Oral administration of Bifidobacterium longum CECT 7347 modulates jejunal proteome in an in vivo gliadin-induced enteropathy animal model

Olivares, Marta; Laparra, Moisés; Sanz, Yolanda

doi:10.1016/j.jprot.2012.09.005

Cited by 27 publications

(21 citation statements)

References 39 publications

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“…With regard to the role of the microbiota in this process, exposure to specific bacterial strains in vivo does impact epithelial permeability and underlying mucosal immunity. For example, administration of the intestinal commensal Bifidobacterium longum to the induced rat model is protective to emergence of disease and associated with increased mucosal anti-inflammatory activity such as increased IL-10 88 89. However, this strategy has been directed at exploring the effect of targeted exposure of single agents, rather than an assessment of total microbiome composition dysbiosis in its entirety.…”

Section: Coeliac Diseasementioning

confidence: 99%

Does the microbiota play a role in the pathogenesis of autoimmune diseases?

McLean

Dieguez

Miller

et al. 2014

Gut

183

112

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The microbiota of the human metaorganism is not a mere bystander. These microbes have coevolved with us and are pivotal to normal development and homoeostasis. Dysbiosis of the GI microbiota is associated with many disease susceptibilities, including obesity, malignancy, liver disease and GI pathology such as IBD. It is clear that there is direct and indirect crosstalk between this microbial community and host immune response. However, the precise mechanism of this microbial influence in disease pathogenesis remains elusive and is now a major research focus. There is emerging literature on the role of the microbiota in the pathogenesis of autoimmune disease, with clear and increasing evidence that changes in the microbiota are associated with some of these diseases. Examples include type 1 diabetes, coeliac disease and rheumatoid arthritis, and these contribute significantly to global morbidity and mortality. Understanding the role of the microbiota in autoimmune diseases may offer novel insight into factors that initiate and drive disease progression, stratify patient risk for complications and ultimately deliver new therapeutic strategies. This review summarises the current status on the role of the microbiota in autoimmune diseases.

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Section: Coeliac Diseasementioning

confidence: 99%

Does the microbiota play a role in the pathogenesis of autoimmune diseases?

McLean

Dieguez

Miller

et al. 2014

Gut

183

112

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show abstract

“…This leads to shortening of villi, crypt hyperplasia, and increased numbers of intestinal CD8αβ+ IELs 46 . Recent papers that have utilized this model have evaluated the role of intestinal bacteria in the development of celiac disease 47, 48 . In Laparra et al, administration of Bifidobacterium longum was shown to protect against the effects of gliadin sensitization of the rats 47 .…”

Section: In Vivo Models Of Celiac Diseasementioning

confidence: 99%

“…Specifically, TNFα was significantly decreased, but IL10 was significantly increased in jejunal tissue sections, thereby significantly decreasing the inflammation induced by gliadin alone in the jejunum. Olivares et al used MALDITOF-TOF peptide fingerprinting analysis to confirm that feeding the rats B. longum results in the up-regulation of anti-inflammatory processes and that this is enough to partially ameliorate gliadin induced stress when both B. longum and gliadin are administered to the rats 48 . In a separate study, it was determined that co-administration of Shigella or E. coli with gliadin resulted in an increase in the impairment of tight junctions and resulted in translocation of gliadin peptides into the lamina propria 49 .…”

Section: In Vivo Models Of Celiac Diseasementioning

confidence: 99%

“…Probiotics have also been studied extensively in HLA transgenic mice and rats 47, 48, 64, 65 . All of these studies indicate that probiotic therapy can ameliorate the inflammation induced by gluten and be useful as a supportive therapy for the gluten free diet; however, probiotics will probably not rise to the level of a monotherapy and will need to be administered indefinitely.…”

Section: Testing Novel Therapiesmentioning

confidence: 99%

See 1 more Smart Citation

Latestin vitroandin vivomodels of celiac disease

Stoven

Murray

Marietta

2013

Expert Opinion on Drug Discovery

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Introduction Currently, the only treatment for celiac disease is a gluten free diet, and there is an increased desire for alternative therapies. In vitro and in vivo models of celiac disease have been generated in order to better understand the pathogenesis of celiac disease, and this review will discuss these models as well as the testing of alternative therapies using these models. Areas Covered The research discussed describes the different in vitro and in vivo models of celiac disease that currently exist and how they have contributed to our understanding of how gluten can stimulate both innate and adaptive immune responses in celiac patients. We also provide a summary on the alternative therapies that have been tested with these models and discuss whether subsequent clinical trials were done based on these tests done with these models of celiac disease. Expert Opinion Only a few of the alternative therapies that have been tested with animal models have gone on to clinical trials; however, those that did go on to clinical trial have provided promising results from a safety standpoint. Further trials are required to determine if some of these therapies may serve as an effective adjunct to a gluten free diet to alleviate the adverse affects associated with accidental gluten exposure. A “magic-bullet” approach may not be the answer to celiac disease, but possibly a future cocktail of these different therapeutics may allow celiac patients to consume an unrestricted diet.

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“…Un estudio reciente en el que se compara la AN-PEP con varios suplementos enzimáticos comercializados actualmente para ayudar a la digestión del gluten en pacientes celiacos, pone de manifiesto la alta efectividad in vitro de esta enzima (Janssen et al, 2015). (Medina et al, 2008;Cinova et al, 2011;Olivares et al, 2012;Laparra et al, 2013;Olivares et al, 2014 (Gottlieb et al, 2015).…”

Section: Reducción Del Gluten Ex Vivounclassified

Papel de la microbiota humana en el metabolismo del gluten = Role of Human Microbiota in gluten metabolism

Herrán¹

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Oral administration of Bifidobacterium longum CECT 7347 modulates jejunal proteome in an in vivo gliadin-induced enteropathy animal model

Cited by 27 publications

References 39 publications

Does the microbiota play a role in the pathogenesis of autoimmune diseases?

Does the microbiota play a role in the pathogenesis of autoimmune diseases?

Latestin vitroandin vivomodels of celiac disease

Papel de la microbiota humana en el metabolismo del gluten = Role of Human Microbiota in gluten metabolism

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