Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis

Ramírez-Tortosa, M. C.; Mesa, María Dolores; Aguilera, Concepción M.; Quiles, José L.; Baró, L; Ramírez-Tortosa, César L.; Martínez-Victoria, Emilio; Gil, Ángel

doi:10.1016/s0021-9150(99)00207-5

Cited by 243 publications

(142 citation statements)

References 25 publications

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“…Asai and Miyazawa (2001) also found that no difference in plasma total cholesterol was observed among the treatments. But triacylglycerol concentration in the plasma VLDL fraction of rats fed curcuminoid was lower than that of control diet (Babu and Srinivassan, 1997;Ramireze-Tortosa et al, 1999). Levels of serum GOT and GPT were not influenced by the dietary TP.…”

Section: Blood Profilesmentioning

confidence: 98%

Effects of Dietary Turmeric Powder on Laying Performance and Egg Qualities in Laying Hens

Park¹,

Kim²,

Kim³

et al. 2012

Korean Journal of Poultry Science

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This experiment was conducted to investigate the dietary effects of turmeric powder (TP) on laying performances, egg qualities and its transfer into eggs. A total of two hundred, 60-wk-old, Lohmann Brown layers were divided into 4 groups, placed in to 5 replicates per group (10 layers each) and fed each one of four diets containing 0% TP (control), 0.10, 0.25 or 0.50% TP, respectively, for 7 wks. Egg production in the all groups fed diets containing TP were significantly higher than that in control (P<0.05). No differences in feed intakes, egg and eggshell qualities were observed among the treatments, but Roche color fan number (yolk color) in group fed diet with 0.5% TP was significantly higher than in control (P<0.05). In the groups fed diets containing TP, Haugh units after 2 wk of storage were significantly higher than that of control (P<0.05). The curcumin content of egg yolk in the groups fed diet containing 0.50% TP was significantly higher than those in the other groups (P<0.05). The cholesterol levels of egg yolk were not influenced by dietary TP. It was concluded that dietary TP was effective in improving laying performance and internal egg qualities. TP can be also used as a feed additive for the production of value-enhanced eggs with increased yolk color and curcumin content.

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Section: Blood Profilesmentioning

confidence: 98%

Effects of Dietary Turmeric Powder on Laying Performance and Egg Qualities in Laying Hens

Park¹,

Kim²,

Kim³

et al. 2012

Korean Journal of Poultry Science

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“…Curcumin could modulate cholesterol levels in several experimental models of atherosclerosis (Soudamini et al, 1992;Ramirez-Tortosa et al, 1999). Aside from inhibition of lipid peroxidation, curcumin also decreased cholesterol levels in both the serum and brain tissue of mice (Soudamini et al, 1992).…”

Section: Cholesterol and Statinsmentioning

confidence: 99%

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

Meeteren¹,

Teunissen

Dijkstra

et al. 2005

Eur J Clin Nutr

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“…Curcumin) or 1.7-bis-(-4-hydroxy-3-methoxiphenyl)-1,6-heptadiene-2,5-dione) as well as hydroalcoholic extract of dry Curcuma rhizome posses potential anti-inflammatory, immunomodulating, tumoricidal, antiprotozoal, antioxidant and antiatherogenic properties. In vivo model studies carried out by RamirezTortosa and associate (Ramirez-Tortosa et al, 1999) demonstrated significant reduction of oxidation of serum LDL-cholesterol in a model of atherosclerotic rabbits after intake of 1.6 mg/kg curcumin extract in the diet. Additionally, in commensurate to this, administration of hydroalchoholic extract of curcuma to rabbits strongly decreased the plasma level of cholesterol and the susceptibility of LDL to oxidation (RamirezTortosa et al, 1999).…”

Section: Curcumin: a Potent Cytoprotectormentioning

confidence: 95%

Cardiovascular Disease Could Be Contained Based on Currently Available Data!

Ofodile

2006

Dose-Response

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ᮀ Largely due to better control of infectious diseases and significant advances in biomedical research, life expectancy worldwide has increased dramatically in the last three decades. However, as the average age of the population has risen, the incidence of chronic age-related diseases such as arthritis, Alzheimer's, Parkinson's, cardiovascular disease, cancer, osteoporosis, benign prostatic hyperplasia, and late-onset diabetes have increased and have become serious public health problem, as well. The etiology of these disorders is still incompletely understood, therefore, neither preventive strategies nor long-term effective treatment modalities are available for these disorders. In keeping with the aforementioned, the ultimate goal in cardiovascular research is to prevent the onset of cardiovascular episodes and thereby allow successful ageing without morbidity and cognitive decline. Herein, I argue that cardiovascular episodes could be contained with relatively simple approaches. Cardiovascular disorder is characterized by cellular and molecular changes that are commonplace in age-related diseases in other organ system, such alterations include increased level of oxidative stress, perturbed energy metabolism, and "horror autotoxicus" largely brought about by the perturbation of ubiquitin -proteasome system, and excessive oxidative stress damage to the cardiac muscle cells and tissues, and cross-reactions of specific antibodies against human heat shock protein 60 with that of mycobacterial heat shock protein 65." Horror autotoxicus", a Latin expression, is a term coined by Paul Ehrlich at the turn of the last century to describe autoimmunity to self, or the attack of "self" by immune system, which ultimately results to autoimmune condition. Based on the currently available data, the risk of cardiovascular episodes and several other age-related disorders, including cancer, Alzheimer's disease and diabetes, is known to be influenced by the nature and level of food intake. Now, a wealth of scientific data from studies of rodents and monkeys has documented the significant beneficial effects of calorie restriction (CR) or dietary restriction (DR), and multiple antioxidant agents in extending life span and reducing the incidence of progeroid-related diseases. Reduced levels of cellular oxidative stress, protection of genome from deleterious damage, detoxification of toxic molecules, and enhancement of energy homeostasis, contribute to the beneficial effects of dietary restriction and multiple antioxidant agents. Recent findings suggest that employment of DR and multiple antioxidant agents (including, catalase, gluthatione peroxidase, CuZn superoxide dismutase, and Mn superoxide dismutase = enzymes forming the primary defense against oxygen toxicity), and ozone therapy may mount an effective resistance to pathogenic factors relevant to the pathogenesis of cardiovascular episodes. Hence, while further studies will be needed to establish the extent to which CR and multiple antioxidant agents will reduce incidence of ca...

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Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis

Cited by 243 publications

References 25 publications

Effects of Dietary Turmeric Powder on Laying Performance and Egg Qualities in Laying Hens

Effects of Dietary Turmeric Powder on Laying Performance and Egg Qualities in Laying Hens

Antioxidants and polyunsaturated fatty acids in multiple sclerosis

Cardiovascular Disease Could Be Contained Based on Currently Available Data!

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