Oral administration of chondroitin sulfate-functionalized nanoparticles for colonic macrophage-targeted drug delivery

Zhang, Xueqing; Ma, Yu; Ma, Lijun; Zu, Menghang; Song, Heliang; Xiao, Bo

doi:10.1016/j.carbpol.2019.115126

Cited by 64 publications

(31 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 290 Chondroitin sulphate functionalised nanoparticles have been used to target macrophages expressing CD44 to reduce the inflammation in Ulcerative Colitis, where CS-coated nanoparticles had better biological outcome both in vitro and in vivo versus non-coated counterparts. 291 Chitosan, on the other hand, is positively charged, an unconventional property for a polysaccharide, allowing its attachment to negatively charged surfaces through electrostatic interactions, such as mucosal membranes. Hence, it can play an essential role in oral, nasal, and ocular drug delivery.…”

Section: Targeted Drug Delivery Through Natural Biological Motifsmentioning

confidence: 99%

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Joyce

Fabra

Bozkurt

et al. 2021

Sig Transduct Target Ther

117

View full text Add to dashboard Cite

Biomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, and more. There is an increasing trend in tissue engineering to use natural substrates, such as macromolecules native to plants and animals to improve the biocompatibility and biodegradability of delivered materials. At the same time, these materials have favourable mechanical properties and often considered to be biologically inert. More importantly, these macromolecules possess innate functions and properties due to their unique chemical composition and structure, which increase their bioactivity and therapeutic potential in a wide range of applications. While much focus has been on integrating these materials into these devices via a spectrum of cross-linking mechanisms, little attention is drawn to residual bioactivity that is often hampered during isolation, purification, and production processes. Herein, we discuss methods of initial material characterisation to determine innate bioactivity, means of material processing including cross-linking, decellularisation, and purification techniques and finally, a biological assessment of retained bioactivity of a final product. This review aims to address considerations for biomaterials design from natural polymers, through the optimisation and preservation of bioactive components that maximise the inherent bioactive potency of the substrate to promote tissue regeneration.

show abstract

Section: Targeted Drug Delivery Through Natural Biological Motifsmentioning

confidence: 99%

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Joyce

Fabra

Bozkurt

et al. 2021

Sig Transduct Target Ther

117

View full text Add to dashboard Cite

show abstract

“…Two similar studies demonstrated the use of a chitosan and alginate hydrogel to encapsulate nanoparticles loaded with curcumin and 6-shogaol, a biologic compound found in ginger. The formulations significantly alleviated the colitis symptoms and quickened wound repair in mice ( Figure 4 ) [ 65 , 66 ]. Interesting use of other chitosan hydrogel was in the design of an antibody functionalized nanoparticles-releasing hydrogel.…”

Section: Marine-derived Bioactive Compounds Against Inflammatory Bowementioning

confidence: 99%

“…Two studies described the development of curcumin-loaded nanoparticles with their surfaces functionalized with CS. This modification yielded prominently targeted drug delivery to macrophages and was considered a promising therapeutic platform for IBD [ 65 , 126 ]. Additionally, a prospective, observational, follow-up study indicated that IBD patients in remission under CS treatment for osteoarthritis could have a lower incidence of relapses than generally reported in the literature.…”

Section: Marine-derived Bioactive Compounds Against Inflammatory Bowementioning

confidence: 99%

Exploitation of Marine-Derived Robust Biological Molecules to Manage Inflammatory Bowel Disease

et al. 2021

View full text Add to dashboard Cite

Naturally occurring biological entities with extractable and tunable structural and functional characteristics, along with therapeutic attributes, are of supreme interest for strengthening the twenty-first-century biomedical settings. Irrespective of ongoing technological and clinical advancement, traditional medicinal practices to address and manage inflammatory bowel disease (IBD) are inefficient and the effect of the administered therapeutic cues is limited. The reasonable immune response or invasion should also be circumvented for successful clinical translation of engineered cues as highly efficient and robust bioactive entities. In this context, research is underway worldwide, and researchers have redirected or regained their interests in valorizing the naturally occurring biological entities/resources, for example, algal biome so-called “treasure of untouched or underexploited sources”. Algal biome from the marine environment is an immense source of excellence that has also been demonstrated as a source of bioactive compounds with unique chemical, structural, and functional features. Moreover, the molecular modeling and synthesis of new drugs based on marine-derived therapeutic and biological cues can show greater efficacy and specificity for the therapeutics. Herein, an effort has been made to cover the existing literature gap on the exploitation of naturally occurring biological entities/resources to address and efficiently manage IBD. Following a brief background study, a focus was given to design characteristics, performance evaluation of engineered cues, and point-of-care IBD therapeutics of diverse bioactive compounds from the algal biome. Noteworthy potentialities of marine-derived biologically active compounds have also been spotlighted to underlying the impact role of bio-active elements with the related pathways. The current review is also focused on the applied standpoint and clinical translation of marine-derived bioactive compounds. Furthermore, a detailed overview of clinical applications and future perspectives are also given in this review.

show abstract

“…We previously demonstrated that chondroitin sulphate (CS), a family member of glycosaminoglycan that targets CD44 receptors, is overexpressed on tumour cells [23][24][25]. CS also target the Golgi apparatus after the cellular uptake process [26].…”

Section: Introductionmentioning

confidence: 99%

A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer

et al. 2021

View full text Add to dashboard Cite

Background Lung cancer is the most common type of tumour worldwide. Its relative lethality is considerably high. However, since the tumour tissues are located deep within the human body, traditional technologies, such as photodynamic therapy, do not have the desired effect. Sonosensitisers can penetrate deeply into tissues, and sonodynamic therapy (SDT) effectively inhibits tumours by generating reactive oxygen species. Ultrasound can also penetrate deeply, with a favourable tumour inhibition effect. Results A redox/ultrasound-responsive Rhein-chondroitin sulphate-based nano-preparation encapsulating docetaxel was fabricated. The nanoparticles displayed increased cellular uptake with quick drug release, good stability, and a monodispersed form in the physiological environment. Rhein induced apoptosis and altered mitochondrial membrane potential, which enhanced the expression of apoptosis-related proteins. SDT inhibited the metastasis and angiogenesis of cancer cells and activated anti-tumour capacity by reducing the expression of M2 macrophages. Conclusions The potential of Rhein for SDT was demonstrated. Production of reaction oxygen species was markedly enhanced after ultrasound treatment. The nanoplatform enhanced the synergistic anti-tumour effects of SDT and chemotherapeutic efficacy. The approach was biocompatibility. The findings could inform investigations of chemo-SDT for different cancers.

show abstract

Oral administration of chondroitin sulfate-functionalized nanoparticles for colonic macrophage-targeted drug delivery

Cited by 64 publications

References 33 publications

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Exploitation of Marine-Derived Robust Biological Molecules to Manage Inflammatory Bowel Disease

A sonosensitiser‐based polymeric nanoplatform for chemo‐sonodynamic combination therapy of lung cancer

Contact Info

Product

Resources

About