Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity

Mutolo, Maria Giulia; Albanese, Giuseppe Maria; Rusciano, Dario; Pescosolido, Nicola

doi:10.1089/jop.2015.0121

Cited by 36 publications

(28 citation statements)

References 13 publications

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“…For instance, forskolin has been reported to act synergistically with homotaurine to protect RGC from death induced by increased IOP possibly by preventing calpain activation that is associated to neurodegenerative events [34]. In addition, in glaucoma patients with IOP compensated by topical drugs, food supplements containing forskolin, homotaurine, and group B vitamins have been found to increase both PERG amplitude and additional parameters related to RGC function [35]. Overall, literature data indicating the possible synergy between the different bioactive components of Gangliomix suggest that no single constituting element may have, per se, a neuroprotective activity comparable to that of the entire compound.…”

Section: Discussionmentioning

confidence: 99%

“…This amount of Gangliomix corresponds to 86.7 mg of a dry extract of spearmint (containing 20.9 mg of total polyphenols and 12.6 mg of rosmarinic acid) designated as Neumentix, 19.3 mg of dry extract of Coleus forskohlii (titrated at 10% in forskolin), 14.5 mg of homotaurine, 2.7 mg of vitamin PP, 0.4 mg of vitamin B2, 0.4 mg of vitamin B6, 0.3 mg of vitamin B1, and 0.5 mg of vitamin B12. Neumentix, which is rich in polyphenols and rosmarinic acid, is believed to be most beneficial for cognitive support by providing neurons with trophic supply [33] while the additional components of Gangliomix are also known to play a neuroprotective role [34,35].…”

Section: Dietary Supplementationmentioning

confidence: 99%

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Protective Efficacy of a Dietary Supplement Based on Forskolin, Homotaurine, Spearmint Extract, and Group B Vitamins in a Mouse Model of Optic Nerve Injury

et al. 2019

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Glaucoma is a multifactorial blinding disease with a major inflammatory component ultimately leading to apoptotic retinal ganglion cell (RGC) death. Pharmacological treatments lowering intraocular pressure can help slow or prevent vision loss although the damage caused by glaucoma cannot be reversed. Recently, nutritional approaches have been evaluated for their efficacy in preventing degenerative events in the retina although mechanisms underlying their effectiveness remain to be elucidated. Here, we evaluated the efficacy of a diet supplement consisting of forskolin, homotaurine, spearmint extract, and vitamins of the B group in counteracting retinal dysfunction in a mouse model of optic nerve crush (ONC) used as an in vivo model of glaucoma. After demonstrating that ONC did not affect retinal vasculature by fluorescein angiography, we determined the effect of the diet supplement on the photopic negative response (PhNR) whose amplitude is strictly related to RGC integrity and is therefore drastically reduced in concomitance with RGC death. We found that the diet supplementation prevents the reduction of PhNR amplitude (p < 0.001) and concomitantly counteracts RGC death, as in supplemented mice, RGC number assessed immunohistochemically is significantly higher than that in non-supplemented animals (p < 0.01). Major determinants of the protective efficacy of the compound are due to a reduction of ONC-associated cytokine secretion leading to decreased levels of apoptotic markers that in supplemented mice are significantly lower than in non-supplemented animals (p < 0.001), ultimately causing RGC survival and ameliorated visual dysfunction. Overall, our data suggest that the above association of compounds plays a neuroprotective role in this mouse model of glaucoma thus offering a new perspective in inflammation-associated neurodegenerative diseases of the inner retina.

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Section: Discussionmentioning

confidence: 99%

Section: Dietary Supplementationmentioning

confidence: 99%

Protective Efficacy of a Dietary Supplement Based on Forskolin, Homotaurine, Spearmint Extract, and Group B Vitamins in a Mouse Model of Optic Nerve Injury

et al. 2019

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“…Although more than one mechanism might account these synergistic properties, this neuroprotection was associated with reduced calpain activity, upregulation of the phosphoinositide 3-kinase (PI3K)/Akt pathway, and inhibition of glycogen synthase kinase-3 β (GSK-3 β ). Moreover, a recent pilot study demonstrated that oral administration of homotaurine, forskolin, carnosine, and folic acid improves intraocular pressure in patients with primary open-angle glaucoma [ 38 ]. Therefore, a multitarget approach by using a combination of molecules may be a more promising strategy to prevent retinal degeneration or slow down glaucomatous progression.…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells

Davinelli

Chiosi

Marco

et al. 2017

Oxidative Medicine and Cellular Longevity

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Citicoline and homotaurine are renowned compounds that exhibit potent neuroprotective activities through distinct molecular mechanisms. The present study was undertaken to demonstrate whether cotreatment with citicoline and homotaurine affects cell survival in primary retinal cultures under experimental conditions simulating retinal neurodegeneration. Primary cultures were obtained from the retina of fetal rats and exposed to citicoline plus homotaurine (100 μM). Subsequently, neurotoxicity was induced using excitotoxic levels of glutamate and high glucose concentrations. The effects on retinal cultures were assessed by cell viability and immunodetection of apoptotic oligonucleosomes. The results showed that a combination of citicoline and homotaurine synergistically decreases proapoptotic effects associated with glutamate- and high glucose-treated retinal cultures. This study provides an insight into the potential application of citicoline and homotaurine as a valuable tool to exert neuroprotective effects against retinal damage.

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“…e dosage change to a single tablet after 60 days showed a slight reduction in the effects on the advancement of the damage. e study performed by Mutolo et al [46] on the effects after administration of the same supplement showed significant results only after 6 months of therapy with 2 tablets a day.…”

Section: Journal Of Ophthalmologymentioning

confidence: 93%

Assessing the Performance of Daily Intake of a Homotaurine, Carnosine, Forskolin, Vitamin B2, Vitamin B6, and Magnesium Based Food Supplement for the Maintenance of Visual Function in Patients with Primary Open Angle Glaucoma

Rolle

Dallorto

Rossatto

et al. 2020

Journal of Ophthalmology

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Background. Glaucoma is a multifactorial optic neuropathy, which causes a continuous loss of retinal ganglion cells. Given the neurodegenerative nature of glaucoma, the necessity for neuroprotective intervention still arises, to be added alongside hypotonic therapy. Objective. The objective of this study was to assess the effect of daily intake of a homotaurine, carnosine, forskolin, vitamins B1, B2, and B6, folic acid, and magnesium based supplement (GANGLIOLIFE®) on the progression rates of the visual field in patients with progressive POAG despite good tonometric compensation and to assess the most suitable dosage. Methods. This is a monocentric nonrandomized experimental clinical study. Patients with mean deviation (MD) ranging from −2 dB to −15 dB with MD progression ≥1 dB in the previous year and IOP values of ≤18 mm Hg were included. All the patients underwent supplement therapy for a period of 6 months. For the first 2 months, they took 2 tablets a day, and for the following 4 months, 1 tablet a day. The patients were assessed before the start of treatment, time 0 (T0), after 2 months (T1), and after 6 months (T2) of therapy. At each check-up, patients were given a full eye test including perimetry, RNFL, and GCC using FD-OCT, PERG, contrast sensitivity, and QoL evaluation using the Glaucoma Symptom Scale questionnaire and National Eye Institute Visual Function Questionnaire 25. Results. 31 patients with a mean age of 70.80 ± 8.77 were included. At T1 and T2, the mean values of MD were lessened (MD = −5.37 ± −2.91, P<0.01, and MD = −5.48 ± 3.15, P<0.05, respectively) compared to T0 (MD = -5.98 ± 2.83). Patients also demonstrated a significant reduction in IOP (P<0.01), improved light sensitivity (P<0.01) and contrast sensitivity (P<0.05), and a better quality of life (P<0.05). Conclusions. Treatment with a supplement which includes homotaurine, carnosine, forskolin, vitamins B1, B2, and B6, folic acid, and magnesium has been shown to be able to slow down the rate of progression of functional damage and improve visual function after 2 and 6 months of daily intake. Quality of life showed significant improvement.

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Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity

Cited by 36 publications

References 13 publications

Protective Efficacy of a Dietary Supplement Based on Forskolin, Homotaurine, Spearmint Extract, and Group B Vitamins in a Mouse Model of Optic Nerve Injury

Protective Efficacy of a Dietary Supplement Based on Forskolin, Homotaurine, Spearmint Extract, and Group B Vitamins in a Mouse Model of Optic Nerve Injury

Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells

Assessing the Performance of Daily Intake of a Homotaurine, Carnosine, Forskolin, Vitamin B2, Vitamin B6, and Magnesium Based Food Supplement for the Maintenance of Visual Function in Patients with Primary Open Angle Glaucoma

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