Opuntia ficus-indica Extract and Isorhamnetin-3-O-Glucosyl-Rhamnoside Diminish Tumor Growth of Colon Cancer Cells Xenografted in Immune-Suppressed Mice through the Activation of Apoptosis Intrinsic Pathway

Antunes‐Ricardo, Marilena; Guardado‐Félix, Daniela; Rocha-Pizaña, María del Refugio; Garza-Martinez, Jose; Acevedo-Pacheco, Laura; Gutiérrez-Uribe, Janet A.; Villela-Castrejón, Javier; López-Pacheco, Felipe; Serna‐Saldívar, Sergio O.

doi:10.1007/s11130-021-00934-3

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…OFI extract and its isolated glycoside (isorhamnetin‐3‐O‐glucosyl‐rhamnoside) resulted in G0/G1 cell cycle arrest, ROS production, and increased apoptosis induction in‐vitro using colon cancer cells (HT‐29 RFP). In addition, they decreased the tumor growth rate, myeloperoxidase activity, and total cholesterol levels in xenografted‐immunosuppressed mice models (Antunes‐Ricardo et al, 2021). Indicaxanthin from OFI was reported to cause significant in‐vitro inhibition of human melanoma cell proliferation and in‐vivo impairment of tumor progression in mice models of cutaneous melanoma (Allegra et al, 2018).…”

Section: Biological Activitiesmentioning

confidence: 99%

An overview and update on the chemical composition and potential health benefits of Opuntia ficus‐indica (L.) Miller

Abbas

Ezzat

El-Hefnawy

et al. 2022

Journal of Food Biochemistry

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Opuntia ficus‐indica (OFI), widely recognized as prickly pear, is native to Mexico and it is distributed in many areas of the world because of its socioeconomic, agronomic, and ecological benefits, besides its large amounts of functional, nutraceutical, and biological activities. Various parts of this plant including the fruit pulp and peel, cladode, and seeds are scientifically proven to have therapeutic potentials and are safe for human use. The contents of phytochemical compounds in each part of the OFI are different. Each pharmacological activity depends on the phytochemical compounds, the components used, and the extraction type. In this review, we summarize the active constituents from different parts of OFI and their pharmacological effects including the antioxidant, wound healing, skin protective, hepatoprotective, anticancer, antidiabetic, antihypercholesterolemic, and anti‐obesity activities. Besides its effects on the bone health, cardiovascular system, kidneys, and gastrointestinal tract, its gastroprotective, anti‐ulcer, anti‐inflammatory, antiviral, neuroprotective, sedative, analgesic, anxiolytic and antimicrobial effects and effects on cognitive and memory function are also mentioned. Practical applications Over the past few decades, the health benefits of Opuntia ficus‐indica (OFI) have received much attention. All parts of the plant, including the fruit pulp and peel, cladode, and seeds have found use in the treatment of many diseases. The chemical composition of OFI provides both a high nutritional value and various health benefits. Therefore, the aim of this review is to present the up‐to‐date research carried out on OFI phytochemicals, showing the most important biological activities reported.

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Section: Biological Activitiesmentioning

confidence: 99%

An overview and update on the chemical composition and potential health benefits of Opuntia ficus‐indica (L.) Miller

Abbas

Ezzat

El-Hefnawy

et al. 2022

Journal of Food Biochemistry

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“…Thus, colonic fermentation may have direct implications for health-and well-being-related dietary polyphenols. 62 In fact, extracts rich in isorhamnetin glycosides from O. ficus-indica and the isolated isorhamnetin-3-O-glucosylrhamnoside have demonstrated direct cytotoxic activity against human colorectal cancer cell lines in vitro and in a xenograftedimmunosuppressed mouse model, 66,67 while oral supplementation of isorhamnetin aglycone to dextran sulfate sodiuminduced murine colitis model attenuated the inflammatory response associated with inflammatory bowel disease, 68 suggesting that isorhamnetin derivatives in colonic fermentates may prevent colon-related diseases, ameliorate gastrointestinal dysfunction, and promote gut health.…”

Section: Colonic Fermentation Of Cacti Phytochemicalsmentioning

confidence: 99%

Cactaceae plants as sources of active bioavailable phytochemicals

et al. 2022

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“…It is used for cough, indigestion, abdominal pain, bruises and swelling, cardiovascular diseases, and hemorrhage. Also, its use for the prevention or treatment of colon cancers has been previously reported [ 15 ]. However, further investigations are required to gain a better understanding of the possible antitumor properties of ISO, given that its direct cellular targets and biological impacts remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Isorhamnetin Regulates Programmed Death Ligand-1 Expression by Suppressing the EGFR–STAT3 Signaling Pathway in Canine Mammary Tumors

Mei,

Zhang,

Zhi

et al. 2024

IJMS

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Programmed death ligand-1 (PD-L1) is highly expressed in a variety of cancer cells and suggests a poorer prognosis for patients. The natural compound isorhamnetin (ISO) shows promise in treating cancers and causing damage to canine mammary tumor (CMT) cells. We investigated the mechanism of ISO in reducing PD-L1 expression in CMT cells. Clustered, regularly interspaced short palindromic repeat-associated protein 9 (CRISPR/Cas9) was used to mediate CD274 knockout in U27 cells. Then, monoclonal cells were screened and cultured. Nucleotide sequencing and expression of PD-L1 were detected. Additionally, we examined cell migration, invasion, and damage. Immunofluorescent staining of PD-L1 was examined in U27 cells. The signaling pathways were measured by Western blotting. Murine xenotransplantation models and murine immunocompetent allograft mammary tumor models were established to evaluate the effect of ISO therapy. Expression of Ki-67, caspase3, and PD-L1 were analyzed by immunohistochemistry. A pull-down assay was used to explore which proteins could bind to ISO. Canine EGFR protein was purified and used to detect whether it directly binds to ISO using a surface plasmon resonance assay. ISO inhibited the EGFR-STAT3-PD-L1 signaling pathway and blocked cancer growth, significantly increasing the survival rate of healthy cells. The cell membrane receptor EGFR was identified as a direct target of ISO. ISO could be exploited as an antineoplastic treatment of CMT by targeting EGFR to suppress PD-L1 expression.

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Opuntia ficus-indica Extract and Isorhamnetin-3-O-Glucosyl-Rhamnoside Diminish Tumor Growth of Colon Cancer Cells Xenografted in Immune-Suppressed Mice through the Activation of Apoptosis Intrinsic Pathway

Cited by 9 publications

References 36 publications

An overview and update on the chemical composition and potential health benefits of Opuntia ficus‐indica (L.) Miller

An overview and update on the chemical composition and potential health benefits of Opuntia ficus‐indica (L.) Miller

Cactaceae plants as sources of active bioavailable phytochemicals

Isorhamnetin Regulates Programmed Death Ligand-1 Expression by Suppressing the EGFR–STAT3 Signaling Pathway in Canine Mammary Tumors

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