Oral administration of bovine lactoferrin inhibits bacterial infection in tilapia and elevates survival after bacterial infection: an examination of its immune-modulating properties

Wang, Yi-Da; Chang, Hsiao-Yun; Chen, Jyh-Yih; Chen, Jian-Chyi

doi:10.1007/s10499-012-9537-1

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…However, other measurements were not influenced by bLF treatment (Table 1). Another research group evaluated oral bLF administration in hybrid tilapia as a possible immunomodulator (Wang et al., 2013). In this case, the experimental challenge was with Streptococcus agalactiae .…”

Section: Features Of Blfmentioning

confidence: 99%

Bovine lactoferrin in fish culture: Current research and future directions

Luna-Castro

Ceballos-Olvera

Benavides-González

et al. 2021

Aquaculture Research

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Lactoferrin is a mammalian cationic iron‐binding glycoprotein of the innate immune system that belongs to the transferrin family of proteins. Present in colostrum, milk and tears, and exhibiting a wide range of biological properties in vitro and in vivo, lactoferrin is a nutraceutical component used as a food supplement for humans. Evidence from veterinary medicine and animal production suggests the potential use of lactoferrin as a microbicide, microbiostatic, microbiota modulator or immunostimulant. Bovine lactoferrin is the most common type of lactoferrin in animal production research, because it is more easily produced and sold all over the world. Administering bovine lactoferrin to dairy cattle, chickens and pigs causes several physiological changes that may affect immune system behaviour, microbiota status and iron homeostasis. This could increase resistance to pathogens and, in some cases, improve growth performance. The present review analyses the in vitro and in vivo effects of bovine lactoferrin on fish species for human consumption. Although there is no consensus on how bovine lactoferrin can modify the physiology of fish in vivo, the results of in vitro assays suggest a similar molecular mechanism to that previously described in mammals.

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Section: Features Of Blfmentioning

confidence: 99%

Bovine lactoferrin in fish culture: Current research and future directions

Luna-Castro

Ceballos-Olvera

Benavides-González

et al. 2021

Aquaculture Research

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show abstract

“…While it is known for a long time that dietary LF enhances the activity of the innate immune system in fish by increasing superoxide anion production by macrophages and haemolytic complement, lysozyme, phagocytic and bactericidal activities (Esteban et al 2005;Eslamloo et al 2012;Kakuta 1997Kakuta , 1998Rahimnejad et al 2012;Sakai et al 1993;Wang et al 2013;Yokoyama et al 2005), there is very little information regarding the use of exogenous LF as a modulator of acquired immunity.…”

Section: Introductionmentioning

confidence: 99%

Potential use of bovine lactoferrin as adjuvant for the modulation of the specific immune response in rainbow trout (Oncorhynchus mykiss W.)

Gualandi

Caputo

2016

Aquacult Int

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The present experiment was carried out in order to evaluate the potential\ud adjuvant effect of bovine lactoferrin (bLF) in modulating the specific antibody (Ab)\ud response to an exogenous protein, the human-c-globulins (HcG), injected intraperitoneally\ud in rainbow trout Oncorhynchus mykiss (Walbaum 1792). Moreover, serum natural antibody\ud (NatAb) level, serum total immunoglobulin (IgM) level and specific Ab response to\ud bLF were also analysed. Experimental data showed that HcG is able to stimulate a specific\ud Ab response when not adjuvanted with Freund’s complete adjuvant (FCA), whereas bLF\ud induces a specific Ab response only if adjuvanted with FCA. Statistical analyses revealed\ud that neither bLF or FCA administered singly had significant effects on serum NatAb and\ud IgM levels, whereas the specific immune response observed against HcG when adjuvanted\ud with bLF was comparable to that achieved when FCA was used as the adjuvant. These\ud results provide evidence of the potential for bLF to be used as an adjuvant for salmonids

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Therapeutic uses and applications of bovine lactoferrin in aquatic animal medicine: an overview

Abdelnour

Ghazanfar²,

Abdelhamid

et al. 2023

Vet Res Commun

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Aquaculture is an important food sector throughout the globe because of its importance in ensuring the availability of nutritious and safe food for human beings. In recent years, this sector has been challenged with several obstacles especially the emergence of infectious disease outbreaks. Various treatment and control aspects, including antibiotics, antiseptics, and other anti-microbial agents, have been used to treat farmed fish and shrimp against diseases. Nonetheless, these medications have been prohibited and banned in many countries because of the development of antimicrobial-resistant bacterial strains, the accumulation of residues in the flesh of farmed fish and shrimp, and their environmental threats to aquatic ecosystems. Therefore, scientists and researchers have concentrated their research on finding natural and safe products to control disease outbreaks. From these natural products, bovine lactoferrin can be utilized as a functional feed supplement. Bovine lactoferrin is a multi-functional glycoprotein applied in various industries, like food preservation, and numerous medications, due to its non-toxic and ecological features. Recent research has proposed multiple advantages and benefits of using bovine lactoferrin in aquaculture. Reports showed its potential ability to enhance growth, reduce mortalities, regulate iron metabolism, decrease disease outbreaks, stimulate the antioxidant defense system, and recuperate the overall health conditions of the treated fish and shrimp. Besides, bovine lactoferrin can be considered as a safe antibiotic alternative and a unique therapeutic agent to decrease the negative impacts of infectious diseases. These features can be attributed to its well-known antibacterial, anti-parasitic, anti-inflammatory, immunostimulatory, and antioxidant capabilities. This literature review will highlight the implications of bovine lactoferrin in aquaculture, particularly highlighting its therapeutic features and ability to promote immunological defensive pathways in fish. The information included in this article would be valuable for further research studies to improve aquaculture’s sustainability and the functionality of aquafeeds.

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Oral administration of bovine lactoferrin inhibits bacterial infection in tilapia and elevates survival after bacterial infection: an examination of its immune-modulating properties

Cited by 5 publications

References 48 publications

Bovine lactoferrin in fish culture: Current research and future directions

Bovine lactoferrin in fish culture: Current research and future directions

Potential use of bovine lactoferrin as adjuvant for the modulation of the specific immune response in rainbow trout (Oncorhynchus mykiss W.)

Therapeutic uses and applications of bovine lactoferrin in aquatic animal medicine: an overview

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