Oral administration of <i>Grifola frondosa</i> polysaccharides improves memory impairment in aged rats via antioxidant action

Chen, Zhaoxia; Tang, Yanan; Liu, Along; Jin, Xiaobao; Zhu, Jianxun; Lu, Xuemei

doi:10.1002/mnfr.201700313

Cited by 33 publications

(18 citation statements)

References 40 publications

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“…Grifola frondosa polysaccharide-N (GFP-N) also demonstrated hypoglycemic effects in diabetic mouse livers [81]. GFP administration also significantly improved memory impairment in aged rats via antioxidant action, thus can be a good dietary supplement for brain aging [80].…”

Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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Macrofungi production and economic value have been increasing globally. The demand for macrofungi has expanded rapidly owing to their popularity among consumers, pleasant taste, and unique flavors. The presence of high quality proteins, polysaccharides, unsaturated fatty acids, minerals, triterpene sterols, and secondary metabolites makes macrofungi an important commodity. Macrofungi are well known for their ability to protect from or cure various health problems, such as immunodeficiency, cancer, inflammation, hypertension, hyperlipidemia, hypercholesterolemia, and obesity. Many studies have demonstrated their medicinal properties, supported by both in vivo and in vitro experimental studies, as well as clinical trials. Numerous bioactive compounds isolated from mushrooms, such as polysaccharides, proteins, fats, phenolic compounds, and vitamins, possess strong bioactivities. Consequently, they can be considered as an important source of nutraceuticals. Numerous edible mushrooms have been studied for their bioactivities, but only a few species have made it to the market. Many species remain to be explored. The converging trends and popularity of eastern herbal medicines, natural/organic food product preference, gut-healthy products, and positive outlook towards sports nutrition are supporting the growth in the medicinal mushroom market. The consumption of medicinal mushrooms as functional food or dietary supplement is expected to markedly increase in the future. The global medicinal mushroom market size is projected to increase by USD 13.88 billion from 2018 to 2022. The global market values of promising bioactive compounds, such as lentinan and lovastatin, are also expected to rise. With such a market growth, mushroom nutraceuticals hold to be very promising in the years to come.

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Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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“…With an increase in the global population and extension of lifespan, aging is becoming one of the most important public health issues (Chen et al, 2017). Aging is a known major risk factor in many human diseases such as cancer, idiopathic Parkinson's disease, type I and II diabetes, cardiovascular disease, and metabolic syndrome (Barzilai et al, 2012;Dillin et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Improving effect of a probiotic mixture on memory and learning abilities in d-galactose–treated aging mice

Hsieh

Wang

et al. 2019

Journal of Dairy Science

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The aim of this study was to evaluate the antiaging effect of a probiotic mixture using an in vivo mouse model in which aging was induced with d-galactose. Results of the Morris water maze test indicated that long-term administration of the probiotic mixture improved memory and learning abilities and ameliorated the apoptosis pattern in the hippocampus of aging mice treated with d-galactose. An antioxidation experiment indicated that administration of the probiotic mixture could restore activities of the antioxidant enzymes superoxide dismutase and catalase and inhibit the production of malondialdehyde. The antioxidant-related proteins nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were upregulated in liver after treatment of d-galactose-treated aging mice with probiotics. Finally, the probiotic treatment did affect the production of short-chain fatty acids in d-galactose-treated aging mice. Our results highlighted a possible antioxidative effect triggered by short-chain fatty acids that contributed to improving the memory and learning abilities following treatment with the probiotic mixture and suggested that probiotics could serve as a therapy to modulate physiological function.

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“…Moreover, decreases in cognitive function were demonstrated to severely impact the quality of life of patients ( 45 ). Although effective interventions to address these impairments and their underlying mechanisms remain to be identified ( 3 , 46 ), accumulating evidence has suggested that neuroinflammation in the brain may play a vital role in the pathophysiology of cognitive decline ( 47 ). To determine whether the anti-inflammatory properties of LBP exerted a protective effect against neurodegenerative disease, an OVX-induced cognitive impairment in vivo model was established, which is widely accepted as an experimental model for the study of neurodegenerative diseases ( 47 , 48 ).…”

Section: Discussionmentioning

confidence: 99%

“…Aging is a complex process characterized by a progressive loss of functions; in particular, learning and memory impairments (1). In women, decrease in estrogen levels is an important component of the aging following menopause, and brain and endocrine aging occur simultaneously and are closely associated with cognitive impairment and pathological states (2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of Lycium barbarum polysaccharide on ovariectomy‑induced cognition reduction in aging mice

Zheng

Wang

et al. 2021

Int J Mol Med

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Women experience cognitive decline as they age due to the decrease in estrogen levels following menopause. currently, effective pharmaceutical treatments for age-related cognitive decline are lacking; however, several Traditional chinese medicines have shown promising effects. Lycium barbarum polysaccharides (LBPs) were found to exert a wide variety of biological activities, including anti-inflammatory, antioxidant and anti-aging effects. However, to the best of our knowledge, the neuroprotective actions of LBP on cognitive impairment induced by decreased levels of estrogen have not yet been determined. To evaluate the effects of LBP on learning and memory impairment in an animal model of menopause, 45 female IcR mice were randomly divided into the following three groups: i) Sham; ii) ovariectomy (OVX); and iii) OVX + LBP treatment. The results of open-field and novel object recognition tests revealed that mice in the OVX group had learning and memory impairments, and lacked the ability to recognize and remember new objects. Notably, these deficits were attenuated following LBP treatment. Immunohistochemical staining confirmed the protective effects of LBP on hippocampal neurons following OVX. To further investigate the underlying mechanism of OVX in mice, mRNA sequencing of the hippocampal tissue was performed, which revealed that the Toll-like receptor 4 (TLR4) inflammatory signaling pathway was significantly upregulated in the OVX group. Moreover, reverse transcription-quantitative PcR and immunohistochemical staining demonstrated that OVX induced hippocampal injury, upregulated the expression levels of TLR4, myeloid differentiation factor 88 and NF-κB, and increased the expression of TNF-α, IL-6 and IL-1β inflammatory factors. conversely, LBP treatment downregulated the expression levels of mRNAs and proteins associated with the TLR4/NF-κB signaling pathway, decreased the inflammatory response and reduced neuronal injury in mice that underwent OVX. In conclusion, the findings of the present study indicated that oral LBP treatment may alleviate OVX-induced cognitive impairments by downregulating the expression levels of mRNAs and proteins associated with the TLR4/NF-κB signaling pathway, thereby reducing neuroinflammation and damage to the hippocampal neurons. Thus, LBP may represent a potential agent for the prevention of learning and memory impairments in patients with accelerated aging caused by estrogen deficiency.

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Oral administration of Grifola frondosa polysaccharides improves memory impairment in aged rats via antioxidant action

Abstract: These findings indicated that oral administration of GFP could improve memory impairment via antioxidant action, and dietary supplementation with GFP may provide potential benefits on brain aging.

Cited by 33 publications

References 40 publications

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Improving effect of a probiotic mixture on memory and learning abilities in d-galactose–treated aging mice

Protective effects of Lycium barbarum polysaccharide on ovariectomy‑induced cognition reduction in aging mice

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