Håkansson, Åsa

doi:10.1155/2016/8469018

Cited by 54 publications

(45 citation statements)

References 29 publications

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“…Therefore, there is some indication that evening cortisol directly correlates with stress-associated disorders. Some studies have found an impact of probiotics on the cortisol response in stressed participants ( Chong et al, 2019 ), in particular in the response to exam stress ( Sawada et al, 2017 ; Kato-Kataoka et al, 2016 ; Andersson et al, 2016 ; Takada et al, 2016 ). Manipulation of the gut microbiota can therefore alter the neuroendocrine stress response through the HPA axis.…”

Section: Discussionmentioning

confidence: 99%

Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study)

Patterson

Griffin

Ibarra

et al. 2020

Neurobiology of Stress

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Chronic stress is a risk-factor for the development of mood and stress-related disorders. Clinical evidence indicates that probiotics can influence the stress response and mood. The Sisu study investigated whether Lacticaseibacillus paracasei Lpc-37® (Lpc-37®) could modulate stress, mood and well-being. Prior to a two-week run-in period, 120 healthy adults (18-45 y) were stratified for sex and chronic stress and randomized to either 1.75 × 10 10 colony forming units (CFU) of Lpc-37 or placebo (1:1) per day for 5 weeks. The primary objective was the effect of Lpc-37 on heart rate (HR) in response to the Trier Social Stress Test (TSST). Secondary objectives were assessed by biomarkers and self-report scales over the study. The primary hypothesis was not met in either the Intention-to-Treat (ITT) or Per Protocol (PP) population, but Lpc-37 reduced the increase in HR in participants with low chronic stress (LCS) and increased HR in participants with high chronic stress (HCS) during the TSST. Supporting significant efficacy in the PP population (n = 113), Lpc-37 reduced perceived stress following intervention. More significant effects were identified within the subgroups where Lpc-37 reduced exhaustion during the TSST and normalized cortisol levels at 8pm in participants with LCS, reduced perceived stress also in females, and increased perceived health and sleep-related recovery in participants with HCS. Adverse events (AEs) were similar between groups, there were no severe AEs, and vital signs remained unchanged. Overall, Lpc-37 reduced perceived stress compared to placebo. Other beneficial effects within biomarkers related to stress indicate that the effects of Lpc-37 may be differentially dependent on sex and chronic stress. (ClinicalTrials.gov: NCT03494725 ).

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Section: Discussionmentioning

confidence: 99%

Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study)

Patterson

Griffin

Ibarra

et al. 2020

Neurobiology of Stress

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“…The findings of predominantly beneficial effects of probiotics in rodents are matched by some positive effects of different probiotic strains in humans. For instance, in a randomized, double-blind, placebo-controlled study, Lactobacillus plantarum 299v was administered to 41 students with an upcoming exam and associated with decreased corticosterone levels after 10 days [ 86 ]. Similarly, a probiotic formulation consisting of L. helveticus R0052 and B. longum R0175 (which had been effective in mice), decreased median urinary free cortisol levels and psychological distress, when given to 26 healthy volunteers for 30 days in a double-blind, controlled, randomized, parallel study [ 87 ].…”

Section: Pro- and Prebiotics As Mostly Beneficial Modulators Of The Nmentioning

confidence: 99%

Gut Microbiota and the Neuroendocrine System

2018

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The microbial ecosystem that inhabits the gastrointestinal tract of all mammals—the gut microbiota—has been in a symbiotic relationship with its hosts over many millennia. Thanks to modern technology, the myriad of functions that are controlled or modulated by the gut microbiota are beginning to unfold. One of the systems that is emerging to closely interact with the gut microbiota is the body’s major neuroendocrine system that controls various body processes in response to stress, the hypothalamic–pituitary–adrenal (HPA) axis. This interaction is of pivotal importance; as various disorders of the microbiota–gut–brain axis are associated with dysregulation of the HPA axis. The present contribution describes the bidirectional communication between the gut microbiota and the HPA axis and delineates the potential underlying mechanisms. In this regard, it is important to note that the communication between the gut microbiota and the HPA axis is closely interrelated with other systems, such as the immune system, the intestinal barrier and blood–brain barrier, microbial metabolites, and gut hormones, as well as the sensory and autonomic nervous systems. These communication pathways will be exemplified through preclinical models of early life stress, beneficial roles of probiotics and prebiotics, evidence from germ-free mice, and antibiotic-induced modulation of the gut microbiota.Electronic supplementary materialThe online version of this article (10.1007/s13311-017-0600-5) contains supplementary material, which is available to authorized users.

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“…Moreover, a connection has been established between the digestive tract and stress [291, 292]. Several studies that supplemented healthy young college students during exam preparation with probiotics ( L. plantarum 299v and L. casei Shirota) reported attenuation of cortisol compared to a control group [293–295]. However, in an eight-week crossover design, 29 healthy male volunteers who supplemented with L. rhamnosus exhibited little difference in stress-related measures, HPA axis response, inflammation, or cognitive performance in comparison to placebo [296].…”

Section: Introductionmentioning

confidence: 99%

International Society of Sports Nutrition Position Stand: Probiotics

Jäger¹,

Mohr

Carpenter³

et al. 2019

Journal of the International Society of Sports Nutrition

166

197

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Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of probiotic supplementation to optimize the health, performance, and recovery of athletes. Based on the current available literature, the conclusions of the ISSN are as follows: Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host (FAO/WHO).Probiotic administration has been linked to a multitude of health benefits, with gut and immune health being the most researched applications.Despite the existence of shared, core mechanisms for probiotic function, health benefits of probiotics are strain- and dose-dependent.Athletes have varying gut microbiota compositions that appear to reflect the activity level of the host in comparison to sedentary people, with the differences linked primarily to the volume of exercise and amount of protein consumption. Whether differences in gut microbiota composition affect probiotic efficacy is unknown.The main function of the gut is to digest food and absorb nutrients. In athletic populations, certain probiotics strains can increase absorption of key nutrients such as amino acids from protein, and affect the pharmacology and physiological properties of multiple food components.Immune depression in athletes worsens with excessive training load, psychological stress, disturbed sleep, and environmental extremes, all of which can contribute to an increased risk of respiratory tract infections. In certain situations, including exposure to crowds, foreign travel and poor hygiene at home, and training or competition venues, athletes’ exposure to pathogens may be elevated leading to increased rates of infections. Approximately 70% of the immune system is located in the gut and probiotic supplementation has been shown to promote a healthy immune response. In an athletic population, specific probiotic strains can reduce the number of episodes, severity and duration of upper respiratory tract infections.Intense, prolonged exercise, especially in the heat, has been shown to increase gut permeability which potentially can result in systemic toxemia. Specific probiotic strains can improve the integrity of the gut-barrier function in athletes.Administration of selected anti-inflammatory probiotic strains have been linked to improved recovery from muscle-damaging exercise.The minimal effective dose and method of administration (potency per serving, single vs. split dose, delivery form) of a specific probiotic strain depends on validation studies for this particular strain. Products that contain probiotics must include the genus, species, and strain of each live microorganism on its label as well as the total estimated quantity of each probiotic strain at the end of the product’s shelf life, as measured by colony forming units (CFU) or live cells.Preclinical and early human research has shown potential probiotic benefits relevant to an athletic population that include improved body composition and lea...

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Oral Administration ofLactobacillus plantarum299v Reduces Cortisol Levels in Human Saliva during Examination Induced Stress: A Randomized, Double-Blind Controlled Trial

Cited by 54 publications

References 29 publications

Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study)

Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study)

Gut Microbiota and the Neuroendocrine System

International Society of Sports Nutrition Position Stand: Probiotics

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