Oral administration of Eucalyptus globulus extract reduces the alloxan-induced oxidative stress in rats

Soussi, Ahlem; Hamden, Khaled; Marouane, Wafa; Bezzine, Sofiane; Damak, Mohamed; Jean-Claude, Murat; Abdelfattah, El Feki

doi:10.1016/j.cbi.2009.06.006

Cited by 39 publications

(20 citation statements)

References 27 publications

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“…Nigella sativa inhibited the intestinal absorption of glucose, supporting its use as an antidiabetic compound. Other examples of plants with antidiabetic properties that were studied and confirmed by literature studies include the following: Eucalyptus globules (Ahlem et al, 2009), Phaseolus vulgaris L. (Ocho-Anin Atchibri et al, 2010), Marrubium vulgare (Elberry et al, 2011), Coriandrum sativum L. (Aissaoui et al, 2011), Swertia punicea (Tian et al, 2010), Viscum album (Ohran et al, 2005), Brassica juncea (Thirumalai et al, 2011), Salvia officinalis L. (Eidi et al, 2005), Ruta graveolens (Ahmed et al, 2010), Carissa carandas (Itankar et al, 2011), Pinus pinaster (Bedekar et al, 2010;El-Zein et al, 2011), Punica granatum (Bagri et al, 2009), and Piper retrofractum (Kim et al, 2011).…”

Section: A Plant Extracts With Antidiabetic Actionmentioning

confidence: 95%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

130

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Diabetes has become the most common metabolic disease worldwide. In particular, type 2 diabetes is the most commonly encountered type of diabetes, which is characterised by the inability of the organism to respond to normal levels of circulating insulin, also called insulin resistance. Current antidiabetic therapy is based on synthetic drugs that very often have side effects. For this reason, there is a continuous need to develop new and better pharmaceuticals as alternatives for the management and treatment of the disease. Natural hypoglycaemic compounds may be attractive alternatives to synthetic drugs or reinforcements to currently used treatments. Their huge advantage is that they can be ingested in everyday diet. Recently, more attention is being paid to the study of natural products as potential antidiabetics. This mini review of the current literature is structured into three main sections focused on: (a) plant extracts, (b) plant biomolecules, and (c) other natural molecules that have been used for their antidiabetic effects. Potential molecular mechanisms of action are also discussed.

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Section: A Plant Extracts With Antidiabetic Actionmentioning

confidence: 95%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

130

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“…have been used in folk medicine for the treatment of ailments such as colds, fever, toothache, diarrhea and snake bites. Uses of Eucalyptus leaf hot decoctions as "herbal tea" have been recorded in Aboriginal, European and British Pharmacopeias for the traditional remedy of type DM [10][11][12][13][14][15][16][17][18][19][20][21] . A rich literature exists, reporting over 500 Eucalyptus species with different pharmacological actions [11][12][13][14][15][16][17][18][19][20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

“…Uses of Eucalyptus leaf hot decoctions as "herbal tea" have been recorded in Aboriginal, European and British Pharmacopeias for the traditional remedy of type DM [10][11][12][13][14][15][16][17][18][19][20][21] . A rich literature exists, reporting over 500 Eucalyptus species with different pharmacological actions [11][12][13][14][15][16][17][18][19][20][21][22] . Hypoglycemic potentials of Eucalyptuses are documented, but the mechanistic actions need to be explored further [11][12][13][14][15][16][17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

“…A rich literature exists, reporting over 500 Eucalyptus species with different pharmacological actions [11][12][13][14][15][16][17][18][19][20][21][22] . Hypoglycemic potentials of Eucalyptuses are documented, but the mechanistic actions need to be explored further [11][12][13][14][15][16][17][18][19][20][21] . Inhibiting the actions of carbohydrate hydrolyzing enzymes like α-amylase and α-glucosidase helps to reduce post-prandial (PP) hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

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Exploration of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays

Dey¹,

Mitra²,

Katakam³

et al. 2014

WJD

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AIM:To investigate the presence and potency of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays. METHODS:The leaf extracts of the three different Eucalyptus species [E. globulus (EG), E. citriodora (EC), E. camaldulensis (ECA)] were subjected to in vitro assay procedures to explore the prevalence of natural enzyme inhibitors (NEIs) after preliminary qualitative and quantitative phytochemical evaluations, to study their inhibitory actions against the enzymes like α-amylase, α-glucosidase, aldose reductase, angiotensin converting enzyme and dipeptidyl peptidase 4 playing pathogenic roles in type 2 diabetes. The antioxidant potential and total antioxidant capacity of the species were also evaluated. RESULTS:Major bioactive compounds like polyphenols (341.75 ± 3.63 to 496.85 ± 3.98) and flavonoids (4.89 ± 0.01 to 7.15 ± 0.02) were found in appreciable quantity in three species. Based on the IC50 values of the extracts under investigation, in all assays the effectivity was in the order of EG > ECA > EC. The results of the ferric reducing antioxidant power assay showed that the reducing ability of the species was also in the order of EG > ECA > EC. A strong correlation (R 2 = 0.81-0.99) was found between the phenolic contents and the inhibitory potentials of the extracts against the targeted enzymes. CONCLUSION:

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“…Antihyperglycemic action not exerted via the stimulation of insulin secretion but via enhancement of peripheral glucose uptake, exerting an antioxidative activity demonstrated by the increase of catalase, superoxide-dismutase, and gluthatione-peroxidase activities in the liver and kidney, and a lowering of lipids peroxidation level in these organs [178]. Significantly improved the hyperglycemia, polydipsia, polyphagia, and also compensated weight loss of diabetic rats, in addition to treatment of candidiasis in normal and diabetic rats [179].…”

mentioning

confidence: 99%