OPV cannot eradicate polio from India: Do we need any further evidence?

Immunogenicity, reactogenicity and safety of human rotavirus vaccine (RIX4414) in Indian infants

“…This compares favorably to other live-attenuated vaccines such as OPV and measles in a region where early administration of such vaccines have not had an optimal public health impact, when compared to elsewhere in the world. [19][20][21] In the developing world, it is often observed that a particular attack of gastroenteritis is caused by many pathogens including rotavirus. However, the global efficacy studies of RIX4414 have demonstrated a reduction of 40-75% in the rate of hospitalization due to gastroenteritis of all causes in vaccinated infants.…”

Inactivated Polio Vaccine: its proposed role in the final stages of polio eradication

“…OPV was, for decades, the antigen of choice in countries with suboptimal sanitation and a concomitant high prevalence of enterovirus infections in the gastro-intestinal tracts of infants and children. The skeptical view that OPV could not stop transmission in India [16] was disproven in 2011, when India saw her last case of wild poliovirus. The United States of America started with an IPV based regime in 1955, going over to OPV for general vaccination in 1961.…”

Polio eradication in India: Need for caution

“…Employing inactivated poliovirus vaccine (IPV) would be one such option. Many recent articles including recommendations of National Institute of Health, Bethesda, USA, meeting on polio eradication in September, 2007 have advocated introduction of IPV even before eradication in hotspot states of India 1,4,5 . The higher economic burden of employing IPV can also be resolved by proper planning and judicious use 5 .…”